Protein Alignment trx and EZH1

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_001308008.1
• Gene: EZH1 / 2145
• HGNCID: 3526
• Length: 753
• Species: Homo sapiens
• Alignment Length: 926
• Identity: 171/926 - (18%)
• Similarity: 311/926 - (33%)
• Gaps: 256/926 - (27%)

  Fly  2820 QIKR--TNAQAKAAGISGVGKVPPQPQVVNKVLPTSIVTQQSQVQVKNSNLKQSQVKGKAASGTG 2882
            |:||  .|..|||..::...||..:.|::|:      ..::.:||...|   ...|.|.......
Human    34 QLKRLQANMGAKALYVANFAKVQEKTQILNE------EWKKLRVQPVQS---MKPVSGHPFLKKC 89

  Fly  2883 TTCGAPPSIASKPLQKKTNMIRPIHKLEVKPKVMKPTPKVQN---QNHSLLQQQQQQQPQLQQQ- 2943
            |.....|..||:.:     ::|.::.:.:.|.:...:|..||   ::.::|........:::::
Human    90 TIESIFPGFASQHM-----LMRSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEED 149

  Fly  2944 ---IPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQMIH-IPQQQQPLQQQQVQVQPSMPIITLAE 3004
               |..::.|...||...::.||...........:::. :.|.....::............:..:
Human   150 ETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEEGHNDTSDGKQDDSKED 214

  Fly  3005 APVVQSQFVMEPQALEQQELANRVQHFSTSSSSSSSNCSLPTN-VVNPMQQQAPSTTSSSTTRPT 3068
            .||.:.:   :..|:|..:.:::.| |......|:.....|.| |.:.|:::....|..|
Human   215 LPVTRKR---KRHAIEGNKKSSKKQ-FPNDMIFSAIASMFPENGVPDDMKERYRELTEMS----- 270

  Fly  3069 NRVLPMQQRQEPAPLSNEC-PVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVYEAELK 3132
                      :|..|..:| |.:..|.......:..:|...:....:|:
Human   271 ----------DPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCF---------------- 309

  Fly  3133 VSSVLESIVPDVTMDAILEEQPVTESIYTEGLYE-KNSPGESKTEQLLLQQQQREQL---NQQLV 3193
                        ..|..|.....|.::|.....| |..|....|:..||.:..:|..   |.:..
Human   310 ------------KYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSK 362

  Fly  3194 NNGYLLDKHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKI 3258
            .:|....:|                             .:.:::|::...|...|....|.
Human   363 CSGRRRRRH-----------------------------HIVSASCSNASASAVAETKEGDS---- 394

  Fly  3259 LDNLTNDDCADSIATA-----TTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAA 3318
             |..|.:|.|.|.:.|     |..:..||....|     |....|.|.|. |:.||.|:......
Human   395 -DRDTGNDWASSSSEANSRCQTPTKQKASPAPPQ-----LCVVEAPSEPV-EWTGAEESLFRVFH 452

  Fly  3319 ATYINEMAD-AHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQPIQEPK 3382
            .||.|.... |.:|..|..:...:..::              :|....:||.....|.|..:...
Human   453 GTYFNNFCSIARLLGTKTCKQVFQFAVK--------------ESLILKLPTDELMNPSQKKKRKH 503

  Fly  3383 KMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPL--PEGPLADMGGIQMIGL 3445
            ::...| ..:||.:     |.:|.|::              :...|.  |:.|
Human   504 RLWAAH-CRKIQLK-----KDNSSTQV--------------YNYQPCDHPDRP------------ 536

  Fly  3446 KTNALKYLIEQLPGVEKCSKYTP---------KYHKRNGNVSTAANGAHGGNLGGSSASAALSVS 3501
                             |....|         |:.:.|.:.
Human   537 -----------------CDSTCPCIMTQNFCEKFCQCNPDC------------------------ 560

  Fly  3502 GGDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPR 3566
                              :|.:...||:...|.             ::.|..:.|:..|.:|...
Human   561 ------------------QNRFPGCRCKTQCNT-------------KQCPCYLAVRECDPDLCLT 594

  Fly  3567 RGTGSNLP---MAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTD 3628
            .|...:..   ::.|..:::...|.::.:..|.:.|.|.:..:.::..|.:.||.||||.....|
Human   595 CGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEAD 659

  Fly  3629 KRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRI 3693
            :|.:.|| :.:..::|.::::.|||||.:||..||.||...||||:|||.:.|...|.|||.|.|
Human   660 RRGKVYD-KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAI 723

  Fly  3694 VQGEELTYDYKFPFED 3709
            ..||||.:||::...|
Human   724 QAGEELFFDYRYSQAD 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	13/98 (13%)
		SET_KMT2A_2B	3575..3726	CDD:380947	49/135 (36%)
EZH1	NP_001308008.1	EZH2_WD-Binding	45..74	CDD:463308	8/34 (24%)
		PRC2_HTH_1	165..268	CDD:436286	14/106 (13%)
		SANT	439..480	CDD:238096	10/40 (25%)
		preSET_CXC	566..597	CDD:408079	7/43 (16%)
		SET_EZH1	614..749	CDD:380994	48/127 (38%)