|
Fly 996 SEQSEKLLSPTQAGTKKSGAAEAQVEEVQPQKEEAPQTSTTTQPSASNGASHGVPQAELAGETNA 1060
|.:|...::|....:|:....|...||..|:|....: .|:....:|::....|..:. |||.
Mouse 19 SRKSPSTINPGTLASKREAEIEGATEEEDPRKRNRER---GTEAGKEDGSTDAQQQFSVK-ETNF 79
Fly 1061 TGDTLKRQRIDLKGPRVK--------HVCRSASIVLGQPLATFGEDQQPEDAADMQQEIAAPVPS 1117
:...|| .:|.|:..|.| :|||.| :.:
Mouse 80 SEGNLK-LKIGLQAKRTKKPPKNLENYVCRPA------------------------------IKT 113
Fly 1118 AIMEPSPEKPTHIVTDE-NDNCASCKTSPVGDESKPSKSSGSAQA---EVKKATALGKEGTASAA 1178
.|........:..:||| |::|.| ..|.||..|.:|.|.| :.:::..|..:|
Mouse 114 TIKHSRKALKSGKMTDEKNEHCPS-----KWDSSKLFKKAGDATAIDCQAEESIHLHSQG----- 168
Fly 1179 GGSSAKVTTRNAAVASNLIVAASKKQRNGDIATSSSVTQSSNQTQGRKTKEHRQQRTLISIDFWE 1243
.||....:.:..|.|....||
Mouse 169 ---------------------------------------ESNPLSKKLSPVHSQMADYIS----- 189
Fly 1244 NYDPAEVCQTGFGLIVTETVAQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFED 1308
|...|.||. || ..:|
Mouse 190 -----------------------AAPSLVGSR--DP-------------------------DIKD 204
Fly 1309 TTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLG 1373
..|: |..|..:..|.||.. ||..|..||.|.:| ||
Mouse 205 RALL--------NGGTSVTEKLAQLIA-------------TCPPSKSSKAKPKK---------LG 239
Fly 1374 T-------SKRLL-----GADRPLICVNCLKCKSCSTT--KVSKFVGNLPMCTGCFKLRKKGNFC 1424
| ||.|: |:...:|..:.:|..:.||. .|:|..|..||......|..|.:
Mouse 240 TGTTVGLVSKDLIRKPGVGSIAGIIHKDLIKKPALSTAVGLVTKDPGKKPMFNAAVGLINKDS-- 302
Fly 1425 PICQRCYDDNDFDLKMMECGDCGQWVHSKCEGLSDEQYNLLSTLPESIE---FICKKCARR---- 1482
:|.:..|....:::.. |...|.:|. .:.|:..::
Mouse 303 -------------VKKLGTGTTAVFINKD-----------LGKKPGAITTVGLLSKESGKKLGIG 343
Fly 1483 -------NESSKIKAEEWRQAVMEEFKASLYSVLKLLSKSRQACALLKLSPRKKLRCTCG----- 1535
.||.| |..|.:|:.|::|.. .|||..|.|
Mouse 344 IVPGLVNKESGK--------------KLGLGTVVGLVNKEL----------GKKLSSTVGLVAKD 384
Fly 1536 ------ASSNQGKLQ----------PKALQFSSGSDNGLGSDGESQNSDDVYEFKDQQQQQQQRN 1584
|||..|.:. |.|.|. ||.:.|....|:.
Mouse 385 VTKKIVASSAMGLVNKDIGKKLLNCPMAGQL--GSKDALNLKSEAL------------------- 428
Fly 1585 ANMNKPRVKSLPCSCQQHISHSQSFSLVD-IKQKIAGNSYVSLAEFNYDMSQVIQQSNCDELDIA 1648
.|..:.|..||..:||:..|..|.: :|....|.: |...:.:..::|..::..:.
Mouse 429 ----LPTQEQLKASCSANISNHDSQELPESLKDSATGKA------FEKSVMRHSKESMLEKFSVR 483
Fly 1649 YKELLSEQFPWFQNETKACTDALEEDMFESCSGGNYE---------------DLQDTGGVSASVY 1698
||:.:.:...|...| .:::|.|.|...|.:| |.|..|...||..
Mouse 484 -KEITNLEKEMFNEGT-----CIQQDNFSSSERGAFETSKHEKQPPVYCTSPDFQIGGASDASTA 542
Fly 1699 NEHSTSQAESRSGVLDIPLEEVDDFGSCGIKMRLDTRMCLFCRKSGEGLSGEEARLLYCGHDCWV 1763
....::..|| ::| ..|..:.:...|| |..||......:...:
Mouse 543 KSPFSAVGES-----NLP------SSSPTVSVNPVTR------------SPPEASSQLVPNPLLL 584
Fly 1764 HTNCAMWSAEVFEEIDGSL-------QNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYP 1821
:: :||..|||..|: ::.|..|.. ||.|.
Mouse 585 NS-----TAEQMEEISESIGKSQFTAESTHLNVGH--------------------RSLGH----- 619
Fly 1822 CARSIDCAFLTDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVELDRKRKKLIEPARVQ 1886
:.||:|..: || ||:..:...::..|:.
Mouse 620 -SLSIECKGI-DK------------------------------------ELNESKNTHLDIPRIS 646
Fly 1887 FHIG---SLEVRQLGAIVPRFSDS-YEAVVP--INFLCSRLYWSSKEPWKIVEYTVRTTIQNSSS 1945
..:| ||. ||| ..|:.| :||.. .:|:|...|: .
Mouse 647 SSLGKKPSLT-----------SDSGIHAITPSVVNFTS---LFSNKPFLKL-------------G 684
Fly 1946 TLTALD----VGRNYTVDHTNPNSKEVQLGMAQIARWHTSLARSEFLENGGTDW--SGEFPNPNS 2004
.:||.| |..:.: ::..||.::....:..||...:|||......|.|. |..|.|. |
Mouse 685 AVTAPDKHCQVAESLS---SSFQSKPLKKRKGRKPRWTKVVARSTCRSPKGLDLERSELFKNV-S 745
Fly 2005 CVPPDENTEEEPQQQADLLPPELKDAI----FEDLPHELLDGISMLDIFLYDDKTDLFAISEQSK 2065
|.....::| |.:....| |.| |:.| |..|..:|:.|.
Mouse 746 CSSLSNSSE----------PAKFMKTIGASSFVD--HDFL-------------KRRLPKLSKSSA 785
Fly 2066 DGTQAMTSNQAQNQNQQAGGANSVSIC-DEDTRNSNTSLGNGWPASNPVEDAMLSAARNSSQVQM 2129
.....:|.::..:.........|.|:| ..|..:.......|.|.|..:
Mouse 786 PSLALLTDSEKPSHKSFITHKLSSSMCVTSDLLSDIYKPKRGRPKSKEM---------------- 834
Fly 2130 LKTLAWPKLDGNSAMATAIKRRKL----SKNLAEGVFLTLSSQQRNKKEMATVA------GVSRR 2184
|:|:|.......|...|: ||...|...|....:..:.|:..:|: |..:|
Mouse 835 ------PQLEGPPKRTLKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQSLSVSPFPKKRGRPKR 893
Fly 2185 QSISETSVEG--------VATTSGS-VRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSI 2240
|..|...::. |||.|.| :.|:|....::..:||..: ::...|.:|||
Mouse 894 QMRSPVKMKPPVLSVAPFVATESPSKLESESENHRSSSDFFESED--------QLQDTDDLDDS- 949
Fly 2241 TEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDAFQRHLPS-CSPTMSSNETESDVSGQGMTNN 2304
|..| || ||..|.|.|
Mouse 950 --------------------------------------HRQSVCS--MSDLEMEPD--------- 965
Fly 2305 ATQISAESLNELQKQLLANAGGLNYLQSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSLGSGFFL 2369
.:||..:..:|.|.::.....:..|:......|: |.|..:...:|..|.:|.
Mouse 966 -KKISKRNNGQLMKTIIRKINKMKTLKRKKLLNQI--LSSSVESSNKGKVQSKLH---------- 1017
Fly 2370 SQPNPATQANTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQPQLIAVSTNPDGTQQFIQIPQ 2434
|::.||||..|. .|.| .::.:..||
Mouse 1018 ------------------NTVSSLAATFGS--KLGQ------------QINVSKKGT-------- 1042
Fly 2435 TMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPLKTVATKAAQQAAVKQRQLKSGHQVKPIQAK 2499
.|...:.....|.::..|.:.......|..:.||||| |..:..|...
Mouse 1043 ----------IYIGKRRGRKPKTVLNGLLSGSPASLAVLEQTAQQAA--------GSALGQILPP 1089
Fly 2500 LQPHPQQHQQQQQTQVQQPITVMGQNLLQPQLLFQSSTQT--QAP-----QIILPQAQPQNIISF 2557
|.|.|....: :|...:..|||..: |:| ..:.|.:.| :
Mouse 1090 LLPSPASSSE----------------ILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVP-----Y 1133
Fly 2558 VTGDGSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDASGNLVLTTTPSNSGL 2622
:.....||..:|.:::..|.:.:.:..| ||.|..:| |.|
Mouse 1134 LHVHSRQGSMIQTLAMKKASKGRRRLSP---PTLLPNSP-----------------------SHL 1172
Fly 2623 QMLTAQSLQAQPQVIGTLIQPQTI--QLGGGADGNQPGSNQQPLILGGTGGGSSGLEFATTSPQV 2685
..||:.. :|.|..:......:|| ..|.|.|.|......:... |........|..:..|.
Mouse 1173 SELTSLK-EATPSPVSESHSDETIPSDSGIGTDNNSTSDRAEKFC--GQKKRRHSFEHISLIPP- 1233
Fly 2686 ILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQN-ASFSATTTQVFQASKIEPIVDLPAGYV 2749
|| :||::|.:..........|.: .|:.....|..:..| .|.
Mouse 1234 -----------ET---STVLNSLKEKHKHKCKRRSHDYLSYDKMKRQKRKRKK---------KYP 1275
Fly 2750 VLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQF---QSVPTSSGASTSMDYTSPVMV 2811
.|.|..|.. |:.....|..:..:...| :.:..| ..:||....:.:..||.|
Mouse 1276 QLRNRQDPD----FIAELEELISRLSEIRIT----HRSHHFIPRDLLPTIFRINFNSFYTHP--- 1329
Fly 2812 TAKIPPVTQIKRTNAQAKAAGISGVGKVPPQPQVVNKV-------LPTSIVTQQSQVQVKNSNLK 2869
:..:.|:..|::.:.:.|. |:.|...:.:.:: .|.| |.....:..:.
Mouse 1330 SFPLDPLHYIRKPDLKKKR------GRPPKMREAMAEMPFMHSLSFPLS-----STGFYPSYGMP 1383
Fly 2870 QSQVKGKAAS-GTGTTCGAPPSIASKPLQKK-TNMIRPIHKLEVKPKVMKPTPKVQNQNHSLLQQ 2932
.|.....||. |.|.....||::...|.... |..:.|...:.....::.|| |...:.|.||:|
Mouse 1384 YSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHAGHLLLNPT-KYHKKKHKLLRQ 1447
Fly 2933 QQQQQPQLQQQIPAVVVNQVPKVTIS-QQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPS 2996
: ..:..::.|.:::| ...:| .::....|:....:.:...::....||.
Mouse 1448 E-----------AFLTTSRTPLLSMSTYPSVP-----PEMAYGWMVEHKHRHRHKHREHRSEQPQ 1496
Fly 2997 MPIITLAEAPVVQS----QFVME------------------PQALEQQELANRVQHFSTSSSSSS 3039
:.:.:.:...|::| :|..: |.....:.|.||.:.:.:...|.|
Mouse 1497 VSMDSGSSRSVLESLKRYRFGKDTVGDRYKHKEKHRCHMSCPHLSPSKNLINREEQWVSREPSES 1561
Fly 3040 SNCSLPTNVVNPMQ----QQAPS----------------------TTSSSTTRPTN--------- 3069
| ||...:..|:| :.:|| |::..:.|.:|
Mouse 1562 S--SLALGLQTPLQIDCSESSPSLSLGGFTPNSEPASSDEHMNLFTSAIGSCRVSNPNSSCRKKL 1624
Fly 3070 ----RVLPMQ-------QRQEPAPLSNECPVVS-------SPTPPK---------PVEQPIIHQM 3107
.:.|:| .|:||.| |:|..:.| |..|.: |..:....:.
Mouse 1625 TDSPGLFPVQDTALNRPHRKEPLP-SSERAIQSLAGSQSASDKPSQRSSESTNCSPTRKRSSSES 1688
Fly 3108 TSASVSKCYAQKSTLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGE 3172
||::|: ...|..|..|...:..|.|:|:.||.....::: |:....||.|......:|||.
Mouse 1689 TSSTVN---GVPSRSPRLVASMDDSVDSLLQRIVHHDEQESM--EKNGDASITTVSAPPSSSPGH 1748
Fly 3173 SKTEQLLLQQQQREQLNQQLVNNGYLLDKHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSA 3237
|.:::..|.:.. :..|..:..|......|..|: :.|.
Mouse 1749 SYSKERALGKSD------------------SLLVPAVPNDSCSNIPLLSEK----------SASR 1785
Fly 3238 CNDHEMSDSEEPAVKDK------ISKILDNLTNDDCADSIATATTMEVDASAGYQ---------- 3286
|:.|.:..|...|::.: ..|||....|.|..:.|..|..::..|..|..
Mouse 1786 CSPHHIKRSVVEAMQRQARKMCNYDKILATKKNLDHVNKILKAKKLQRQARTGNNFVKRRPGRPR 1850
Fly 3287 ----QMVEDVLATTAAQSAPTEEFEGA---------LETAAVEAAATYINEMADAHVLDLKQLQN 3338
|.|..:.|..|||....|..||. ..|..:||....:| :...|...:|: :|
Mouse 1851 KCPLQAVVSMQAFQAAQFVSPELNEGEDMSLHLSPDTVTDVIEAVVQSVN-LTSEHKKGVKR-KN 1913
Fly 3339 GVELELRRRKEEQRTVSQEQEQ-SKAAIVPTAAAPEPPQPIQEPKKMTGPHLLYEIQSEDGFTYK 3402
.:..|..|:| |:||.:|:|| :..:.:.|.. |.|.|::.|.:.:.|
Mouse 1914 WLLEEQTRKK--QKTVPEEEEQENNKSFIETPV--EIPSPLETPAEPSEP--------------- 1959
Fly 3403 SSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYT 3467
|...:.|..........|.|........|:.....||...|..:.||. .||. :||
Mouse 1960 --------ENTLQPVLALIPREKKAPRPPKKKYQRAGLYSDVYKTIDPKSRLIQLK-KEKL-EYT 2014
Fly 3468 PKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCEPYS 3532
|..| :||.....:....| .|.:...
Mouse 2015 PGEH--------------------------------------EYGLFPAPIHVGKY--LRQKRID 2039
Fly 3533 NRSEYD-MFSWLASRHRKQP-----------IQVFVQP-------------SDNELVPRRGTGSN 3572
.:..|| ::.|..::..|:| :.|.|:| .|:: .|:|.|.:
Mouse 2040 FQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVKPLSGYEATTCNCKKPDDD--TRKGCGDD 2102
Fly 3573 LPMAMKY-----------------RTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGE 3620
....|.: |..:..:...:..||:...|.|:...:.::||:.:|||.||
Mouse 2103 CLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGE 2167
Fly 3621 LI-----RSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDIL 3680
:: |:.:.::...:.|. |...:|..:|:|:...||.||||||.|:|||..:...:.
Mouse 2168 VVSEQEFRNRMIEQYHNHSDH-----YCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVN 2227
Fly 3681 GHKHIIIFALRRIVQGEELTYDYKF-PFEDEKIP-CSCGSKRCR 3722
|...|.::||:.:..|.||||||.| .|..||.. |.||.::||
Mouse 2228 GVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCR 2271
| 
