DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and set-19

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	NP_001379854.1	Gene:	set-19 / 180834	WormBaseID:	WBGene00020919	Length:	953	Species:	Caenorhabditis elegans

Alignment Length:	837	Identity:	153/837 - (18%)
Similarity:	260/837 - (31%)	Gaps:	306/837 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KPSKSINRKRISVLQLEDDAANPAEPQQPAPESQQPSGSGSGSSAARE----------------- 56
            :.|:.|.|||..|             ::|.|||::...:...|..|.|
Worm   340 RTSRRIARKRAYV-------------REPTPESERCKRARDRSIIAAETIEAEIEEAHEKRMALK 391

  Fly    57 ------------KGN--NCDNDEDDNAPGGASISGNTASSSAGSGNSGNGSS--SGSSTGSGSSG 105
                        |.|  ..::.|:..:|..:|     :|||:|| ..||.||  |.|.....:..
Worm   392 ARKAFLLKRKLRKSNVRRTESPENKRSPVQSS-----SSSSSGS-TEGNVSSLRSRSDVRKSTRL 450

  Fly   106 SGSTNGGSVNGGTHHKSAANLDKEAVTKDQNGDGDKTRGNVSSAPSGKLSAAASGKALSKSSRTF 170
            .|..:..|::..|:|         |.::|   .|.:....|:....|:....:...|:|:|....
Worm   451 VGVRSSSSISVATNH---------AQSQD---PGFQPHSGVTRTLKGRFCRQSGRIAVSRSLLQL 503

  Fly   171 SASTSVTSSGRSSGSSPDGNSGASSDGASSGISCGKSTAKSTEASSGKL---AKTTGAGTC---- 228
            .|:.               ....|::|.:||:...:......|....:|   :|.:...||
Worm   504 RANK---------------RRQQSTEGDASGVRKNEGLVARKERERKELMLFSKRSRPQTCFMGV 553

  Fly   229 -SSAKSSKASSGTTSEATTSGLSGACLKALFVATPATSTGLACALVSPGGSSQGGTFPISAALLR 292
             ||.:.|..||.|:||...|        .....:|..|....     .|.|.|.......|:..|
Worm   554 KSSGRDSSMSSTTSSERERS--------PSLTESPVRSRNHV-----RGSSPQSSGLNERASRCR 605

  Fly   293 ARKNSNKKFKNLNLARGEVMLPSTS----KLKQLNSPVVDNPSPSPPIASGSTPSVEGGIGVGGV 353
            .|.....:.:. ..||..|.|.|.|    :::| .||.|.:|.......|.:.
Worm   606 ERVTRRTRLQT-TPARVPVELESVSPIPARVRQ-RSPEVQSPKSEMRTRSRAR------------ 656

  Fly   354 VSPGEDAALKRVLTEMPNEVARDPSPSSCTAAANGAASGKGSASNGP------PAMASSGDGSSP 412
             ..|.|....:..|....::..|.||....:.||....|.......|      |.:....||..|
Worm   657 -CDGYDVERDQSKTGDVVQIDVDGSPRITRSHANNHPMGHRKIQEKPIVEDAIPHLEPIIDGYHP 720

  Fly   413 KSGADTGPSTSSTTAKQKKTVTFRNVLETSDDKSVVKRFYNP-DIRIP---------IVSIMKKD 467
            :                      ||       :|||:....| |::||         .||.....
Worm   721 E----------------------RN-------ESVVRDVMEPLDVQIPQMNGEHHQTFVSPTSNK 756

  Fly   468 SLNRPLNYSRGGECIVRPSILSKILNKNSNIDKLNSLKFRSAGASSSSSNQESGSSSNVFGLSRA 532
            ||.|         |.:| |..|.:||                  |.:|::|||....:...|::.
Worm   757 SLRR---------CGLR-SDYSSVLN------------------SPASTSQESTGMRDTQRLNKV 793

  Fly   533 FGAPMDEDDEGGVTFRRND-----SPEDQNNAEDDEMDDDDDDEEAEEDDENEDDNDEAVSEKSA 592
                :.:::.|.:...|.:     ||....:...:.:|.|                  |.::...
Worm   794 ----LSKNNIGELESPRLNGTRVLSPPRTRHQISNAIDSD------------------AFNDMPV 836

  Fly   593 ETEKSAGADERDPDEKQLVMDSHFVLPKRSTRSSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNV 657
            .|:        :|.:::.::...|.:|:::|                                 .
Worm   837 LTQ--------EPVQERRMIAQVFEIPRKTT---------------------------------A 860

  Fly   658 FGTSSSSAGSTASTFSASTNLKLGKETFFNFGTLKPNSSAAGNFVLRQPRLQFQADNQQATFTAP 722
            :...|||.......|...:|..||   ||:                  |::.
Worm   861 YNQPSSSNSQQHGQFQVCSNGSLG---FFH------------------PQIY------------- 891

  Fly   723 KACPTSPSAIPKPA---NSLATSSFGSLASTNSSTVTPTPSACSICSAVVSSKEVTQ 776
            ::..|.|..:|...   ::|..||:.:....|:::....||         :|:::|:
Worm   892 QSMMTPPGIVPHAVISNSALGYSSYQAYIPNNNNSEQQYPS---------TSEDITR 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381	2/15 (13%)
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1891..1935	CDD:283589
		FYRC	3388..3476	CDD:197781
		SET	3590..3710	CDD:214614
set-19	NP_001379854.1	SET	175..322	CDD:214614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840