Protein Alignment trx and set-16

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_499819.3
• Gene: set-16 / 176802
• WormBaseID: WBGene00011729
• Length: 2475
• Species: Caenorhabditis elegans
• Alignment Length: 3407
• Identity: 638/3407 - (18%)
• Similarity: 1004/3407 - (29%)
• Gaps: 1390/3407 - (40%)

  Fly   762 CSICSAVVSSKEVTQARKYGVVACDVCRKFFSKMTKKSISANSSTANTSSGSQQYLQCKGNEGSP 826
            |..|..|         .:.|.::.|:.|:     ...|.|..|.....::.|:|...|:.:....
 Worm    17 CENCMDV---------NRSGTMSLDMARQ-----CDMSSSCGSCQRMITADSRQCTTCRKSYHLS 67

  Fly   827 CSIHSAKSQLKNFKKFYKDRCTACWLKKCMISFQLPAAHRSRLSAILPPGMRGEAAAREEKSAEL 891
            |. .|..|.|.||.      |.:|                .|.|.:||..:...|:||..:..:.
 Worm    68 CD-SSDVSSLNNFV------CISC----------------RRRSQMLPDDVMLSASARPSRGQDA 109

  Fly   892 -LSPTGSLRFTSTASSSSPSVVASTSVKWKSSGDSTSALTSIKPNPLAEN---NVTFGSTPLLRP 952
             |||           .|.|||              ......::|.||..:   :..|......:.
 Worm   110 PLSP-----------FSDPSV--------------PQISLQMQPAPLPSSYPRSQDFNGDVYTQI 149

  Fly   953 AILENPLFLKISNAADQKLAAAEAISPSLTKKNSKQEKEK------VKESEQSEKLLSPTQAGTK 1011
            |.::.....:..|...|.||....:...::......:.::      .:.|:..|..:..:..|..
 Worm   150 AAMQQQRQQQQQNQVQQMLATQAQLMDEISDGGGTNDSDRNSSPFYQEASDYDEDFVPASTRGRG 214

  Fly  1012 KSGAAEAQVEEVQPQKEEAPQTSTTTQPSASNGASHGVPQAELAG---------ETNAT------ 1061
            :.|.|:.     :|.:..:..|...|.|..|...|....|| ::|         :|::|
 Worm   215 RGGGAKK-----KPGRGGSTGTRRQTNPGPSGFFSATQLQA-MSGDFSHLHQPQQTSSTRGKRGK 273

  Fly  1062 ---GDTLKRQRIDLKGP---------------------RVKHVCRSASIVLGQPLATFGEDQQPE 1102
               |.::.||  ..|||                     :|::..:.|.:..|.|..   ...||.
 Worm   274 RGNGTSVPRQ--PGKGPGRGRGRGRGSAAAIAQLAQLQQVQYGAQGAPMFNGAPQL---HPTQPT 333

  Fly  1103 DAADMQQEI--------AAPVPSAIMEPSPEKPTHIVTDENDNCASCKTSPVGDESKPSKSSGSA 1159
            .|..:...:        |.|.|.|:..|.|:....||                    ||......
 Worm   334 VAPTLPPSVTYQNVAPTAPPAPPALQTPLPDPLPSIV--------------------PSFQQAPQ 378

  Fly  1160 QAEVKKATALGKEGTASAAGGSSAKVTTRNAAVASNLIVAASKKQRNGDIATSSSVTQSSNQTQG 1224
            ...:::...|..|                                           .:||.|:.|
 Worm   379 AVAIREVDELMLE-------------------------------------------DESSRQSGG 400

  Fly  1225 RKTKEHRQQRTLISIDFWENYDPAEVCQTGFGLIVTETVAQRA-LCFLCGSTGLDP---LIFCAC 1285
            .::.|....||.|            ||:      |.:...|:| :|.:|||.|..|   ::.|:.
 Worm   401 SRSDEPEYIRTAI------------VCR------VNDEFLQKACMCLVCGSIGKGPEGSMVACSN 447

  Fly  1286 CCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTC 1350
            |.:.||.|||              ||               ...||.......|.|..||||..|
 Worm   448 CAQTYHTYCV--------------TL---------------HDKLNSAVVGRGWRCLDCTVCEGC 483

  Fly  1351 NMSSGSKVK---CQKCQKNYHSTCLGTSKRLLGADR----PLICVNCLKCKSCSTTKVSKFVGN- 1407
            . :.|.:..   |.:|..:||..|:   |.||  |:    |..|..|.:|:.|:....|   ||
 Worm   484 G-TGGDEANLLLCDECDVSYHIYCM---KPLL--DKIPQGPWRCQWCSRCRRCNHKAAS---GND 539

  Fly  1408 ---LPMCTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGL-SDEQYNLLSTL 1468
               ..:|..|..|||    ||.|:|.|..|:   |::.|..|.:|.|..|||| :|||.
 Worm   540 LTSQGLCFPCASLRK----CPRCERNYQLNE---KLIRCSQCSKWQHGACEGLYTDEQL------ 591

  Fly  1469 PESIEFICKKCARRNESSKIKAEEWRQAVMEEFKASLYSVLKLLSKSRQACALLKLSPRKKLRCT 1533
                                     .||.::..:.|             ||
 Worm   592 -------------------------EQAAIDRMRCS-------------AC-------------- 604

  Fly  1534 CGASSNQGKLQPKALQFSSGSDNGLGSDGESQNSDDVYEFKDQQQQQQQRNANMNKPRVKSLPCS 1598
                      :||.:|.|..||                                    |.::.|
 Worm   605 ----------RPKRVQPSGFSD------------------------------------VDTVWC- 622

  Fly  1599 CQQHISHSQSFSLVDIKQKIAGNSYVSLAEFNYDMSQVIQQSNCDELDIAYKELLSEQFPWFQNE 1663
                                   .||:|   :.|..:::                         :
 Worm   623 -----------------------DYVAL---DKDAHEIL-------------------------K 636

  Fly  1664 TKACTDALEEDMFESC----SGGNYEDLQDTGGVSASVYNEHSTSQAESRSGVLDIPLEEVDDFG 1724
            :|....||:..|.||.    |..:|:|          .||                |||:..|
 Worm   637 SKYTPSALKNHMMESVGYRESFDHYDD----------DYN----------------PLEDSSD-- 673

  Fly  1725 SCGIKMRLDTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAV 1789
                            :.:...:.|:.
 Worm   674 ----------------QVTPLPIPGQR-------------------------------------- 684

  Fly  1790 ARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDCAFLTDKSMYCPAHAKNGNALKANGSP 1854
            .|||       ||.....|.|....|..|                 ...|.|.......:| .:.
 Worm   685 GRGR-------GNPSGRRGMNRIGIGGFY-----------------AKLPRHRIQALTEEA-AAA 724

  Fly  1855 SVTYESNFEVSRPVYVELDRKRKKLIE---PARVQ---FHIGSLEVRQLGAIVPRFSDSYEAVVP 1913
            :.:.|.:.:..||     .:.|:..:|   |.::|   |.|.::|.:.|          .:..|.
 Worm   725 AASSEDSKQAKRP-----RKSRRSQLEDAYPPQIQEAFFGIKAVEGKVL----------VDTPVD 774

  Fly  1914 INFLCSRLYWSSKEPWKIVEYTVRTTIQNSSSTLTALDVGRNYTVDHTNPNSKEVQLGMAQIARW 1978
            ..||.....|..:         .|:|                          |..:|.|......
 Worm   775 EPFLAEFNGWYKR---------TRST--------------------------KAFELCMTASEML 804

  Fly  1979 HTSLARSEFLENGGTDWSGEFPNPNSCVPPDENTEEEPQQQADLLPPELKDAIFEDLPHELLDGI 2043
            .|.:..:|||:..|.                      |..:.|.|         :|....||:.
 Worm   805 RTDIDENEFLDCVGL----------------------PNMETDAL---------DDFDFNLLED- 837

  Fly  2044 SMLDIFLYDDKTDLFAISEQSKDGTQAMTSNQAQNQNQQAGGANSVSICDEDTRNSNTSLGNGWP 2108
                 |..|::.|....|.....|...|..:.|:. .:.:.|..|.::   |.|.|.:|.|....
 Worm   838 -----FDVDEENDELENSLLGAPGNTEMKEDAAEG-IEGSYGPTSFNL---DQRPSTSSAGGSLG 893

  Fly  2109 ASNPVEDAMLSA-------------ARNSSQVQMLK----TLAWPKLDGNSAMATA--------- 2147
            :.:|....|..|             ||:.||....:    :..|.:.:.|...||.
 Worm   894 SQDPFHPGMNPANFAQHAPGVRNAIARSGSQTDNSERYQFSARWEEDEPNGLQATTAAVLYSNEK 958

  Fly  2148 --------------IKR-RKLSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSISET------- 2190
                          :|: :||.:.|...|.|...::.|:.:..:......||.::..|
 Worm   959 HGYLRQQFPNWVDRVKQIQKLWRTLNHEVRLDYVNRARDNRTRSGNRPRPRRTNVQSTDSPPPPQ 1023

  Fly  2191 -SVEGVATTSGSVRSKSFTWSAAKRYF-----------------------EKSEGREE------- 2224
             ..:..|..|.::...|......|:.|                       |:..|..|
 Worm  1024 MGFKVPANPSSNMMGSSEQSMQPKQVFITHHLPMDVYQVYQDLKRVKFDRERLNGSLEEQLNKAR 1088

  Fly  2225 ------AAKMRIM--------QMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDA 2275
                  |||.|.|        ..||.:..:.|    |....|:|  .:.|:|..:.:......|
 Worm  1089 KQKKNLAAKKRQMVKTQTAAPDYDGRNIDLNE----SDQQTLAT--LTEQIKVTQAEIELHRRD- 1146

  Fly  2276 FQRHLPSCSPTMSSNETESDVSG----QGMTNNATQISAESL--------------NELQKQLLA 2322
            .::|             ||::|.    .|:..|..::..|.:              :|:..|...
 Worm  1147 LKKH-------------ESNLSDFVMKHGILRNEHEVKREDVQLSAIRDQQYAAHADEMLAQQAQ 1198

  Fly  2323 NAGGLNYL--------QSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSLGSGFFLSQPNPATQAN 2379
            |. ||..:        |:|.|.|.:..    .|...|.:.|:|::....|.....:||....|.|
 Worm  1199 NQ-GLGQVHPPVLVAPQAAISLPMLNQ----QQQHHQRMMQMQMRGGPPGQFMMRAQPPQQPQIN 1258

  Fly  2380 TDDLQIYANSLQSLAAN----LGGGFTLAQPTVTAPAQPQLIAVSTNPDGTQQFIQIPQTMQATT 2440
            ..:.:|....|.....|    :||   :....:|.|....:
 Worm  1259 MHNHEIAKRMLMQQFRNAHPVMGG---IRHDEITDPIMRDV------------------------ 1296

  Fly  2441 TPTATYQTLQATNTDKKIMLPLTAAGKPLKTVATKAAQQAAVKQRQLKSGHQVKPIQAKLQPHPQ 2505
                 |..|:|...|             :.|||.:.|.|||        |.|..|      ||..
 Worm  1297 -----YDCLEAIVFD-------------VHTVAEREAMQAA--------GQQPPP------PHIM 1329

  Fly  2506 QHQQQQQTQVQQPITVMGQNLLQ----PQLLFQSSTQTQAPQIILPQAQ---PQNIISFVTGDGS 2563
            |...|     |.|....|..|:.    |||..:...| |.|.:.|||..   |:.......|.|:
 Worm  1330 QRMMQ-----QHPGGPGGPRLIMPGQFPQLQGRRIPQ-QPPPVQLPQVDVDPPKTAAKRKKGGGN 1388

  Fly  2564 QGQPLQYISIPTAGEY------------------KPQPQPTATPTFLTTAPGAGATYLQTDASGN 2610
            ..:...  |.|.||||                  |.|.:|.      ...||....
 Worm  1389 PKKNAS--SYPAAGEYDAWIEQMRMRFRLCPDIPKKQKEPR------LNRPGCEFV--------- 1436

  Fly  2611 LVLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILGGTGGGSSG 2675
                    :.||..:..::.:.:..::|..          ||...:.|:.    :.|....|...
 Worm  1437 --------SHGLTDMAVRATKKRTPLVGEF----------GAMRVKRGTR----LFGNEERGEKS 1479

  Fly  2676 LEFATTSPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQASKIEP 2740
            :.|                                                    |.....::||
 Worm  1480 IMF----------------------------------------------------QDLNLYQVEP 1492

  Fly  2741 IVDLPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQFQSVPTSS-------- 2797
            .:.|.|.|               .|....::.....|...||:..        |||:
 Worm  1493 QIRLFALY---------------NNPLPTMEDDVFRDEEDQIIDK--------PTSALQKLLNKK 1534

  Fly  2798 -GASTSMDY---TSPVMVTAKIPPVTQ--IKRTNAQAKAAGISGVGKVPPQPQVVNKVLPTSIVT 2856
             |||.:||:   .:..|....|||..:  :...|.:|:            :...|..|..|..:|
 Worm  1535 RGASGAMDHIRSRARYMEETNIPPAPERGMFYENVEAE------------EEVTVELVFNTCDIT 1587

  Fly  2857 QQSQVQVKNSNLKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNMIRPIHKLEVKPKV---MKP 2918
            ::|.|..|..                 .||           :....||.:  |.:|.:|   |:.
 Worm  1588 EESSVDEKKD-----------------VCG-----------RLHEQIRDL--LAIKDEVAWSMED 1622

  Fly  2919 TPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQMIHIPQQQ 2983
            ||              .:.|..:...|...|..|.: |.|..|.|::..::::::    .:.::.
 Worm  1623 TP--------------PESPVSRSPEPEATVGAVQQ-TSSTSRAPSEATEREIKR----EVEEEA 1668

  Fly  2984 QPLQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANRVQHFSTSSSSSSSNCSLPTNV 3048
            .|:                  ||.::.: ::||.              .:.:||...||
 Worm  1669 APV------------------APEIKRE-IVEPS--------------QSQNSSQCKNC------ 1694

  Fly  3049 VNPMQQQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNECPVVSSPTPP----------KPVEQPI 3103
                 |:|..:.||     |:.|....::...||..:.....::|.||          .|.|:..
 Worm  1695 -----QKALESHSS-----TSIVTVKAEKLNLAPTGSVVTTRAAPVPPGVPGAPGAPIAPSEEKT 1749

  Fly  3104 IHQMTSASVSKCYAQ-KSTLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPVTESIY------- 3160
            ..::.|....|||.: .|...:|:.|.|:..:                 ||.|:|.:|
 Worm  1750 KEELASFCSKKCYYELASATRAPLTEEEVAAA-----------------EQHVSEEVYNKLKQVL 1797

  Fly  3161 TEGLYEKNSPGESKTEQL--------LLQQQQREQLNQQLVNNGYLLDKHTFQVE-PMDTDVYRE 3216
            ||.:.:..|.|:....||        ::.:.:||  |..:|....|:.    .|| |.:....|.
 Worm  1798 TENIVKAVSQGKKPDPQLTSPRDTRCMMDEGRRE--NVTIVPVASLIG----AVEAPKEAPSQRA 1856

  Fly  3217 EDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKI--------LDNLTNDDC---ADS 3270
            .:..|:        .|..|.:..|..::..::.|......||        ||......|   .|.
 Worm  1857 AEAAED--------WKAYTKSIWDSFVNIQQQHAHHILSPKIGVPHPPYHLDKRICVFCGGIGDG 1913

  Fly  3271 IATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFE---GAL---ETAAVEAAAT--------- 3320
            ..|.....:..:..|.     |....|..||  |.||   |.|   :.|.:.||.|
 Worm  1914 ETTRCGRLISLTEFYW-----VHVNCALWSA--EVFENQTGGLTNVDRAVLRAAQTACDHCKRPG 1971

  Fly  3321 ------YINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIV------------- 3366
                  .:|...:.|||...| .||..:     |:......|.::.|..|||
 Worm  1972 ASVKCHKMNCGVNYHVLCAMQ-NNGFFI-----KDRTFICKQHEKVSNQAIVGRLDALRRIYVKR 2030

  Fly  3367 ---------------PT--------------AAAPEP-----------PQPIQEPKKMTGP---- 3387
                           ||              :..|:.           |...:..:....|
 Worm  2031 DENTMLTRLFELTDGPTLCMRLGAFTFYKIGSITPKQLKRFHTKDYIFPNNYRITRLFWSPKSHR 2095

  Fly  3388 -HLLYEIQSED---------------GFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLAD 3436
             .:::|...||               ...||:.|.::.|:.::|.|      |.|....:|....
 Worm  2096 ERMMFECIIEDRNNQPIFVVKSLEDPTICYKAVSASKAWQPIYEKV------HQLREQQQGDSLK 2154

  Fly  3437 MGGIQ-----MIGLKTNALKYLIEQLPGVEK------------------------CSKYTPK--- 3469
            ..|.|     :.||..||:..:.|.|||.:.                        |::..|:
 Worm  2155 FFGSQICGETLFGLNENAITKITESLPGFDTIFTYQHRHQNSPVLELPLAENLMGCARAEPRNRT 2219

  Fly  3470 --YHKRNGNVSTAANGAHGGNLGGSSASAAL----------------------SVSGGDSHGLLD 3510
              .|.|...........|.|:..|.|:.|.:                      |.:.|.:.|:..
 Worm  2220 IGQHFRTKPQPMGGTHHHIGSASGLSSQATIIASSSSSANESLQSRQAATSVTSANSGRTRGVRS 2284

  Fly  3511 YGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRRGTGSNLPM 3575
            |.:::......|:.                               :.|....|..|..|..|...
 Worm  2285 YYTEEAAARARAFG-------------------------------IPPEMASLSLRMETTQNAQT 2318

  Fly  3576 AMK-YRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGI 3639
            |.. |:.::..:||.|.:.||.|.|.|||...||..|:.:|||.||:|||.:.:.||..|.::..
 Worm  2319 AFSAYQKMRREWKDRVYLARSRIAGLGLYAKVDISMGDFIIEYKGEIIRSEVCEVREIRYVAQNR 2383

  Fly  3640 GCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDI---LGHKHIIIFALRRIVQGEELTY 3701
            |.|||:||:..|:||||.|..||:|||.|:|||.::::|.   ...|.|||.|.|.|...|||||
 Worm  2384 GVYMFRIDEEWVIDATMAGGPARYINHSCDPNCSTQILDAGSGAREKKIIITANRPISANEELTY 2448

  Fly  3702 DYKFPFE--DEKIPCSCGSKRCRKYLN 3726
            ||:|..|  .:||||.||:..|.|::|
 Worm  2449 DYQFELEGTTDKIPCLCGAPNCVKWMN 2475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390	20/93 (22%)
		PRK13914	<1006..>1224	CDD:237555	42/264 (16%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	19/78 (24%)
		PHD	1346..1390	CDD:214584	15/50 (30%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	18/56 (32%)
		ePHD_KMT2A_like	1737..1841	CDD:277134	11/103 (11%)
		FYRN	1890..1937	CDD:461787	6/46 (13%)
		FYRC	3388..3476	CDD:197781	26/136 (19%)
		SET_KMT2A_2B	3575..3726	CDD:380947	72/156 (46%)
set-16	NP_499819.3	PHD_SF	42..84	CDD:276966	12/48 (25%)
		PHD4_KMT2C_like	427..477	CDD:276987	19/78 (24%)
		PHD5_KMT2C_like	479..524	CDD:276988	15/50 (30%)
		PHD6_KMT2C_like	554..604	CDD:276989	22/100 (22%)
		HMG_KMT2C-like	936..1002	CDD:438813	11/65 (17%)
		ePHD2_KMT2C_like	1904..2008	CDD:277136	25/116 (22%)
		FYRN	2053..2104	CDD:461787	4/50 (8%)
		FYRC	2112..2199	CDD:197781	19/92 (21%)
		SET_KMT2C_2D	2319..2474	CDD:380948	72/154 (47%)