DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and G2e3

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	NP_001161435.1	Gene:	G2e3 / 217558	MGIID:	2444298	Length:	739	Species:	Mus musculus

Alignment Length:	432	Identity:	102/432 - (23%)
Similarity:	164/432 - (37%)	Gaps:	108/432 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1737 CLFCRKSGE--GLSGEEARLLYCGHDCW---VHTNCAMWSAEVFE---EIDG----SLQNVHSAV 1789
            |:||||:.:  ...||:..     ::.|   ||..|.:.|:.:::   |.:|    .::::...|
Mouse    14 CVFCRKNDDCPNKYGEKKT-----YEKWNFSVHYYCLLMSSGIWQRGKEEEGVYGFLIEDIRKEV 73

  Fly  1790 ARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDCAF-LTDK-SMYC----PAHAKNGNAL 1848
            .|...:|||||...||::||.|.:|...||.||....:|.| .||. :.:|    |..|...|
Mouse    74 QRASKLKCTVCKKNGASIGCVVPTCKRSYHLPCGLQKECIFQFTDNFASFCWKHRPVQAITSN-- 136

  Fly  1849 KANGSPSVTYESNFEVSRPVYVELDRKRKKLIEPARVQFHIGSLEVRQLGAIVPRFSDSYEAVVP 1913
            |.:.|...|....|....|.|..|.....|     ...||...|:|:.:.|.|..|..:
Mouse   137 KYSSSLPCTICLEFVEPIPTYNILQSPCCK-----NAWFHRDCLQVQAINAGVFFFRCT------ 190

  Fly  1914 INFLCSRLYWSSKE-------------PWKIVEYTVRTTIQNSSSTLTALDVGRNYTV---DHTN 1962
               ||:......||             .|::.|...:..:|:..    ..|:.|.:..   |:..
Mouse   191 ---LCNNTDIFQKEMLRMGIHIPEKDASWELEENAYQELLQSHD----RCDIRRCHCKKGRDYNE 248

  Fly  1963 PNSK-EVQ-----------LGMAQIARWHTSLARSEFLENGGTDWSGEF------PNPNS----- 2004
            |||| ||:           |..:.:..|..:.   |.|:.....::.:|      |..||
Mouse   249 PNSKWEVKRCQSCGSSGTHLACSSLQSWEQNW---ECLDCRRITYTSDFQKAPKHPLANSTNVTV 310

  Fly  2005 --CVPPDENTEEEPQQQA-----DLLPPELKDAIFEDLPHELLDGISML-----DIFLYDDKTDL 2057
              |: .:|::.:.|:|..     :||  .||..|.......:....|.|     ..|..|..|.|
Mouse   311 TDCL-LEESSSKLPRQSTVAQHKELL--RLKQEIQLSTTACIFRRQSCLTQRQGSKFRRDISTIL 372

  Fly  2058 FAISEQSKDGTQAMTSNQA--------QNQNQQAGGANSVSI 2091
            ..:..|.|..|:.:..|:|        |.|:|:...:.|:.:
Mouse   373 IELGFQIKKKTKTLYINKANVWRSALEQFQSQKFNPSCSIDV 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134	37/121 (31%)
		FYRN	1891..1935	CDD:283589	11/56 (20%)
		FYRC	3388..3476	CDD:197781
		SET	3590..3710	CDD:214614
G2e3	NP_001161435.1	ePHD_PHF7_G2E3_like	14..127	CDD:277139	36/117 (31%)
		PHD_PHF7_G2E3_like	232..285	CDD:276971	13/55 (24%)
		HECTc	388..704	CDD:294058	6/27 (22%)
		HECTc	411..713	CDD:214523	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810