Protein Alignment trx and LOC1273034

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: XP_061503806.1
• Gene: LOC1273034 / 1273034
• VectorBaseID: AGAMI1_009472
• Length: 865
• Species: Anopheles gambiae
• Alignment Length: 1060
• Identity: 190/1060 - (17%)
• Similarity: 322/1060 - (30%)
• Gaps: 373/1060 - (35%)

  Fly  1735 RMCLFCRKSGEGLSGEEARLLYCG--HDCW---VHTNCAMWSAEVFEE-------IDGSL-QNVH 1786
            ::|..|:      |.|:..||: |  :..|   ||..|.:.|:.:.:.       |.|.| |::.
Mosquito     3 KVCFLCK------SSEDDELLF-GKFYTKWRLSVHYYCLLLSSNLVQNGVNDTVGIFGFLEQDIR 60

  Fly  1787 SAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDC-AFLTDK-SMYCPAHAKNGNALK 1849
            ....|.:..:|.:|....|.|.|..:.|...:|..|.....| :..||. ..:|.:|
Mosquito    61 KENERTKKCRCYICKEMHANVSCCSKKCLRTFHTVCGIKNRCLSHYTDTFQSWCASH-------- 117

  Fly  1850 ANGSPSVTYESNFEVSRPVYVELDRKRKKLIEPARVQFHIGSLEVRQLGAIVPRFSDSYEAVVPI 1914
                              :.||.|.:.....||..:.:.       ::|        .|:.:..|
Mosquito   118 ------------------IPVERDAQPHTAEEPCSICYD-------EMG--------QYDRITSI 149

  Fly  1915 NFLCSRLYWSSKEPWKIVEYTVRTTIQNSSSTLTALDVGRNYTVDHTNPNSKEVQLGMAQIARWH 1979
            ...|.|..|          :..|...|.:.|.        .|.......|:::..|  .:|.|
Mosquito   150 RAPCCRNGW----------FHQRCVAQYAQSA--------GYFFKCPLCNNEDTFL--PEIPR-- 192

  Fly  1980 TSLARSEFLENGGTDWSGEFPN--------PNSCVPPDENTEEE--------------------P 2016
                |..|:......|..| ||        |.:|...|...|:.                    .
Mosquito   193 ----RGVFVPERDAAWELE-PNAFQEQLVRPTACDSEDCKCEQGRSVDSHEWRLVICGSCGSTCR 252

  Fly  2017 QQQADLLPPELKDAIFEDLPHELL-DGISMLDIFLYDDKTDLFAISEQSKDGTQAMTSNQAQNQN 2080
            .:|.....|||..|....|...:| :.:|     |.:|..|     :.|:|.|.|..|:.:.:|.
Mosquito   253 HRQCMEATPELTRAYVCQLCRPILGERVS-----LVEDSDD-----DSSEDETVASGSSSSASQF 307

  Fly  2081 QQAGGANSVSICDEDTRNSNTSLGNGWPASNPVEDAMLSAARNSSQVQMLKTLAWPKLDGNSAMA 2145
            .:...|..:|     ...|..|   |...|:..::|:::..|.:.  :.:.|:|....|...:.|
Mosquito   308 DKVRPAKELS-----RPGSGES---GVHCSSSSDEALVAVCRRAR--RNVATIASDGSDSEHSDA 362

  Fly  2146 TAIKRRKLSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSISETSVEGVATTSGSVRSKSFTWS 2210
            ::::.|:.             .||...|.:        |:.:|:.|.||.:...|
Mosquito   363 SSVQLRRF-------------VQQNTGKRV--------RRLLSDESDEGTSNPMG---------- 396

  Fly  2211 AAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDA 2275
                                ::.||.|.|..        |.||.:..|..:|.|
Mosquito   397 --------------------VEEDGKDPSEA--------GQLSKSGTSKHLKTD----------- 422

  Fly  2276 FQRHLPSCSPTMSSNETESDVSGQGMTNNATQISAESLNELQKQLLANAGGLNYLQSATSFPQVQ 2340
                   ..|| |:.....|.|..|.....:.:                       ||...|.|.
Mosquito   423 -------TKPT-SALALSVDRSPAGRVYETSGV-----------------------SAAPHPDVV 456

  Fly  2341 SLGSLGQ--FGLQGLQQLQLQPQSLGSGF-----FLSQPNPATQANTDDLQIYANSL--QSLAAN 2396
            |:.|..:  .|::..::...:.:||.:..     ..|:.......:.|||.:   |:  |.:..|
Mosquito   457 SIDSTSESSIGIRKPKRANGRRRSLSTSSDDTHDTRSEDGSHVSEDLDDLPL---SIFRQKMRGN 518

  Fly  2397 LGGGFTLAQPTVTAPAQ----PQLIAVSTNPDGTQQF-----IQIPQTMQATTTPTATYQTLQAT 2452
                       .|.|.|    |.....|..|:.|.:.     ...|:..:.|....|      ::
Mosquito   519 -----------KTKPLQKLYKPSRRRSSLGPERTTKLSVDTGCNKPEDAKHTNHSNA------SS 566

  Fly  2453 NTDKKIMLPLTAAGKPLKTVATKAAQQAAVKQRQL-KSGHQVKPIQAKLQPHPQQHQQQQQTQVQ 2516
            |.|..        |:..:.::.:.:...|.|||.. :|..::.|.:..:...|:.....:|::.|
Mosquito   567 NNDDD--------GRRTRQLSRRLSLNDAGKQRSTSESSSEILPRKRAIARRPRLDSSSEQSEKQ 623

  Fly  2517 QPI---TVMGQNLLQPQLLFQSSTQTQAPQIILPQAQPQNIISFVTGDGSQGQPLQYISIPTAGE 2578
            ..:   |...:.....:.......|...|:||.|.:.|.::.|..|...|.
Mosquito   624 AAVPDETTSSKAPRSKRRRLSREQQRHRPRIISPPSTPPSLASETTSQQSD-------------- 674

  Fly  2579 YKPQPQPTATPTFLTTAPGAGATYLQTDASGNLVLTTTPSNSGLQMLTAQSLQAQPQVIGT---- 2639
                               .|:|....|||.:|..||||        |:.|....|..:|:
Mosquito   675 -------------------TGSTTGGADASEDLKHTTTP--------TSSSSHPTPASVGSTPNR 712

  Fly  2640 ------------------------------LIQPQTIQLGGGADGNQPGSNQQPLILGGT---GG 2671
                                          .|.|..::..||:..:.||..:     .||   |.
Mosquito   713 QQHQQSILKFVNCSARKTTPASRSDGSTEETISPPRMKQTGGSGSSDPGKAE-----SGTKKQGS 772

  Fly  2672 GSSGLEFATTSPQVILATQP 2691
            .:.|.:.|....:...||.|
Mosquito   773 PAEGGKRAIAVKRTRSATDP 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134	29/118 (25%)
		FYRN	1890..1937	CDD:461787	6/46 (13%)
		FYRC	3388..3476	CDD:197781
		SET_KMT2A_2B	3575..3726	CDD:380947
LOC1273034	XP_061503806.1	None