Protein Alignment trx and Ezh2

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_001396739.1
• Gene: Ezh2 / 14056
• MGIID: 107940
• Length: 751
• Species: Mus musculus
• Alignment Length: 920
• Identity: 168/920 - (18%)
• Similarity: 287/920 - (31%)
• Gaps: 277/920 - (30%)

  Fly  2881 TGTTCGAPPSIASKPLQKKTNMIRPIHKL----EVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQ 2941
            ||......|....|.::.:...:|.:.:.    |||........|:..:..:|.|:.:|::.|
Mouse     4 TGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQ-- 66

  Fly  2942 QQIPAVVVNQVPKV-------TISQQRIPAQT-QQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMP 2998
               |..::..|..:       ..|....|||. ..:.|.....:.|.....||||.
Mouse    67 ---PVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQN--------- 119

  Fly  2999 IITLAEAPVVQSQFVMEPQALEQQ------------------------------ELANRVQHFST 3033
             ..:.:..|:.:...|..:.|:|.                              ||.|.:..::.
Mouse   120 -FMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYND 183

  Fly  3034 SSSSSSSN---------------------C---SLPTN-VVNPMQQQAPSTTSSSTTRPTNRVLP 3073
            .......:                     |   ..|.: :...:....|...::...:...:.|.
Mouse   184 DDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELT 248

  Fly  3074 MQQRQEPAPLSNEC-PVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVYEAEL-KVSSV 3136
            .||.  |..|..|| |.:..|.......:..:|...:....:|:.         |:..| :..|.
Mouse   249 EQQL--PGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFK---------YDCFLHRKCSY 302

  Fly  3137 LESIVPDV----TMDAILEEQPVTESIY--TEGLYEKNSPGESKTEQLLLQQQQRE--QLNQQLV 3193
            .....|:.    ..:..|:.:|.....|  .||..|.   ..:.|.:.:....:|.  :...:|.
Mouse   303 SFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEF---AAALTAERIKTPPKRPGGRRRGRLP 364

  Fly  3194 NNGYLLDKHTFQV-EPMDTDVYRE---------EDLEEEEDEDDDFSLKMATSACNDH-EMSDSE 3247
            ||.......|..| |..|||..||         .|.||||.:|:..|...|.|.|... :|..:.
Mouse   365 NNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNI 429

  Fly  3248 EPAVKDKISKILDNLTNDDCADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALET 3312
            ||.         :|                 |:.|.....|...::.|
Mouse   430 EPP---------EN-----------------VEWSGAEASMFRVLIGT----------------- 451

  Fly  3313 AAVEAAATYINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQP 3377
                   .|.|..|.|.::..|..:...|..::             |.|..|.|||.....||:.
Mouse   452 -------YYDNFCAIARLIGTKTCRQVYEFRVK-------------ESSIIAPVPTEDVDTPPRK 496

  Fly  3378 IQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQM 3442
            .:...::...| ..:||.:     |..|...::
Mouse   497 KKRKHRLWAAH-CRKIQLK-----KDGSSNHVY-------------------------------- 523

  Fly  3443 IGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHG 3507
                                  .|.|..|.|.                ...:|....::......
Mouse   524 ----------------------NYQPCDHPRQ----------------PCDSSCPCVIAQNFCEK 550

  Fly  3508 LLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRRGTGSN 3572
            .....|:.    :|.:...||:...|.             ::.|..:.|:..|.:|....|...:
Mouse   551 FCQCSSEC----QNRFPGCRCKAQCNT-------------KQCPCYLAVRECDPDLCLTCGAADH 598

  Fly  3573 LP---MAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYY 3634
            ..   ::.|..:::...|.::.:..|.:.|.|::....::..|.:.||.||:|.....|:|.:.|
Mouse   599 WDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY 663

  Fly  3635 DSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEEL 3699
            | :.:..::|.::::.|||||.:||..||.||...||||:||:.:.|...|.|||.|.|..||||
Mouse   664 D-KYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEEL 727

  Fly  3700 TYDYKFPFED 3709
            .:||::...|
Mouse   728 FFDYRYSQAD 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	9/87 (10%)
		SET_KMT2A_2B	3575..3726	CDD:380947	47/135 (35%)
Ezh2	NP_001396739.1	Interaction with EED	39..68		6/33 (18%)
		EZH2_WD-Binding	39..68	CDD:463308	6/33 (18%)
		PRC2_HTH_1	158..249	CDD:436286	7/90 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	180..217		1/36 (3%)
		Interaction with CDYL. /evidence=ECO:0000250	334..527		54/318 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	345..431		23/85 (27%)
		preSET_CXC	564..595	CDD:408079	7/43 (16%)
		SET_EZH2	614..733	CDD:380995	45/119 (38%)