Protein Alignment trx and Setd2

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: XP_036010808.1
• Gene: Setd2 / 235626
• MGIID: 1918177
• Length: 2551
• Species: Mus musculus
• Alignment Length: 3025
• Identity: 565/3025 - (18%)
• Similarity: 946/3025 - (31%)
• Gaps: 1010/3025 - (33%)

  Fly   255 KALFVATPATSTGLACALVSPGGS------SQGGTFPISAALLRARKNSNKKFKNLNLARGEVML 313
            |..|:..|... |:|.:...|.|:      .:.|...:|.:....:|....:|           |
Mouse    52 KTGFIKGPVFK-GVASSRFLPKGTKTKVNLEEQGRQKVSFSFSFTKKTLQNRF-----------L 104

  Fly   314 PSTSKLKQLNSPVVDNPSPSPPIASGSTPSVEGGIGVGGVVSPGEDAA-------LKRV------ 365
            .:.|..||.:||    .||:||:...|.|.|:  :..|......|:::       |.|:
Mouse   105 TALSNEKQSDSP----NSPAPPLQVDSNPKVK--MDAGDTFPATEESSPPKSRVELGRIHFKKHL 163

  Fly   366 --LTEMP----NEVARDPSPSSCTAAANGAASGKGSASNGPPAMASSGDGSSPKSGADTG----- 419
              :|..|    :..|..|.|.:....|..|.|...|..:.||........|||...|...
Mouse   164 LHVTSRPQLAASTTAASPLPPTTQLPAVLAESMIDSPPSSPPPPPPPPQASSPSPPAQISEPVAL 228

  Fly   420 ---PSTSSTTA--------------KQKKTVTFRNVLETSDDKSVVKRFYNPDIRIPIVSIMKKD 467
               |:|:..|:              |:....:...|||....:.:|..    .:....|..:|:.
Mouse   229 PQPPATALMTSPPGPLPGDVAVRAQKESPVKSGPEVLEVDTKQDIVSN----SLEEHTVQTLKEQ 289

  Fly   468 SLNRPLNYSRGGECIVRPSILSKILNKNSNIDKLNSLKFRSAGASSSSSNQESGSSSNVFGLSRA 532
            :                ..:|.|   ::|:|.|...:   |.|:..|.|::::.|..........
Mouse   290 A----------------DHLLQK---EDSHIGKEEEV---SDGSKISLSSKKASSKKKSSQFEGT 332

  Fly   533 F-GAPMDEDDEGGVTFRRNDSPEDQNNAEDDEMDDDDDDEEAEEDDENEDDNDEAVSEKSAETEK 596
            | |:..|||     :.|.:.|....:......:|.:.|.:::....::||....:.|    :||:
Mouse   333 FLGSESDED-----SVRTSSSQRSHDLKSSTSIDKERDFKKSSAPSKSEDLGKSSRS----KTER 388

  Fly   597 SAGADERDPDEKQLVMDSHFVLPK-RSTRSSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGT 660
                |:|.....:|..|:.:|..: ||.|..|  :...|...:.|..|.  ||...|:..:.:.:
Mouse   389 ----DDRYCSYSKLERDTRYVSSRCRSERDRR--RSRSRSRSDRASRTS--LSYSRSERSHYYDS 445

  Fly   661 ---------------------------SSSSAGSTASTFSASTNLKLGKETFFNFGTLKPNSSAA 698
                                       ||.|......|:...|:.       .::..|:.:||.:
Mouse   446 ERRYHRSSPYRERTRYSRPYTDNRARESSDSEDEYKKTYPRRTSA-------HSYRDLRTSSSYS 503

  Fly   699 ------------------GNFVLRQPRLQFQADNQQATFTAPKACPTSPSAIPKPANSLATSSFG 745
                              |.:.   .:|:.::.......|..:.|        .|.|.|.... |
Mouse   504 KFDRDCKTETSYLEMERRGKYT---SKLERESKRTSEHETIKRCC--------SPPNELGFRR-G 556

  Fly   746 SLASTNSSTVTPTPSACSICSAVVSSKEVTQARKYGVVACDVCRKFFSKMTKKSISANSSTANTS 810
            |..|.:.::.:...||.        ||.:::..|:....|  |.: .::..|:|.|.:..|. .|
Mouse   557 SSYSKHDNSTSRYKSAL--------SKSISKNDKFKNSFC--CTE-LNEENKQSHSFSLQTP-CS 609

  Fly   811 SGSQQYLQCKGNE----GSPCSIHSAKSQLKN---FKKFYKDRCTACWLKKCMISFQLPAAHRSR 868
            .||:.....|.:|    |||    :..:||.:   |||..:
Mouse   610 KGSELRTINKISEREKTGSP----TPSNQLNDSPTFKKLDE------------------------ 646

  Fly   869 LSAILPPGMRGEAAAREEKSAELLS-PTGSLR-FTSTA--SSSSPSVVASTSVKWKSSGDSTSAL 929
             |.:|.|...|.......|..||.. ....|| |.|..  .:.||...|..:....|..|:.| :
Mouse   647 -SPVLKPEFIGHDGRESIKELELSKVKNDQLRNFCSIELNVNGSPETEADVATFCTSKTDAIS-M 709

  Fly   930 TSIKPNPLAENNVTFGS--TPLLRPAILENPLFLKISNAADQ-----------KLAAAEAISPSL 981
            ||       :::|| ||  :||::..:|.:..|..:....::           ..:....:.|.|
Mouse   710 TS-------DDSVT-GSEVSPLIKACMLSSNGFQNVGRCRERDSDDTCRQHNTSKSPFREMEPLL 766

  Fly   982 TKKNSKQEKEKVKESEQSEKLLSPTQAGTKKSGAAEAQVEEVQPQKEEAPQTSTTTQPSASNGAS 1046
            :..:.|.....||..:..:.|:.  :...|:....:.:..::.....|.|: :...:|||...:|
Mouse   767 SPHHDKLMSLPVKTIDYPKTLIK--EPVDKRHSCCKTKDSDIYCSPNENPE-AENAEPSAMTISS 828

  Fly  1047 HGVPQAELAGETNATGDTLKRQRIDLKGPRVKH---VCRSASIVLGQPLATFGEDQQPEDAADMQ 1108
            |......|..:|..         .|.:.|..:|   .|......:|   :|........|.  :.
Mouse   829 HSFVNVHLESKTVI---------CDNREPTDRHSENTCDEYKQSIG---STSSASHNHFDG--LY 879

  Fly  1109 QEIAAPVPSAIMEPSPEKPTHIVTDENDNCASCKTSPVGDESKPSKSSGSAQAEVKKATALGKEG 1173
            :.|.:...|::..|    |:.|..:||       |||..| :..||.........:|.|.:|...
Mouse   880 EPIGSSGISSLQSP----PSGIRCEEN-------TSPTLD-AVESKKGIDFLKYARKETDVGSAL 932

  Fly  1174 TASAAGGSSAKVTTRNAAVASNLIVAASKKQRNGDIATSSSVTQSSNQTQGRKTKEHRQQRTLIS 1238
            ..|..|                    .|.:.|:.::.:..|:.::  |.:|......|:.|..|.
Mouse   933 PDSGKG--------------------FSWENRHNNVLSGQSLQEA--QEEGNSILHERRGRPEIP 975

  Fly  1239 IDFWEN--------------YDPAEVCQTGFGLIVTETVAQRALCFLCGSTGLDPLIFCACCCEP 1289
            :|..:.              ||.....:...|:..|         ..|.|:|..|.| .:...|.
Mouse   976 LDEEQRGHTHISDDSEVVFPYDLNLTMEDSDGITYT---------LKCDSSGNAPEI-VSTVHED 1030

  Fly  1290 Y--HQYCVQDEYNLKHGSFEDTTLMGSLLETTV----NAS-----TGPSSSLNQLTQRLNWLCPR 1343
            |  ......||.:.:....:|:::..:.|::.|    |::     |.|.||.:..:.:
Mouse  1031 YSGSSASSSDESDSEDTESDDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYK------- 1088

  Fly  1344 CTVCYTCNMSSGSKVKCQKCQKNYHST-CLGTSKRLL--GADRPLICVNCLKCKSCSTTKVSKFV 1405
               .|:.....|.:.:....::.|.|. |..|.|..|  |.:|        ..:||    .|:|.
Mouse  1089 ---HYSDRWEDGLETRRHAYEEEYESKGCSQTEKYFLHKGTER--------SAESC----YSQFG 1138

  Fly  1406 GNLPMCTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGL-----SDEQYNLL 1465
                        ||..|..|           |:           .|::.:|:     :|.:.:.|
Mouse  1139 ------------RKADNHLP-----------DI-----------AHAQSDGVDSTSQTDSRSDHL 1169

  Fly  1466 STLPESIEFICKKCARRNESSKIKAEEWRQAVM----EEFKASLYSVLKLLSKSRQACALLKLSP 1526
            ..|              |....::|:..|...:    ::|:       .|.:||||.   :..|.
Mouse  1170 GHL--------------NPEDTLRAKTSRPQELPVYSDDFE-------DLPNKSRQQ---MIFSN 1210

  Fly  1527 RKKLRCTCGASSNQGKLQPKALQFSSGSD----NGLGSDGESQNSDDVYEFKDQQQQQQQRNANM 1587
            |..       ||..||.:   |.|||..|    :||.|..|.:|..  ::|    .||::.....
Mouse  1211 RPD-------SSRLGKTE---LSFSSSCDISRMDGLHSSEELRNLG--WDF----SQQERPTTTY 1259

  Fly  1588 NKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSY-----------VSLAEFNYDMSQ-VIQQS 1640
            .:|......|...::...::.:.  .......||.|           ..||   ||..| .:..|
Mouse  1260 QQPDSSYGTCGTHKYQQSTEHYG--GTHNYWQGNGYWDPRSAGRPPGTGLA---YDRIQGQVPDS 1319

  Fly  1641 NCDELDIAYKELLSEQFPWFQNETKACTDALEEDMFESCSGGNYEDLQDTGGVSASVYNEHSTSQ 1705
            ..|:.:        |:..|         |......|.|.|...:...:|.|.|.|...:.:|...
Mouse  1320 LTDDRE--------EEEHW---------DQRSGSHFSSPSNKFFFHQKDKGSVQAPEISSNSIKD 1367

  Fly  1706 AESRSGVLDIPLEEVDDF-----------------------------GSCGIKMRLDTRMCLFCR 1741
            |        :.:.|..||                             |....:.::...|
Mouse  1368 A--------LVMNERKDFSKNFEKNDIKERGPPKKRRQELESDSESDGELQARKKVRVEM----- 1419

  Fly  1742 KSGEGLSGEEARLLYCGHDCWVHTNCAM--------WSA-----------EVFEE----IDGSLQ 1783
            :.||....:.:.|:        ..:|||        |..           ::.||    .:....
Mouse  1420 EQGESSVPQHSELM--------GPSCAMDDFRDPQRWKEFAKLGKMPCYFDLIEENVYLTERKKN 1476

  Fly  1784 NVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCAR---SIDCAFLTDKSMYC------- 1838
            ..|..:.| ...:||.........|  ..:|||    .|..   .|:|:.......||
Mouse  1477 KSHRDIKR-MQCECTPLSKDERAQG--EVACGE----DCLNRLLMIECSSRCPNGDYCSNRRFQR 1534

  Fly  1839 PAHA--------KNGNALK-ANGSPSVTYESNF--EVSRPVYVELDRK--RKKLIEPAR---VQF 1887
            ..||        |.|..|: |...||.|:...:  ||       ||.|  :.::.|.||   :.:
Mouse  1535 KQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEV-------LDHKEFKARVKEYARNKNIHY 1592

  Fly  1888 HIGSLEVRQLGAIVPRFSDSYEAVVPINFLCSRLYWSSKEP-WKIVEYTVRTTIQNSSSTLTALD 1951
            :..:|:..::          .:|....|  |||....|.|| .:..::||...::....|...:.
Mouse  1593 YFMALKNDEI----------IDATQKGN--CSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVP 1645

  Fly  1952 VGRNYTVDHT-NPNSKEVQ---LGMAQIARWHTSLARSEFLENGGTDWSGEFPNPNSCVPPDENT 2012
            .|...|.|:. ....||.|   .|.|....:.....|......||                  ..
Mouse  1646 SGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGG------------------KM 1692

  Fly  2013 EEEPQQQADLLPPELKDAIFEDLPHELLDGISMLDIFLYDDKTDLFAISEQSKDGTQAMTSNQAQ 2077
            ::|..::.|.:..|| :|:.|:     .:|:|        ||..:.::|       :.|...:..
Mouse  1693 KKERSRKKDSVDGEL-EALMEN-----GEGLS--------DKNQVLSLS-------RLMVRIETL 1736

  Fly  2078 NQNQQAGGANSVSICDEDTRNSNTSLGNGWPASNPVEDAMLSAARNSSQVQMLK--------TLA 2134
            .|..                                  ..|...:|:.....||        :|.
Mouse  1737 EQKL----------------------------------TCLKLIQNTHSQSCLKSFLERHGLSLL 1767

  Fly  2135 WPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSS---QQRNKKEMATVAGVSRRQSISETSVEGVA 2196
            |      ..||.....|:.::.|.|.:..||..   ..:|..|.:.|..:.:|.|.::|:|.
Mouse  1768 W------IWMAELGDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVP--- 1823

  Fly  2197 TTSGSVRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQV 2261
                                                           ::..|||
Mouse  1824 -----------------------------------------------QLSEGDG----------- 1830

  Fly  2262 KCDRCQCTYRNYDAFQRHLPSCSPTMS---SNETESDVSGQGMTNNATQISAESL----NELQKQ 2319
                    |.:.:..:.|.|..:|..|   |.|.::|...:.:......||..|:    :::..:
Mouse  1831 --------YSSENTSRAHTPLNTPDPSAKPSTEMDTDTPKKLIFRRLKIISENSMDSAVSDVTSE 1887

  Fly  2320 LLANAG--GLNYLQSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSL------------GSGFFLS 2370
            |....|  .|:.|::.|....            :.||..||.||.|            .|....|
Mouse  1888 LECKDGKEDLDQLETVTVEED------------EELQSQQLLPQQLCESKVESEATIEVSKLPTS 1940

  Fly  2371 QPNPATQANTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQPQLIAVS--------TNPDGT- 2426
            :|...|:....|..  ...|:.         |:|:.|   |:|.:...||        ..||.|
Mouse  1941 EPEADTETEPKDSN--GTKLEE---------TIAEET---PSQDEEEGVSDVESERSQEPPDKTV 1991

  Fly  2427 ----------------QQFIQIPQTMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPLKTVATK 2475
                            ::..:||:..|     |....|:.....|.......||...|.::....
Mouse  1992 DISDLATKLLDSWKDLKEVYRIPKKSQ-----TEKESTVAERGRDAAAFRDQTAPKTPNRSRERD 2051

  Fly  2476 AAQQAAVKQRQLKSGHQVKPIQAKLQPHPQQHQQQQQTQVQQPITVMGQNLLQPQ----LLFQSS 2536
            ..:|:..|:::.:.|....|..|..:...:...:......::.:.:..:|.|..:    |..|..
Mouse  2052 PDKQSQNKEKRKRRGSLSPPSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEV 2116

  Fly  2537 TQTQAPQIILPQAQPQNIISFVTGDGSQGQPLQYISI-------PTAGEYKP--QPQPTATPTFL 2592
            .|.:|.:   .|.|.||:        ....||.:.|:       |.|| |.|  ..|....|
Mouse  2117 AQREAQK---QQQQMQNL--------GMTSPLPFDSLGYNASHHPFAG-YPPGYPMQAYVDP--- 2166

  Fly  2593 TTAPGAGATYLQTDASGNLVLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQP 2657
             :.|.||.           ||..|||                  :..:..|            .|
Mouse  2167 -SNPNAGK-----------VLLPTPS------------------MDPVCSP------------AP 2189

  Fly  2658 GSNQQPLILGGTGGGSSGLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQN 2722
            ..:.|||:      |.|     |.|    ||..|....:..:..:..:||.|:|        :||
Mouse  2190 YDHAQPLV------GHS-----TES----LAAPPSVPVVPHVAASVEVSSSQYV--------AQN 2231

  Fly  2723 ASFSATTTQVFQASKIEPIVDLPAGYVVLN---NTGDASSAGTFLNAASVLQQQTQDDTTTQILQ 2784
            .|.      |.|.|.: |::.:.|...|..   |..:::.     .:.||.||.:...:.|.|.
Mouse  2232 ESV------VHQDSNV-PVMPVQAPGPVQGQNYNVWESNQ-----QSVSVQQQYSPAQSQTTIY- 2283

  Fly  2785 NANFQFQSVPTSSGASTSMDYTSPVMVTAKIPPVTQIKRTNAQAKAAGISGVGKVPPQPQVVNKV 2849
               :|.|:      .||....|||...|.  ||:.|   :.||.....|.|.......||.| .|
Mouse  2284 ---YQGQT------CSTVYSVTSPYSQTT--PPIVQ---SYAQPSLQYIQGQQIFTAHPQGV-VV 2333

  Fly  2850 LPTSIVT-----------QQSQVQVKNSNLKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNMI 2903
            .||:.||           |..::.|.|:.|                 ..||....||   ||.::
Mouse  2334 QPTAAVTSIVAPGQPQSLQPPEMVVTNNLL-----------------DLPPPSPPKP---KTIVL 2378

  Fly  2904 RPIHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQQP 2938
            .|..|     ....|..|:. ..|.:.:|.|...|
Mouse  2379 PPNWK-----TARDPEGKIY-YYHVITRQTQWDPP 2407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390	22/100 (22%)
		PRK13914	<1006..>1224	CDD:237555	39/220 (18%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	17/86 (20%)
		PHD	1346..1390	CDD:214584	10/46 (22%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	7/60 (12%)
		ePHD_KMT2A_like	1737..1841	CDD:277134	22/136 (16%)
		FYRN	1890..1937	CDD:461787	10/47 (21%)
		FYRC	3388..3476	CDD:197781
		SET_KMT2A_2B	3575..3726	CDD:380947
Setd2	XP_036010808.1	AWS	1483..1537	CDD:197795	12/60 (20%)
		SET_SETD2	1537..1678	CDD:380949	37/159 (23%)
		WW	2378..2407	CDD:459800	7/34 (21%)
		SRI	2454..2542	CDD:462404