DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trx and Tcf20

DIOPT Version :9

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:NP_001107612.1 Gene:Tcf20 / 21411 MGIID:108399 Length:1987 Species:Mus musculus


Alignment Length:2012 Identity:376/2012 - (18%)
Similarity:623/2012 - (30%) Gaps:708/2012 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PGKPSKSINRKRISVL------QLEDDAANPAEPQQPAPESQQPSGSGSGSSAAREKGNNCDNDE 65
            ||..|.|....:::.|      .|..||..|.:     ..|::||.|.       :|.::|.|.|
Mouse   479 PGLSSLSALSSQVANLPNTVQHMLLSDALTPQK-----KTSKRPSSSS-------KKADSCTNSE 531

  Fly    66 DDN-------APGGASISGNTASSSAGSGN-----SGNGSSSGSSTGSGSS---GSGSTNGGSVN 115
            ..:       :|...|:.|..:|||...|.     ||..:||.::...|:|   ||..|.|.   
Mouse   532 GSSQPEEQLKSPMAESLDGGCSSSSEDQGERVRQLSGQSTSSDTTYKCGASEKAGSSPTQGA--- 593

  Fly   116 GGTHHKSAANLDKEAVTKDQNGDGDKTRGNVSSAPSGKLSAAASGKALSKSSRTFSASTSVTSSG 180
                ...|..|.....|:|:.........::||..:.|::....|..:|:.:.|....   .|.|
Mouse   594 ----QNEAPRLSTSPATRDEAASPGAKDTSLSSEGNTKVNEKTVGVIVSREAMTGRVE---KSGG 651

  Fly   181 RSSGSSPDGNSGASSDGASSGISCGKST-----------AKSTEASSGKLAKTTGAGTCSSAKSS 234
            :..||..|..:.:....::||:.....|           :|..:......:...|.|...|:.|:
Mouse   652 QDKGSQEDDPAASQRPPSNSGVKEISHTSLPQPDPPGGGSKGNKNGDNNSSNHNGEGNGPSSHSA 716

  Fly   235 KASS--GTTSEATTSGLSGACLKALF-VATPATSTGLACALVSPGGSSQG--GTFPISAALLRAR 294
            ...|  |.|..:.:.|......|..| .|.|...:|..   ..|.|..:|  |:.       ..|
Mouse   717 VGPSFTGRTEPSKSPGSLRYSYKESFGSAVPRNVSGYP---QYPSGQEKGDFGSH-------GER 771

  Fly   295 KNSNKKFKNLNLARGEVMLPSTSKLKQLNSPVVDNPSPSPPIASGSTPSVEGGIGVGGVVSPGED 359
            |..|:||.:|              |:::......:|....|.::.....:..|:         |.
Mouse   772 KGRNEKFPSL--------------LQEVLQGYHHHPDRRYPRSAQEHQGMASGL---------EG 813

  Fly   360 AALKRVLTEMPNEVARDPSPSSCTAAANGAASGK-GSASNGPPAMASSGDGSSPKSGADTGP--S 421
            .|...:|....||:           |:.|..:.. ||....|                ..||  .
Mouse   814 TARPNILVSQTNEL-----------ASRGLLNKSIGSLLENP----------------HWGPWER 851

  Fly   422 TSSTTAKQKKTVTFRNVLETSDDKSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYSRGGECIVRPS 486
            .||:||.:.|.:..       .|..:.::|   :|..|       .|.:.|     ||....|.|
Mouse   852 KSSSTAPEMKQINL-------SDYPIPRKF---EIEPP-------SSAHEP-----GGSLSERRS 894

  Fly   487 ILSKILNKNSNIDKLNSLKFRSAGASS---SSSNQESGSSSNVF-GLSRAFGAPMDEDDEGGVTF 547
            ::       .:|..|..: .|..||.|   ..::...|.:..:. .||::...|      ||:. 
Mouse   895 VI-------CDISPLRQI-VRDPGAHSLGHMGTDARIGRNERLNPSLSQSVILP------GGLV- 944

  Fly   548 RRNDSPEDQNNAEDDEMDDDDDDEEAEEDDENEDDNDE----AVSEKSAETEKSAGADERDPDEK 608
                |.|.:..::..::.::|.::...:...|:...|.    ::..::.....|.||...|....
Mouse   945 ----SMETKLKSQSGQIKEEDFEQSKSQASFNKKSGDHCHPTSIKHETYRGNASPGAAAHDSISD 1005

  Fly   609 QLVMDSHFVLPKRSTRSSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGTSSSSAGSTASTFS 673
            ....||      |||...|:         .|.:.:::.:.          |.|||.....|....
Mouse  1006 YGPQDS------RSTPMRRV---------PGRVGSRETMR----------GRSSSQYHDFAEKLK 1045

  Fly   674 ASTNLKLGKETFFNFGTLKPNSSAAGNFVLRQPRLQFQADNQQATFTAPKACPTSPSAIPKPANS 738
            .|.....|                                               |...|...|.
Mouse  1046 MSPGRSRG-----------------------------------------------PGGDPHHMNP 1063

  Fly   739 LATSSFGSLASTNSSTVTPTPSACSICSAVVSSKEVTQARKYGVVACDV------CRKFFSKMTK 797
            ..|  |...|:.:|.....:|::.|:.||..::   |:|..||.....:      .|:.:.:..:
Mouse  1064 HMT--FSERANRSSLHAPFSPNSESLASAYHTN---TRAHAYGDPNTGLNSQLHYKRQMYQQQQE 1123

  Fly   798 KSISANSSTANTSSGSQQYLQCKGNEGSPCS---IHSAKSQLKNFKK---------FYKDRCTAC 850
            :.....||:|.....:.|:.| :|...||..   :...:|.|||.|.         .|.|..|. 
Mouse  1124 EYKDWASSSAQGVIAAAQHRQ-EGPRKSPRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDPSTQ- 1186

  Fly   851 WLKKCMISFQ-LPAAHRSRLSAILPPGMRGEAAAREEKSAELLSPTGSL--------RFTSTASS 906
            ...:|::|.. |||                       ||.||...:..|        |.||.|.|
Mouse  1187 EAGRCLMSSDGLPA-----------------------KSMELKHSSQKLQESCWDLSRQTSPAKS 1228

  Fly   907 SSPSVVASTSVKW------KSSGDSTSALTSIKPN------PLAENNVTFGSTPLLRPAILENPL 959
            |.|..: |...::      ...|.:.||.:| ||:      |..|::.:            :|||
Mouse  1229 SGPPGM-SNQKRYGPPHEPDGHGLAESAQSS-KPSNVMLRLPGQEDHSS------------QNPL 1279

  Fly   960 FLKISNAADQKLAAAEAISPSLTKKNSKQEKEKVKESEQSEK--LLSPTQAGTKKSGAAEAQVEE 1022
            .:        :......|||.    .||::.:.||.|...:|  ||.|::.|..|:..:.:.:..
Mouse  1280 IM--------RRRVRSFISPI----PSKRQSQDVKNSNADDKGRLLHPSKEGADKAYNSYSHLSH 1332

  Fly  1023 VQPQKEEAPQTSTTTQPSASNGASHGVPQAELAGETNA------TGDTLKRQRI--DLKGPRVKH 1079
            .|..|....:.|:...|:..|   ...|...|......      .|..||.:.|  .:..|.::.
Mouse  1333 SQDIKSIPKRDSSKDLPNPDN---RNCPAVTLTSPAKTKILPPRKGRGLKLEAIVQKITSPNIRR 1394

  Fly  1080 VCRSASIVLGQPLATFGE-----DQQPE------DAADMQQ---EIAAPVPSAI-MEPSPEKPTH 1129
            ...:.|...|....|..:     ...||      ..|:|::   |:.:.:.|.. .|.:.|||..
Mouse  1395 SASANSAEAGGDTVTLDDILSLKSGPPEGGTVATQEAEMEKRKCEVVSDLVSVTNQESNVEKPLP 1459

  Fly  1130 IVTDE-----NDNC---ASCKTSPVGDESKPSKSSGSAQAEVKKATALGKEGTASAAGGSSAKV- 1185
            ..::|     :|..   |..:|:..|.|...:.:|.::|...      |.:|....:.|.:|.: 
Mouse  1460 GPSEEWRGSGDDKVKTEAHVETASTGKEPSGTMTSTASQKPG------GNQGRPDGSLGGAAPLI 1518

  Fly  1186 --TTRNAAVASNLIVAASKK--QRNGDIATSSSVTQS--------SNQTQGR------------- 1225
              .::|.|....|...|:.|  ::..|....|...:|        |.:.:||             
Mouse  1519 FPDSKNVAPVGILAPEANPKAEEKENDTVMISPKQESFPPKGYFPSGKKKGRPIGSVNKQKKQQQ 1583

  Fly  1226 --------------------KTKEHRQQRTLISIDFWENYDPAEVCQTGFGLIVTETVAQRALCF 1270
                                |.|:.||:|        |...|        |....:...::|:  
Mouse  1584 QPPPPPQPPQMPEGSADGEPKPKKQRQRR--------ERRKP--------GAQPRKRKTKQAV-- 1630

  Fly  1271 LCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQ 1335
                    |::      ||.     :.|..||:.:            ..::.:...:.|......
Mouse  1631 --------PIV------EPQ-----EPEIKLKYAT------------QPLDKTDAKNKSFFPYIH 1664

  Fly  1336 RLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTC---LGTSKRLLGADR-----PLICVNCLK 1392
            .:| .|....||...|.....:.|..:.:|...|..   ..|..::|.|..     |::      
Mouse  1665 VVN-KCELGAVCTIINAEEEEQTKLVRSRKGQRSLTPPPSSTESKVLPASSFMLQGPVV------ 1722

  Fly  1393 CKSCSTTKVSKFVGNLPMCTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGL 1457
                   ..|..:|:|..|.                                 ||:|        
Mouse  1723 -------TESSVMGHLVCCL---------------------------------CGKW-------- 1739

  Fly  1458 SDEQYNLLSTLPESIEFICKKCARRNESSKIKAEEWRQAVMEEFKASLYSVLKLLSKSRQACALL 1522
                                 .:.||              |.:.....|       ....|..|.
Mouse  1740 ---------------------ASYRN--------------MGDLFGPFY-------PQDYAATLP 1762

  Fly  1523 KLSPRKKLRCTCGASSNQGKLQPKALQFSSGSDNGLGSDGESQNSDDVYEFKDQQQQQQQRNANM 1587
            |..|.|:      :|..|.|::.:....|:||            ..|..|.::||||::||:...
Mouse  1763 KNPPPKR------SSEMQSKVKVRHKSASNGS------------KTDTEEEEEQQQQKEQRSLAA 1809

  Fly  1588 NKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSYVSLAEFNYDMSQVIQQSNCDELDIAYKEL 1652
            : ||.|      ::|.|..            .|....|                           
Mouse  1810 H-PRFK------RRHRSED------------CGGGPRS--------------------------- 1828

  Fly  1653 LSEQFPWFQNETKACTDALEEDMFESCSGGNYEDLQDTGGVSASVYNEHSTSQA--ESRSGVLDI 1715
            ||...|        |..|..|       |.:.:.:.||   ..||   .:||:.  |....:.::
Mouse  1829 LSRGLP--------CKKAATE-------GSSEKTVSDT---KPSV---PTTSEGGPELELQIPEL 1872

  Fly  1716 PLEEVDDFGSCGIKMRLDTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDG 1780
            ||:                                       .::.|||..|.:|:..:: .:.|
Mouse  1873 PLD---------------------------------------SNEFWVHEGCILWANGIY-LVCG 1897

  Fly  1781 SLQNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDCAFLTDK-SMYCPAH 1841
            .|..:..|:...|.:||:.|...|||:||..:.|...||||||...||....:. |:.||.|
Mouse  1898 RLYGLQEALEIAREMKCSHCQEAGATLGCYNKGCSFRYHYPCAIDADCLLHEENFSVRCPKH 1959

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:295381 24/111 (22%)
PHD1_KMT2A_like 1268..1344 CDD:276981 9/75 (12%)
PHD 1346..1390 CDD:214584 10/51 (20%)
PHD3_KMT2A_like 1423..1479 CDD:276983 3/55 (5%)
ePHD_KMT2A_like 1737..1841 CDD:277134 29/104 (28%)
FYRN 1891..1935 CDD:283589
FYRC 3388..3476 CDD:197781
SET 3590..3710 CDD:214614
Tcf20NP_001107612.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..432
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..481 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..816 76/368 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 844..891 16/84 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 949..1065 24/187 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1136..1372 63/289 (22%)
Leucine-zipper 1198..1219 8/43 (19%)
Nuclear localization signal 1282..1295 3/16 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1415..1434 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1446..1636 39/227 (17%)
Nuclear localization signal 1604..1628 8/39 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1685..1710 4/24 (17%)
ePHD_TCF20 1733..1959 CDD:277169 79/433 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1760..1865 38/189 (20%)
Nuclear localization signal 1812..1819 3/12 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1966..1987
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1084
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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