DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trx and Ehmt2

DIOPT Version :10

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:NP_001390796.1 Gene:Ehmt2 / 110147 MGIID:2148922 Length:1394 Species:Mus musculus


Alignment Length:1638 Identity:304/1638 - (18%)
Similarity:486/1638 - (29%) Gaps:615/1638 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 AEPQQPAPESQQPSGS-GSGSSAAREKGNNCDNDEDDNAPGGASISGNTASSSAGSGNSGNGSSS 95
            ||...|.|.:  |:.: |:.:..||.:|..       ..|.|...:|  .:...|.|..|.|...
Mouse    39 AESHVPPPAA--PAWAVGTATPGARARGAR-------GRPPGWGAAG--VAGVGGRGPRGLGDKG 92

  Fly    96 GSSTGSGSSGSGSTNGGSVNGGTHHKSAANLDKEAVTKDQNGDGDKTRGNVSSAPSGKLSAAASG 160
            |::..:|..|.|                                   ||..:..|...|..|...
Mouse    93 GAARAAGRRGRG-----------------------------------RGAEAPPPPPPLLPAPEM 122

  Fly   161 KALSKSSRTFSASTSVTSSGRSSG-SSPDGNSGASSDGASSGISCGKSTAKSTEASSGKLAKTTG 224
            :.|.:......|        |..| ::|.|..|....||.                       .|
Mouse   123 RGLPRGRGLMRA--------RGRGRAAPTGGRGRGRGGAH-----------------------RG 156

  Fly   225 AGTCSSAKSSKASSGTTSEATTSGLSGACLKALFVATPATSTGLACALVSPGGSSQGGTFPISAA 289
            .|...|..|...:..:.:....:||:|..:..|                    .|||.. |....
Mouse   157 RGRPRSLLSLPRAQASWAPQLPAGLTGPPVPCL--------------------PSQGEA-PAEMG 200

  Fly   290 LLRARKNSNKKFKNLNLARG-----EVMLPSTSKLKQLNSPVVDNPSPSPPIASGSTPSVEGGIG 349
            .|...|......:.::.:.|     |..||..            ||....|....|..||...:|
Mouse   201 ALLLEKEPRGAAERVHSSLGDTPQSEETLPKA------------NPDSLEPAGPSSPASVTVTVG 253

  Fly   350 VGGVVSPGEDAALKRVLTEMPNEVARD--------------PSPS---SCTAAANGAASGKGSAS 397
            ..|..:|...|:|   :.:.|..:..|              .|||   :|.:.|..:.:|.|.: 
Mouse   254 DEGADTPVGAASL---IGDEPESLEGDGGRIVLGHATKSFPSSPSKGGACPSRAKMSMTGAGKS- 314

  Fly   398 NGPPAMAS--------SGDGSSPKSGADTGPSTSSTTAKQKKTVTFRNVL-ETSDDKSVVKRFYN 453
              ||::.|        .|...:..:|.:..|:|::....|.|....|..: :.|:.:..:     
Mouse   315 --PPSVQSLAMRLLSMPGAQGAATAGPEPSPATTAAQEGQPKVHRARKTMSKPSNGQPPI----- 372

  Fly   454 PDIRIPIVSIMK-KDSLNRPLNYSRGGECIVRPSILSKILNKNSNIDKLNSLKFRSAGASSSSSN 517
            |:.|.|.|...: .|.::                 |.|:.:..:...||||       .|.|...
Mouse   373 PEKRPPEVQHFRMSDDMH-----------------LGKVTSDVAKRRKLNS-------GSLSEDL 413

  Fly   518 QESGSSSNVFGLSRAFGAPMDE------DD-----EGGVTFRRNDSPE--------DQNNAEDDE 563
            ..:|.|.::. |.:....|::|      ||     :......|.||..        :|.:.|::|
Mouse   414 GSAGGSGDII-LEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVDSDSKSEVEALAEQLSEEEEE 477

  Fly   564 MDDDDDDEEAEEDDENEDDNDEAVSEKSAETEKSAGADERDPDEKQLVMDSHFVLPKRSTRSSRI 628
            .::::::||.||::|.|::.||   |...::::| |:..|...:|:...||.:|.|.|..|.   
Mouse   478 EEEEEEEEEEEEEEEEEEEEDE---ESGNQSDRS-GSSGRRKAKKKWRKDSPWVKPSRKRRK--- 535

  Fly   629 IKPNKRLLEEGAISTKKPLSLGDSKGKNVFGTSSSSAGSTASTFSASTNLKLGKETFFNFGTLKP 693
                           ::|....:.:|.|..|:|..         |....:.||.....:.|||.|
Mouse   536 ---------------REPPRAKEPRGVNGVGSSGP---------SEYMEVPLGSLELPSEGTLSP 576

  Fly   694 NSSAAGNFV--LRQPRLQFQADNQQATFTAPKACPTSPSAIPKPANSLATSSF-GSLASTNSSTV 755
            |.:...|..  |...|...:.........|||....|..|..|   .:||.|. |.|..      
Mouse   577 NHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHK---CMATESVDGELLG------ 632

  Fly   756 TPTPSACSICSAVVSSKEVTQ--ARKYGVVACDVCRKFFSKMTKKSISANSSTANTSSGSQQYLQ 818
                     |:|.:..:|..:  :|...:|.|:..|   ::|.|...                  
Mouse   633 ---------CNAAILKRETMRPSSRVALMVLCEAHR---ARMVKHHC------------------ 667

  Fly   819 CKGNEGSPCSIHSAKSQLKNFKKFYKDRCTACWLKKCMISFQLPAAHR------SRLSAILPPGM 877
            |.|     |...                |||....:|...|::  |||      |:|:.::....
Mouse   668 CPG-----CGYF----------------CTAGTFLECHPDFRV--AHRFHKACVSQLNGMVFCPH 709

  Fly   878 RGEAAAREEKSAELLSPTGSLRFTSTASSSSPSVVASTSVKWKSSGDSTSALTSIKPNPLAENNV 942
            .||.|:   ::.|:..|.|.                                             
Mouse   710 CGEDAS---EAQEVTIPRGD--------------------------------------------- 726

  Fly   943 TFGSTPLLRPAILENPLFLKISNAADQKLAAAEAISPSLTKKNSKQEKEKVKESEQSEKLLSPTQ 1007
              |.||             .|..||           |:|                          
Mouse   727 --GGTP-------------PIGTAA-----------PAL-------------------------- 739

  Fly  1008 AGTKKSGAAEAQVEEVQPQKEEAPQTSTTTQPSASNGASHGVPQAELAGETNATGDTLKRQRIDL 1072
                            .|...:||..:.|:|||| ....||.|:..   ..:...||     ||.
Mouse   740 ----------------PPLAHDAPGRADTSQPSA-RMRGHGEPRRP---PCDPLADT-----IDS 779

  Fly  1073 KGPRVKHVCRSASIVLGQPLATFGEDQQP-----EDAADMQQEIAAPVPSAIMEPSPEKPTHIVT 1132
            .||       |.::..|..|:..|....|     |.|..:|:..:.|.|    .|||::...:..
Mouse   780 SGP-------SLTLPNGGCLSAVGLPPGPGREALEKALVIQESESPPSP----PPSPDRRKKLRF 833

  Fly  1133 DENDNCASCKTSPV-----------------GDESKPSKSSGSAQ-AEVKKATALGKEGTASAAG 1179
            .......|.|...:                 ..:||.:....:|| ..|:....|.:.|....|.
Mouse   834 HPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAV 898

  Fly  1180 GSSAKVTTRNAAVASNLIVAASKKQRNGDIATSSSVTQSSNQTQGRKTKEHRQQ-------RTLI 1237
            ....:.....|.|.::|.||....|..|.:        .|.:..|.....|..:       ..|:
Mouse   899 DKQQRTPLMEAVVNNHLEVARYMVQLGGCV--------YSKEEDGSTCLHHAAKIGNLEMVSLLL 955

  Fly  1238 S---ID------------FW----ENYDPAEVCQTGFGLIVTETVAQRALCF----LCGSTGLDP 1279
            |   :|            .|    ::.|...:..|. |..||.|..:..:|.    ..||..:..
Mouse   956 STGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTR-GADVTLTDNEENICLHWASFTGSAAIAE 1019

  Fly  1280 LIFCACCCEPYHQYCVQDEYNLKHG----------SFEDTTLMGSLLETTVNASTGPSSSLNQLT 1334
            ::..|.|......|         ||          |:.|..|:        ..|.|.:..|....
Mouse  1020 VLLNAQCDLHAVNY---------HGDTPLHIAARESYHDCVLL--------FLSRGANPELRNKE 1067

  Fly  1335 QRLNW-LCP-RCTVCYTCNMS------------SGSKVKCQKCQKNYHSTCLGTSKRLLGADRPL 1385
            ....| |.| |..|.:...::            ...|:.|:...:.|.:.             |:
Mouse  1068 GDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICRDVARGYENV-------------PI 1119

  Fly  1386 ICVNCLKCKSC-------------STTKVSKFVGNLPMCTGCFKLRKKGNFCPICQRCYDDNDFD 1437
            .|||.:..:.|             ||..:.:.:.:|..||                 |.||    
Mouse  1120 PCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCT-----------------CVDD---- 1163

  Fly  1438 LKMMECGD----CGQWVHSKC----EGLSDEQYNLLSTLPESIEFIC-------KKCARRNESS- 1486
                 |..    ||| :..:|    :|...:::|.:.  |..| |.|       :.|..|...| 
Mouse  1164 -----CSSSNCLCGQ-LSIRCWYDKDGRLLQEFNKIE--PPLI-FECNQACSCWRSCKNRVVQSG 1219

  Fly  1487 -KIKAEEWRQAVM 1498
             |::.:.:|.|.|
Mouse  1220 IKVRLQLYRTAKM 1232

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:413390 15/95 (16%)
PRK13914 <1006..>1224 CDD:237555 48/240 (20%)
PHD1_KMT2A_like 1268..1344 CDD:276981 17/91 (19%)
PHD 1346..1390 CDD:214584 7/55 (13%)
PHD3_KMT2A_like 1423..1479 CDD:276983 14/70 (20%)
ePHD_KMT2A_like 1737..1841 CDD:277134
FYRN 1890..1937 CDD:461787
FYRC 3388..3476 CDD:197781
SET_KMT2A_2B 3575..3726 CDD:380947
Ehmt2NP_001390796.1 PHA03247 <126..379 CDD:223021 59/327 (18%)
EHMT_ZBD 594..723 CDD:411018 37/193 (19%)
ANKYR 838..1071 CDD:440430 44/258 (17%)
ANK repeat 870..899 CDD:293786 6/28 (21%)
ANK repeat 934..966 CDD:293786 5/31 (16%)
ANK repeat 969..999 CDD:293786 6/30 (20%)
ANK repeat 1001..1032 CDD:293786 5/30 (17%)
ANK repeat 1034..1065 CDD:293786 8/38 (21%)
SET_EHMT2 1132..1370 CDD:380931 26/131 (20%)
Blue background indicates that the domain is not in the aligned region.

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