DRSC/TRiP Functional Genomics Resources

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Protein Alignment trx and Kmt2a

DIOPT Version :9

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:NP_001344478.1 Gene:Kmt2a / 214162 MGIID:96995 Length:3966 Species:Mus musculus


Alignment Length:4552 Identity:1028/4552 - (22%)
Similarity:1616/4552 - (35%) Gaps:1419/4552 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RSKFPGKPSKS-------------INRKRISVLQLEDDAANPAEPQQPAPESQQPSGSGSGSS-- 52
            |.:||.:|..:             ..|:|:..|.|              |...|..|.|.|:.  
Mouse     6 RWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLL--------------PPGPQAGGGGPGAPPS 56

  Fly    53 ----AAREKGNNCDNDEDDNAPGGASISGNTASSSAGSGNSGNGSSSGSSTGSGSSGSGSTNGGS 113
                ||...|::           ||.:.|..|::||.|  |.:.|||.||:.|.|||......|.
Mouse    57 PPAVAAAAAGSS-----------GAGVPGGAAAASAAS--SSSASSSSSSSSSASSGPALLRVGP 108

  Fly   114 VNGGTHHKSAA---NLDK-EAVTKDQNGDGDKTRGNVSSAPSGKLSAAASGKALSKSSRTFSAST 174
            ........|||   ||.: .||..:..|.|       .|....:.....|.:.:...|.|.|.|.
Mouse   109 GFDAALQVSAAIGTNLRRFRAVFGESGGGG-------GSGEDEQFLGFGSDEEVRVRSPTRSPSV 166

  Fly   175 SVTSSGRSSGSSPDGNSGASSDGASSGIS-------CGKSTAKSTE----ASSGKLAKTTGAGTC 228
                  ::|...|.|...:.||...:.:|       ..||..||.:    ..|..:.|..|....
Mouse   167 ------KASPRKPRGRPRSGSDRNPAILSDPSVFSPLNKSETKSADKIKKKDSKSIEKKRGRPPT 225

  Fly   229 SSAKSSKASSGTTSEATTSGLSGACLKALFVATPATSTGLACALVSPGGSSQGGTFPISAALLRA 293
            ......|.:.|......|.|.....||.: ..||:.....|..:..                |||
Mouse   226 FPGVKIKITHGKDIAELTQGSKEDSLKKV-KRTPSAMFQQATKIKK----------------LRA 273

  Fly   294 RKNS--NKKFK--NLNLARGEVML-------PSTSKLKQLNSPVVDNPSPSPPIASGSTPSVEGG 347
            .|.|  ..|||  .|.:.|..|.:       |||.::|                    |||    
Mouse   274 GKLSPLKSKFKTGKLQIGRKGVQIVRRRGRPPSTERIK--------------------TPS---- 314

  Fly   348 IGVGGVVSPGEDAALKRVLTEMPNEVARDPSPSSCTAAANGAASGKGSASNGPPAMASSGDGSSP 412
                |::...|        .|.|.:|.:|                    ..|.|.:.........
Mouse   315 ----GLLINSE--------LEKPQKVRKD--------------------KEGTPPLTKEDKTVVR 347

  Fly   413 KSGADTGP--------STSSTTAK----------QKKTVTFRNVLETSDDKSVVKRFYNPDIR-- 457
            :|.....|        .|.:|.||          |||.......|:....|:.||     :||  
Mouse   348 QSPRRIKPVRIIPSCKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVK-----NIRQF 407

  Fly   458 -IPIVSIMKKDSLNRPLNYSRGGECIVRPSILSKILNKNSNIDKLNSLKF--RSAGASSSSSNQE 519
             :|:||.:....:..|..:....:  ..|.:      |.:.::...:.:|  .|.|:|..||...
Mouse   408 IMPVVSAISSRIIKTPRRFIEDED--YDPPM------KIARLESTPNSRFSATSCGSSEKSSAAS 464

  Fly   520 SGSSSNVFGLSRAFGAPMDEDDEGGVTFRRNDSPEDQNNAED--------DEMDDDDDDEEAEED 576
            ..||......||:....:|...:...:......||:::|..:        ...:::.:|..:...
Mouse   465 QHSSQMSSDSSRSSSPSIDTTSDSQASEEIQALPEERSNTPEVHTPLPISQSPENESNDRRSRRY 529

  Fly   577 DENEDDNDEAVSEK-----SAETEK------------------SAGADERDP--DEKQLVMDSHF 616
            ..:|.......::|     ||..::                  ::|..:..|  ....:.:.|.|
Mouse   530 SMSERSFGSRATKKLPTLQSAPQQQTSSSPPPPLLTPPPPLQPASGISDHTPWLMPPTIPLASPF 594

  Fly   617 V----LPKRSTRSSRIIKP------------------NKRLLEEGAISTKKPL------------ 647
            :    .|.:..|.|.:.:|                  :.:..:||.|  :||:            
Mouse   595 LPASAAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLI--RKPIFDNFRPPPLTPE 657

  Fly   648 SLGDSKGKNVFGTSSSS-------AGSTASTFSASTNLKLGKET-------FFNFGTLKPN---S 695
            .:|.:.|.:..||::|:       :|:.......|..|:..:.|       .|...||..|   |
Mouse   658 DVGFASGFSASGTAASARLFSPLHSGTRFDIHKRSPILRAPRFTPSEAHSRIFESVTLPSNRTSS 722

  Fly   696 SAAGNFVLRQPRLQFQADNQQATFTAPKACPTSPSAIPKPANSLATSSFGSLASTNSSTVTPTPS 760
            .|:.:.|..:.|       ::..|:..::.|.|||      :|:.|.| |.|:::..|.:||..|
Mouse   723 GASSSGVSNRKR-------KRKVFSPIRSEPRSPS------HSMRTRS-GRLSTSELSPLTPPSS 773

  Fly   761 ACSICSAVVS--------------SKEVTQARKYGVVACDVCRKFFSKMTKKSISANSSTANTSS 811
            ..|..|..||              |..:||:               .:.|:|:..|...|:..:.
Mouse   774 VSSSLSIPVSPLAASALNPTFTFPSHSLTQS---------------GESTEKNQRARKQTSALAE 823

  Fly   812 ---------------GSQQYLQCKGNEGSPCSIHSAKSQLKNFKKFYKDRCTACWLKKCMISFQL 861
                           |||..   ||.:........:|.:..: |...||:               
Mouse   824 PFSSNSPALFPWFTPGSQTE---KGRKKDTAPEELSKDRDAD-KSVEKDK--------------- 869

  Fly   862 PAAHRSRLSAILPPGMRGEAAAREEK--------SAELLSPTGSLRFTSTAS---SSSPSVVAST 915
             :..|.|     ......:..:|:||        |:..|.|.|.:.....|.   .:|.|...:|
Mouse   870 -SRERDR-----EREKENKRESRKEKRKKGSDIQSSSALYPVGRVSKEKVAGEDVGTSSSAKKAT 928

  Fly   916 SVKWKSSGDSTSALTSIKPNPLAENNVTFGSTPLLRPAILENPLFLK--ISNAADQKLAAAEAIS 978
            ..|..||.||.:   .:.|       ||.|.|..::..||     :|  ..|.....|....| :
Mouse   929 GRKKSSSLDSGA---DVAP-------VTLGDTTAVKAKIL-----IKKGRGNLEKNNLDLGPA-A 977

  Fly   979 PSLTKKN----SKQEKEKVKES--------EQSEKLLSPTQAGTKKSGAAEAQVEEVQPQKEEAP 1031
            |||.|:.    |......||.|        .|::||....:........|:||:.::    |::.
Mouse   978 PSLEKERTPCLSAPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKI----EKSK 1038

  Fly  1032 QTSTTTQPSASNGASHGVPQAELAGETNATGDTLKRQRIDLKGPRVKHVCRSASIVLGQPLATFG 1096
            ....|.||.|.             |:.:.:.:|      .::|||:|||||.|::.||:..|.|.
Mouse  1039 SLKQTDQPKAQ-------------GQESDSSET------SVRGPRIKHVCRRAAVALGRKRAVFP 1084

  Fly  1097 EDQQ---------------------------PEDAADMQQEIAAPVPSAIMEPSPEKPTHIVTDE 1134
            :|..                           .|||..:...| .|:.......:|::|.......
Mouse  1085 DDMPTLSALPWEEREKILSSMGNDDKSSVAGSEDAEPLAPPI-KPIKPVTRNKAPQEPPVKKGRR 1148

  Fly  1135 NDNCASCKTSPVGDE------------------------------------------------SK 1151
            :..|..|....|.::                                                .|
Mouse  1149 SRRCGQCPGCQVPEDCGICTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKASLQKQTKAVKKK 1213

  Fly  1152 PSKSSGSAQAEVKKATAL------------------------------------GKEGTASA--- 1177
            ..||..:.:.|.|::||:                                    .:||.|.|   
Mouse  1214 EKKSKTTEKKESKESTAVKSPLEPAQKAAPPPREEPAPKKSSSEPPPRKPVEEKSEEGGAPAPAP 1278

  Fly  1178 ----------AGGSSAKVTTRNAAV--------------ASNLIVAASK---------------- 1202
                      |...|:|..::.|||              |...:.:..|                
Mouse  1279 APEPKQVSAPASRKSSKQVSQPAAVVPPQPPSTAPQKKEAPKAVPSEPKKKQPPPPEPGPEQSKQ 1343

  Fly  1203 -----------KQRNGDIATSSSVTQSSNQ---------TQGRKTKE-------HRQQRTLISID 1240
                       ||:..|......|::..|.         :.|..:|:       ||     |.:|
Mouse  1344 KKVAPRPSIPVKQKPKDKEKPPPVSKQENAGTLNILNPLSNGISSKQKIPADGVHR-----IRVD 1403

  Fly  1241 FWENYDPAEVCQT-GFGLIVTETVAQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHG 1304
            |.|:.:...|.:. |.|::.:..:..|.:||||.|:|....::|..||||:|::|:::    ...
Mouse  1404 FKEDCEAENVWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEE----NER 1464

  Fly  1305 SFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTC---NMSSGSKVKCQKCQKN 1366
            ..||                          |..||.|.||..|:.|   :.::...::|.||:.:
Mouse  1465 PLED--------------------------QLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNS 1503

  Fly  1367 YHSTCLG-------TSKRLLGADRPLICVNCLKCKSCSTTKVSK-----FVGNLPMCTGCFKLRK 1419
            ||..|||       |.|:     :..||..|::||||.:|...|     :..:..:|..|.||..
Mouse  1504 YHPECLGPNYPTKPTKKK-----KVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFA 1563

  Fly  1420 KGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGLS---DEQYNLLSTLPESIEFICKKCAR 1481
            ||||||:|.:||||:|::.|||:||.|.:|||||||.||   ||.|.:||.||||:.:.|..|..
Mouse  1564 KGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCESLSGTEDEMYEILSNLPESVAYTCVNCTE 1628

  Fly  1482 RNESSKIKAEEWRQAVMEEFKASLYSVLKLLSKSRQACALLKLSPRKKLRCTCGASSNQGKLQPK 1546
            |:.:      |||.|:.:|.:|||..||..|..||....||:.....|          ...|.|:
Mouse  1629 RHPA------EWRLALEKELQASLKQVLTALLNSRTTSHLLRYRQAAK----------PPDLNPE 1677

  Fly  1547 ALQFSSGSDNGLGSDGESQNSDDVYEFKDQQQQQQQRNANMNKPRVKSLPCSCQQHISHSQSFSL 1611
                   ::..:.|....:..|.....:..:|.:|                         |...|
Mouse  1678 -------TEESIPSRSSPEGPDPPVLTEVSKQDEQ-------------------------QPLDL 1710

  Fly  1612 VDIKQKIAGNSYVSLAEFNYDMSQVIQ--------QSNCDELDIAYKELLSEQ----FPWFQ--- 1661
            ..:|:::...||||:.||:.|:.::||        |....:.:...|.....|    ||||.   
Mouse  1711 EGVKKRMDQGSYVSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKK 1775

  Fly  1662 ------NETKACTDALEEDMFESCSGGNYEDLQDTGGVSASVYNEH------------------- 1701
                  |:....:..|...:.......||...|:.   ..|.:.|.                   
Mouse  1776 SRFWEPNKVSNNSGMLPNAVLPPSLDHNYAQWQER---EESSHTEQPPLMKKIIPAPKPKGPGEP 1837

  Fly  1702 --------------STSQAESRSGVLDIPLEEVDDFGSCGIKMRLDTRMCLFCRKSGEGLSGEEA 1752
                          ||.::...|..|:.|         .||.   |.|.|..|...|:..:.:..
Mouse  1838 DSPTPLHPPTPPILSTDRSREDSPELNPP---------PGID---DNRQCALCLMYGDDSANDAG 1890

  Fly  1753 RLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEH 1817
            ||||.|.:.|.|.|||:|||||||:.||||:|||.||.||:.::|..|...||||||.:.||..:
Mouse  1891 RLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSN 1955

  Fly  1818 YHYPCARSIDCAFLTDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVE---LDRKRKKL 1879
            ||:.|:|:.:|.||.||.:||..|.   :.:|....|    |:.|||.|.|:|:   :..:||.|
Mouse  1956 YHFMCSRAKNCVFLDDKKVYCQRHR---DLIKGEVVP----ENGFEVFRRVFVDFEGISLRRKFL 2013

  Fly  1880 --IEPARVQFHIGSLEVRQLGAIVPRFSDSYEAVVPINFLCSRLYWSSKEPWKIVEYTVRTTIQN 1942
              :||..:...|||:.:..|| |:...||..:.:.||.:.|||:|||:.:..|...||.:  |..
Mouse  2014 NGLEPENIHMMIGSMTIDCLG-ILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCK--IME 2075

  Fly  1943 SSSTLTALDVGRNYTVDHTNPNSKEVQLGMAQIARWHTSLARSEFLENGGTDWSGEFPNPNSCVP 2007
            ....:...|:  |.||:|.:                :.::|.|                |:|.: 
Mouse  2076 CRPPVVEPDI--NSTVEHDD----------------NRTIAHS----------------PSSFI- 2105

  Fly  2008 PDENTEEEPQQQADLLPPELKDAIFEDLPHELLDG------ISMLDIFLYDDKTDLFAISEQS-- 2064
             |.:.::.....|.|.||.      .|.||....|      ||.:...    :|..::.:::|  
Mouse  2106 -DASCKDSQSTAAILSPPS------PDRPHSQTSGSCYYHVISKVPRI----RTPSYSPTQRSPG 2159

  Fly  2065 -----KDGTQAMTSNQAQNQNQQ--AGGANSVSICDEDTRNSNTSLG---NGWPASNPVEDAMLS 2119
                 ..|:...|:::.......  :.|..|:.    ..|:|.:||.   :.....:||......
Mouse  2160 CRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIG----SRRHSTSSLSPLRSKLRIMSPVRTGSAY 2220

  Fly  2120 AARNSSQVQMLKTLAWPKLDGNSAMATAIKRRKL---SKNLAEGVFLTLSSQQRNKKEMATVAGV 2181
            :..:.|.|..|.|...|:     |.|.|..|..|   |.||......:.|||:       ||.| 
Mouse  2221 SRSSVSSVPSLGTATDPE-----ASAKASDRGGLLSSSANLGHSAPPSSSSQR-------TVGG- 2272

  Fly  2182 SRRQSISETSVEGVATTSGS--------VRSKSFTWSAAKRYFEKSEG-REEAAKMRIMQMDGVD 2237
            |:...:..:|...|...|.|        |:.:....|::|    .::| ....|...|.::....
Mouse  2273 SKTSHLDGSSPSEVKRCSASDLVPKGSLVKGEKNRTSSSK----STDGSAHSTAYPGIPKLTPQV 2333

  Fly  2238 DSITEFRI-ISGDGNL---STAQFSGQ--VKCDRCQCTYRNYDAFQRHLPSCSPTMSSNETESDV 2296
            .:.|...: ||..|:.   ||..||.:  |...:.....:..|..|...||.|...|.|| :.::
Mouse  2334 HNATPGELNISKIGSFAEPSTVPFSSKDTVSYPQLHLRGQRSDRDQHMDPSQSVKPSPNE-DGEI 2397

  Fly  2297 SG---QGMTNNAT----QISAESLNELQKQLLANAGGLNYLQSATSFPQVQSLGSLGQF--GLQG 2352
            ..   .||.:..:    .|.:.|.:..||...::........|:.|:.:.      ||.  |.:|
Mouse  2398 KTLKLPGMGHRPSILHEHIGSSSRDRRQKGKKSSKETCKEKHSSKSYLEP------GQVTTGEEG 2456

  Fly  2353 LQQLQLQPQSLGSGFFLSQPNPATQANTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQPQLI 2417
            ..:.:...:.|..||...:|              .|::.|        ..:....:.....|:  
Mouse  2457 NLKPEFADEVLTPGFLGQRP--------------CNNVSS--------EKIGDKVLPLSGVPK-- 2497

  Fly  2418 AVSTNPDGTQQFIQIPQTMQATTTPTATYQTLQATNTDKKI-------------MLPLTAAGKPL 2469
            ..||..:|:.:.:|.|:......||.......|:.||.|:.             ..|::|:..|.
Mouse  2498 GQSTQVEGSSKELQAPRKCSVKVTPLKMEGENQSKNTQKESGPGSPAHIESVCPAEPVSASRSPG 2562

  Fly  2470 KTVATKAAQQAAVKQRQLKSGHQVKPIQAKL-----QPHPQQH---------------------- 2507
            .....:.:....:.|....:.:|..|.|.:.     .|.||:.                      
Mouse  2563 AGPGVQPSPNNTLSQDPQSNNYQNLPEQDRNLMIPDGPKPQEDGSFKRRYPRRSARARSNMFFGL 2627

  Fly  2508 --------------------------QQQQQTQV--------------------QQPITVMGQNL 2526
                                      ::..:.||                    :..|:..|:..
Mouse  2628 TPLYGVRSYGEEDIPFYSNSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEER 2692

  Fly  2527 LQPQLLFQSSTQTQAPQI---------------ILPQAQPQNIISFVTGDGSQGQPLQYISIPTA 2576
            |....||:...|...|:|               :...::..:.|....|..:..:.|:......|
Mouse  2693 LASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATSRKSSQIPKRNGKENGTENLKIDRPEDA 2757

  Fly  2577 GE----------YKPQPQ-PTATPTFLTTAPGAGATYLQTDA--SGNLVLTTTPSNSGL------ 2622
            ||          :|.:|: ..........|.|..:...|..:  |...|.|:|||:..|      
Mouse  2758 GEKEHVIKSAVGHKNEPKLDNCHSVSRVKAQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNA 2822

  Fly  2623 QMLTAQSLQAQPQVIGTLIQPQTIQL------GGGADGNQPGSNQQPLILGGTGGG-------SS 2674
            ::|.:.|........|.::....:..      ...|.|..|.|:...|:..|.|.|       ..
Mouse  2823 ELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLTLGEGLGLDSNREKDI 2887

  Fly  2675 GLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQF------------VSTAMPGMLSQNASFSA 2727
            || |...|.| :.||:|    :::.|.:::.:.:||            ::|..|.:.|||.|..|
Mouse  2888 GL-FEVFSQQ-LPATEP----VDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLA 2946

  Fly  2728 ----------TTTQVFQASK------IEPIVD-LPAGYVVLNNTGDASSAGTFLNAASVLQQQTQ 2775
                      |.|:...||.      :.|.|| .|.|::..::..........:::......:..
Mouse  2947 VISDSGEKRVTITEKSVASSEGDPALLSPGVDPAPEGHMTPDHFIQGHMDADHISSPPCGSVEQG 3011

  Fly  2776 DDTTTQILQNANFQFQSVPTSSGASTSMDYTSPVMVTAKIPPVTQIKRTNAQAKAAGISGVGKVP 2840
            ...:..:.:|:......||.|.        |.||.....:|..|.....:..:.||    |...|
Mouse  3012 HGNSQDLTRNSGTPGLQVPVSP--------TVPVQNQKYVPSSTDSPGPSQISNAA----VQTTP 3064

  Fly  2841 P----------------QPQVVNKVLPTSIVTQQSQV--------QVKNSNLKQSQVKGKAASG- 2880
            |                ||..|.:.||.. |||:.|:        .|..:|   :.|.|...|| 
Mouse  3065 PHLKPATEKLIVVNQNMQPLYVLQTLPNG-VTQKIQLTSPVSSTPSVMETN---TSVLGPMGSGL 3125

  Fly  2881 ---TGTTCGAPPSIASKPLQKKTNMIRPIHK-LEVKPKVMKPT--PKVQNQNHSLLQQQQQQQPQ 2939
               ||.....|||.:..|...|..:..|.|: |...|...:.:  |.:.:....||   ...||.
Mouse  3126 TLTTGLNPSLPPSPSLFPPASKGLLSVPHHQHLHSFPAAAQSSFPPNISSPPSGLL---IGVQPP 3187

  Fly  2940 LQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAE 3004
            ...|:.....||...:|.:   :...:...:.:....:|        .::..::.||.....:|.
Mouse  3188 PDPQLLGSEANQRTDLTTT---VATPSSGLKKRPISRLH--------TRKNKKLAPSSAPSNIAP 3241

  Fly  3005 APVVQSQFVMEPQALEQQELANRVQHFSTSSSSSSSNCSLPTNVVNPMQ------QQAP------ 3057
            :.||.:..::.   ....:|:|........|.:.||:.::| |::...:      :|||      
Mouse  3242 SDVVSNMTLIN---FTPSQLSNHPSLLDLGSLNPSSHRTVP-NIIKRSKSGIMYFEQAPLLPPQS 3302

  Fly  3058 -----------STTSSSTTRPTN-------------RVLPMQQRQEP---------APLSNE--- 3086
                       ||.|..|:..|:             .|:.||....|         ..|:|:   
Mouse  3303 VGGTAATAAGSSTISQDTSHLTSGPVSALASGSSVLNVVSMQTTAAPTSSTSVPGHVTLANQRLL 3367

  Fly  3087 -CPVVSSPTPPKPVEQPIIHQMTSAS---------------VSKCYAQKSTLPSPVYEAELKVSS 3135
             .|.:.|          |.|.:..||               .|..:.|..|..:|...|....||
Mouse  3368 GTPDIGS----------ISHLLIKASHQSLGIQDQPVALPPSSGMFPQLGTSQTPSAAAMTAASS 3422

  Fly  3136 VLESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLD 3200
            :.                 |..|..|.|:...:.|||:: |...||:.     ||.|..      
Mouse  3423 IC-----------------VLPSSQTAGMTAASPPGEAE-EHYKLQRG-----NQLLAG------ 3458

  Fly  3201 KHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKILDNLTND 3265
                          :...|..:.|.|.|.:  ..|...|..:.:::.. .|:.:.:|.|.:.   
Mouse  3459 --------------KTGTLTSQRDRDPDSA--PGTQPSNFTQTAEAPN-GVRLEQNKTLPSA--- 3503

  Fly  3266 DCADSIATATTMEVDASAGYQQMVEDVLATTAAQ------SAPTEEFEGALETAAVEAAATYINE 3324
                ..|::.:.....|:|.|.....|...|..:      ..|.::..|.      :...:::..
Mouse  3504 ----KPASSASPGSSPSSGQQSGSSSVPGPTKPKPKAKRIQLPLDKGSGK------KHKVSHLRT 3558

  Fly  3325 MADAHV--LDLKQL-QNGVELELRRRKEEQRTVSQEQEQSKAA---IVPTAAAPE---------- 3373
            .::||:  .|.... |..|....|..:|:|.....||...|..   ..|.||.||          
Mouse  3559 SSEAHIPHRDTDPAPQPSVTRTPRANREQQDAAGVEQPSQKECGQPAGPVAALPEVQATQNPANE 3623

  Fly  3374 ----PPQPIQE---------------------------PKKMTGPHLLYEIQSEDGFTYKSSSIT 3407
                .|:.::|                           |||    .|::||.|:|||...:.||.
Mouse  3624 QENAEPKAMEEEESGFSSPLMLWLQQEQKRKESITERKPKK----GLVFEISSDDGFQICAESIE 3684

  Fly  3408 EIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHK 3472
            :.|:.:.:.||.||....|..|   ..|.:.|::|:|:..:|:.:|||||.|.:.|..|..::||
Mouse  3685 DAWKSLTDKVQEARSNARLKQL---SFAGVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRFHK 3746

  Fly  3473 RNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEY 3537
                                                   ..:.:|...|.:..||.|.:..:|.:
Mouse  3747 ---------------------------------------PEEANEPPLNPHGSARAEVHLRKSAF 3772

  Fly  3538 DMFSWLASRHRKQPIQVFVQPSDNE------LVPRRGTGSNLPMAMKYRTLKETYKDYVGVFRSH 3596
            |||::|||:||:.|   ...|:|.|      ...||.|..:|||.|::|.||:|.|:.|||:||.
Mouse  3773 DMFNFLASKHRQPP---EYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSP 3834

  Fly  3597 IHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAA 3661
            ||||||:|.::|:||||||||||.:|||..|||||:||||:|||||||:|||:.||||||.||||
Mouse  3835 IHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAA 3899

  Fly  3662 RFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFED--EKIPCSCGSKRCRKY 3724
            |||||.|||||||:|::|.|.|||:|||:|:|.:|||||||||||.||  .|:||:||:|:|||:
Mouse  3900 RFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKF 3964

  Fly  3725 LN 3726
            ||
Mouse  3965 LN 3966

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:295381 20/122 (16%)
PHD1_KMT2A_like 1268..1344 CDD:276981 19/75 (25%)
PHD 1346..1390 CDD:214584 14/53 (26%)
PHD3_KMT2A_like 1423..1479 CDD:276983 34/58 (59%)
ePHD_KMT2A_like 1737..1841 CDD:277134 52/103 (50%)
FYRN 1891..1935 CDD:283589 15/43 (35%)
FYRC 3388..3476 CDD:197781 31/87 (36%)
SET 3590..3710 CDD:214614 91/121 (75%)
Kmt2aNP_001344478.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..106 33/126 (26%)
Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q03164 6..25 4/18 (22%)
Integrase domain-binding motif 1 (IBM1). /evidence=ECO:0000250|UniProtKB:Q03164 121..132 4/10 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..231 22/113 (19%)
Integrase domain-binding motif 2 (IBM2). /evidence=ECO:0000250|UniProtKB:Q03164 145..150 0/4 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..343 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..590 21/149 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..943 59/288 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 963..1003 11/40 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1064 8/52 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1101..1161 9/60 (15%)
zf-CXXC 1144..1191 CDD:251032 3/46 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1196..1390 25/193 (13%)
PHD1_KMT2A 1432..1478 CDD:277063 19/75 (25%)
PHD2_KMT2A 1480..1529 CDD:277065 14/53 (26%)
PHD3_KMT2A 1567..1626 CDD:277067 34/58 (59%)
Interaction with histone H3K4me3. /evidence=ECO:0000250|UniProtKB:Q03164 1583..1599 11/15 (73%)
Bromo_ALL-1 1649..1779 CDD:99925 33/171 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1665..1714 9/90 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1807..1870 9/74 (12%)
ePHD_KMT2A 1873..1985 CDD:277163 54/114 (47%)
FYRN 2026..2073 CDD:310506 18/49 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2147..2174 4/26 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2214..2339 32/141 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2371..2619 48/278 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2639..2673 2/33 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2709..2759 5/49 (10%)
9aaTAD. /evidence=ECO:0000250|UniProtKB:Q03164 2843..2851 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2958..3060 19/113 (17%)
Herpes_BLLF1 <3152..>3361 CDD:330317 38/226 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3164..3239 12/88 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3462..3640 35/193 (18%)
FYRC 3666..3749 CDD:197781 31/124 (25%)
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q03164 3759..3764 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3782..3805 6/25 (24%)
SET 3828..3948 CDD:214614 90/119 (76%)