Protein Alignment trx and set-11

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_001364763.1
• Gene: set-11 / 185242
• WormBaseID: WBGene00018023
• Length: 278
• Species: Caenorhabditis elegans
• Alignment Length: 281
• Identity: 74/281 - (26%)
• Similarity: 105/281 - (37%)
• Gaps: 90/281 - (32%)

  Fly  3469 KYHKRNGNVSTAANGAHGGNLGGSSASAAL--------SVSGGDSHGLLDYGSDQDELEENAYDC 3525
            ||..|..:|:        |.|...|||...        |.:...|.|:...|...:.:|...:|.
 Worm    52 KYTSRIIDVA--------GQLACRSASPTFMCQCAGQCSTNCECSSGVFGEGGTVENMELLMWDT 108

  Fly  3526 AR-CEPYSNRSEYDMFSWLASRHRKQ----PIQVFVQPSDNELVPRRGTGSNLPMAMKYRTLKET 3585
            .| |..|.|.:     .|..:|..::    |:::|.
 Worm   109 VRECNEYCNCA-----LWCGNRVAQKGAMYPVEIFA----------------------------- 139

  Fly  3586 YKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERY--YDSRGIGCYMFKI-- 3646
                    |....|.|:..:.||..|..:.|||||||     |..|..  :||    .::|:.
 Worm   140 --------RDPWCGWGVRASVDIAFGTFIGEYAGELI-----DDEEAMDRHDS----TFLFETKV 187

  Fly  3647 -DDNLVVDATMRGNAARFINHCCEPNC--------YSKVVDILGHKHIIIFALRRIVQGEELTYD 3702
             .:.|.:||...||..|||||.|.||.        |.|:..|    |:..|..:.|.:|||||.|
 Worm   188 GSETLTIDAKYSGNYTRFINHSCAPNVKVANISWDYDKIQLI----HMCFFTDKAIRKGEELTID 248

  Fly  3703 Y-KFPFEDEKIPCSCGSKRCR 3722
            | :..:.::|.||.|.|..||
 Worm   249 YGEAWWANKKFPCLCKSSECR 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	3/6 (50%)
		SET_KMT2A_2B	3575..3726	CDD:380947	51/162 (31%)
set-11	NP_001364763.1	PreSET	21..117	CDD:128744	18/72 (25%)
		SET	75..270	CDD:394802	65/250 (26%)