DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and Rai1

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	NP_001032853.1	Gene:	Rai1 / 19377	MGIID:	103291	Length:	1889	Species:	Mus musculus

Alignment Length:	2165	Identity:	393/2165 - (18%)
Similarity:	616/2165 - (28%)	Gaps:	835/2165 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 SGISCGKS--TAK---STEASSGKLAKT-TGAGTCSSAKSSKASSGTTSEATTSGLSGACLKALF 258
            :|:||.:.  .||   |.:..:|....| |.:||.::|.:.|...|:.|      |.|......:
Mouse    36 AGLSCDRQRLLAKDYYSPQPYTGYEGGTGTPSGTVATAAADKYHRGSKS------LQGRPAFPSY 94

  Fly   259 VAT----PATSTGLACALVSPGGSSQGG-------TFPISAALLRARKNSNKK------------ 300
            |..    |...:|      ..|..:.||       ..|:..|:.:..:|..||
Mouse    95 VQDSSPYPGRYSG------EEGLQTWGGPQPPPPQPQPLPGAVSKYEENLMKKTVVPPPNRQYPE 153

  Fly   301 ------FK--NLNLARGEVMLPSTSKLKQLNSPVVDNPSPSP--------------PIASGSTPS 343
                  |:  :|::...:...|......|...|..|..||.|              |.:|...|:
Mouse   154 QGPQLPFRTHSLHVPPPQPQQPLAYPKLQRQKPQNDLASPLPFPQGSHFPQHSQSFPTSSTYAPT 218

  Fly   344 VEGGIGVGGVVSPGEDAALKRVLTEMPNEVARDPSPSSCTAAANG-------------------- 388
            |:||         |:.|...:..| .|:....|...|:....|.|
Mouse   219 VQGG---------GQGAHSYKSCT-APSAQPHDRPMSANANLAPGQRVQNLHAYQPGRLGYEQQQ 273

  Fly   389 -AASGK------------------GSASNG--PPAMA-----------SSGDGSSPKSGADTGPS 421
             |..|:                  |....|  ||..|           |.....||.......||
Mouse   274 QALQGRHHTQETLHYQNLAKYQHYGQQGQGYCPPDTAVRTPEQYYQTFSPSSSHSPARSVGRSPS 338

  Fly   422 TSSTTAKQKKTVT----FRNVLETS------DDKSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYS 476
            .|||.:.....:.    .:..|.|.      .|.|......||.   |..:....|        .
Mouse   339 YSSTPSPLMPNLENFPYSQQPLSTGAFPTGITDHSHFMPLLNPS---PTDAASSVD--------P 392

  Fly   477 RGGECIVRPSILSKILNKNSNIDK-LNSLKFRSAGASSSSSNQESGSSSNVFGLSRAFGAPMDED 540
            :.|.|        |.|.|....|. |:.|..:|..|.:|.....|.:...:. ||:|     ...
Mouse   393 QAGNC--------KPLQKEKLPDNLLSDLSLQSLTALTSQVENISNTVQQLL-LSKA-----TMP 443

  Fly   541 DEGGVTFRRNDSPEDQNNAEDDEMDDDDDDEEAEEDDENEDDNDEAVSEKSAETEKSAGADERDP 605
            .:.||....:.:||...:...          ..|....:.:.....:||..:.|.:|..|:.:|.
Mouse   444 QKKGVKNLVSRTPEQHKSQHC----------SPEGSGYSAEPAGTPLSEPPSSTPQSTHAEPQDT 498

  Fly   606 D---EKQLVMDSHFVLPKRSTRSSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGTSSSSAGS 667
            |   ..:..::..|:...::..|...:..|.:...| ::||....|..|...|     |..|..|
Mouse   499 DYLSGSEDPLERSFLYCSQARGSPARVNSNSKAKPE-SVSTCSVTSPDDMSTK-----SDDSFQS 557

  Fly   668 TASTFSASTNLKLGKETFFNFGTLKPNSSAAGNFVLRQ-PRLQFQA------------------- 712
            ..||        |..::|..|        .||.   |. |||...|
Mouse   558 LHST--------LPLDSFSKF--------VAGE---RDCPRLLLSALAQEDLASEILGLQEAIVE 603

  Fly   713 --------------DNQQATFTAPK--AC-----------PTSPSAIPKPANSLATSSFGSLAST 750
                          ||.:..|:...  ||           |..|..:|:|..          ...
Mouse   604 KADKAWAEASSLPKDNGKPPFSLENHGACLDTVAKTSWSQPGEPETLPEPLQ----------LDK 658

  Fly   751 NSSTVTPTPSAC---SICSAVVSSKEVTQARKYGVVACDVCRKFFSKMTKKSISA------NSST 806
            ..||...:|...   |:..|....|:.:....:|.      :......|....:|      ::.|
Mouse   659 GGSTKDFSPGLFEDPSVAFATTDPKKTSSPLSFGT------KPLLGTATPDPTTAAFDCFPDTPT 717

  Fly   807 ANTSSGSQQYLQCKGNEGSPCSIHSAKSQLKNFKKFYKDRCTACWLKKCMISFQLPAAHRSRLSA 871
            |::..|:..:...:.|.|..|                     ..|           ..|...|:.
Mouse   718 ASSVDGANPFAWPEENLGDAC---------------------PRW-----------GLHPGELTK 750

  Fly   872 ILPPGMR-----GEAAAREEKSAELLSPTGSLRFTSTASSSSPSVVASTSVKWKSS-------GD 924
            .|..|.:     |:|.|.|..:.        :.|....:...|:...|...|.:.:       |.
Mouse   751 GLEQGAKASDGVGKADAHEASAC--------MGFQEDHAIGKPAAALSGDFKQQEAEGVKEEVGG 807

  Fly   925 STSALTSIKPNPLAE------NNVTFGSTPLLRP--------AILENPLFLKISNAADQKLAAAE 975
            ........|.|...|      ::..||..|||.|        |..|.....::..:.:|:.:..:
Mouse   808 LLQCPEVAKANQWLEESRHCCSSTDFGDLPLLPPPGRKEDLEAEEEYSSLCELLGSPEQRPSLQD 872

  Fly   976 AISPSLTKKNSKQEKEKVKE-----------SEQSEKLLSPTQAGTKK------SGAAEAQVEEV 1023
            .:||......:|:|.|:..:           |.:...||.|:.....|      |..:..:..|.
Mouse   873 PLSPKAPLMCTKEEAEEALDTKAGWVSPCHLSGEPAVLLGPSVGAQSKVQSWFESSLSHMKPGEE 937

  Fly  1024 QPQKEEAPQTSTTTQPS-ASNGASHGVPQAELA-GETNATGDTLKRQRIDLKGPRVK-HVCRSAS 1085
            .|:.|.||.:|.|:|.| |.......||:..:| .|....|.:|:.:|:....|..: ..||..:
Mouse   938 GPEMERAPGSSGTSQGSLAPKPNKPAVPEGPIAKKEPVPRGKSLRSRRVHRGLPEAEDSPCRVPA 1002

  Fly  1086 IV--LGQPLATFGEDQ-QPEDAADMQQEIAAPVP-------SAIMEPSPEKPTHIVTDENDNCAS 1140
            :.  |..|.:..|..| |.|.|....:.::..:|       :|:.||....|..:.
Mouse  1003 LPKDLLLPESCTGPPQGQAEGAGAPGRGLSEGLPRMCTRSLTALSEPQTPGPPGLT--------- 1058

  Fly  1141 CKTSPVGDESKPSKSSGSAQAEVKKATALGKEGTASAAGGSSAKVTTRNAAVASNLIVAASKKQR 1205
              |:|    :.|.|..|..:|..|....:||....:|:..|:.      ||:
Mouse  1059 --TTP----TPPDKLGGKQRAAFKSGKRVGKPSPKAASSPSNP------AAL------------- 1098

  Fly  1206 NGDIATSSSVTQSSNQTQGRKTKE-------HRQQRTLISIDFWENYDPAEVCQTGFGLIVTETV 1263
              .:|:.||       ..|.||||       .:.||:::                    :.:.|.
Mouse  1099 --PVASDSS-------PMGSKTKEPDSPSMPGKDQRSMV--------------------LRSRTK 1134

  Fly  1264 AQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSL-----LETTVNAS 1323
            .|:              :|.|....|            ......|......|     |.|....|
Mouse  1135 PQQ--------------VFHAKRRRP------------SESRIPDCRATKKLPANNHLPTAYKVS 1173

  Fly  1324 TGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRPLICV 1388
            :||     |...|:|                 .:||..|         .||..:|  :||||
Mouse  1174 SGP-----QKEGRMN-----------------QRVKVPK---------PGTGNKL--SDRPL--- 1202

  Fly  1389 NCLKCKSCSTTKVSKFVGNLPMCTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSK 1453
            :.||.||.       |:..:|.......||....                    .|..|:...::
Mouse  1203 HTLKRKSA-------FMAPVPAKKRSLILRSNNG--------------------SGGDGREERAE 1240

  Fly  1454 ----------------------------------CEGLSDEQYNLLSTLPESI------------ 1472
                                              |.|||.:     |:||.::
Mouse  1241 SSPGLLRRMASPQRARPRGSGEPPPPPPLEPPAACMGLSTQ-----SSLPSAVRTKVLPPRKGRG 1300

  Fly  1473 ---EFICKKCA--------------------------RRNESSKIKAEE---------------- 1492
               |.|.:|..                          ||...|...|||
Mouse  1301 LKLEAIVQKITSPGLKKLACRVAGAPPGTPRSPALPERRPGGSPAGAEEGLGGMGQMLPAASGAD 1365

  Fly  1493 --WRQAVMEEFKASLYSVLKLLSKSRQACALLKLSP----------------RKKLRCTCG---- 1535
              .|.......|..|.:..||.|.:....|...:||                ||....|.|
Mouse  1366 PLCRNPASRSLKGKLLNSKKLSSAADCPKAEAFMSPETLPSLGTARAPKKRSRKGRTGTLGPSKG 1430

  Fly  1536 -------------------ASSNQGKLQPKALQFSSGSDNGLGSD--------GESQNSDDVYEF 1573
                               |||.||          .|.||..|..        |.:....:....
Mouse  1431 PLEKRPCPGQPLLLAPHDRASSTQG----------GGEDNSSGGGKKPKTEELGPASQPPEGRPC 1485

  Fly  1574 KDQQQQQQQ----------RNANMNKPRVKSL---PC---------------------------- 1597
            :.|.:.|:|          :...:::.|.|:.   ||
Mouse  1486 QPQTRAQKQPGQASYSSYSKRKRLSRGRGKTAHASPCKGRATRRRQQQVLPLDPAEPEIRLKYIS 1550

  Fly  1598 SCQ--QHISHSQSFS-LVDIKQKIAGNSYVSLAEFNYD---------MSQVIQQSNCDELDIAYK 1650
            ||:  :..|.:.:|| .|.::::.|..:..::.....|         .|.....::...|:.|..
Mouse  1551 SCKRLRADSRTPAFSPFVRVEKRDAYTTICTVVNSPGDEPKPHWKPSSSAASSSTSSSSLEPAGA 1615

  Fly  1651 ELLS-------EQFPWFQNET-----KACTDALEEDMFESCSGGNYEDLQDTGGVSASVYNEHST 1703
            .|.:       :|.|.....:     ...:.||.......|...|..:.:|.|.:....|.||..
Mouse  1616 SLTTFPGGSVLQQRPSLPLSSTMHLGPVVSKALSTSCLVCCLCQNPANFKDLGDLCGPYYPEHCL 1680

  Fly  1704 SQAESR-------SGVLD---IPLEEVDDFGSC-------------------------------- 1726
            .:.:.:       .|.|:   :|||.......|
Mouse  1681 PKKKPKLKEKARLEGTLEEASLPLERTLKGLECSASTTAAAPTTATITTPTALGRLSRPDGPADP 1745

  Fly  1727 -----------GIKMRLDTRMCLFCRKSGEGLSGEE------ARLLYCGHDC------------- 1761
                       |:..||.:  |..|  .|:|..|||      :|    .|:|
Mouse  1746 AKQGPLRTSARGLSRRLQS--CYCC--DGQGDGGEEVAQADKSR----KHECSKEAPTEPGGDTQ 1802

  Fly  1762 --WVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCAR 1824
              |||..||:|::.|: .:.|.|..:..|:.....:.||.|...|||:.|:.:.|...||||||.
Mouse  1803 EHWVHEACAVWTSGVY-LVAGKLFGLQEAMKVAVDMPCTSCHEPGATISCSYKGCIHTYHYPCAN 1866

  Fly  1825 SIDCAFLTDK-SMYCPAHAK 1843
            ...|.|:.:. ::.||.|.:
Mouse  1867 DTGCTFIEENFTLKCPKHKR 1886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381	13/102 (13%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	13/80 (16%)
		PHD	1346..1390	CDD:214584	10/43 (23%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	11/104 (11%)
		ePHD_KMT2A_like	1737..1841	CDD:277134	38/125 (30%)
		FYRN	1891..1935	CDD:283589
		FYRC	3388..3476	CDD:197781
		SET	3590..3710	CDD:214614
Rai1	NP_001032853.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..130		18/88 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..248		21/114 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..365		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..401		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..505		12/68 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..554		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..698		11/74 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	922..1297		98/531 (18%)
		PHA03247	<939..1375	CDD:223021	106/592 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	1143..1160		2/28 (7%)
		Nuclear localization signal. /evidence=ECO:0000255	1206..1223		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1322..1539		36/226 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1583..1614		3/30 (10%)
		PHD_SF	1655..1884	CDD:419867	54/237 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1720..1753		0/32 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810