Protein Alignment trx and EHMT2

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: XP_006715037.2
• Gene: EHMT2 / 10919
• HGNCID: 14129
• Length: 1395
• Species: Homo sapiens
• Alignment Length: 1575
• Identity: 307/1575 - (19%)
• Similarity: 500/1575 - (31%)
• Gaps: 493/1575 - (31%)

  Fly    32 AEPQQP-APESQQPSGSGSGSSAAREKGNNCDNDEDDNAPG-GASISGNTASSSAGSGNSGNGSS 94
            |..|.| |||    ..:|:|:..||.:|..      ...|| ||:.:|...:    .|..|.|..
Human    41 ARVQPPAAPE----WATGAGAPGARVRGTR------GRPPGWGAAGAGGVGA----RGPRGLGDK 91

  Fly    95 SGSSTGSGSSGSGSTNGGSVNGGTHHKSAAN-------LDKEAVTKDQNGDG-DKTRGNVSSAPS 151
            .|::..:|..|.|             :.|..       |....:.....|.| .:.||...:||.
Human    92 GGAARAAGRRGRG-------------RGAEAPPPPPPLLSAPEMRGLPRGRGLMRARGRGRAAPP 143

  Fly   152 GKLSAAASG--------KALSKSSRTFSASTSVTSSGRSSGSSPDGNSGASSDGASSGISCGKST 208
            |.......|        ::|....|..::.|...|:|.:|...|...|...:......:...|.|
Human   144 GSRGRGRGGPHRGRGRPRSLLSLPRAQASWTPQLSTGLTSPPVPCLPSQGEAPAEMGALLLEKET 208

  Fly   209 AKSTEASSGKLAKTTGAGTCSSAKSSKASSGTTSEATTSGLSGACLKALFVATPATSTGLACALV 273
            ..:||...|.|..|            ..|..|..:||...|.           ||..:..|...|
Human   209 RGATERVHGSLGDT------------PRSEETLPKATPDSLE-----------PAGPSSPASVTV 250

  Fly   274 SPGGSSQGGTFPISAALLRARKNSNKKFKNLNLARGEVMLPSTSKLKQLNSPVVDNPSPSPPIAS 338
            :.|  .:|...|:.|..|...::.|.:... :|..|.::|...:|           ..||.|...
Human   251 TVG--DEGADTPVGATPLIGDESENLEGDG-DLRGGRILLGHATK-----------SFPSSPSKG 301

  Fly   339 GSTPSVEGGIGVGGVVSPGEDAALKRVLTEMPNEVARDPSPSSCTAAANGAASGKGSASNGPPAM 403
            ||.||.......|...||....:|...|..||                  .|.|..:|.:.||..
Human   302 GSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMP------------------GAQGAAAAGSEPPPA 348

  Fly   404 ASSGDG-----------SSPKSGADTGPSTSSTTAKQKKTVTFRNVLETSDDKSVVKRFYNPDIR 457
            .:|.:|           |.|.:|....|        :|:....::...:.|..|:.|
Human   349 TTSPEGQPKVHRARKTMSKPGNGQPPVP--------EKRPPEIQHFRMSDDVHSLGK-------- 397

  Fly   458 IPIVSIMKKDSLNRPLNYSRGGECIVRPSILSKILNKNSNIDKLNSLKFRSAGASSSSSNQES-- 520
              :.|.:.|   .|.|| |.||        ||:.|.......::...|    |...|....|:
Human   398 --VTSDLAK---RRKLN-SGGG--------LSEELGSARRSGEVTLTK----GDPGSLEEWETVV 444

  Fly   521 GSSSNVFGLSRAFGAPMDEDDEGGVTFRRNDSPEDQNNAEDDEMDDDDDDEEAEEDDENEDDNDE 585
            |...:::..|.:....:|.|.:..|     ::..:|.:.|::|.::::::||.||::|.|::::|
Human   445 GDDFSLYYDSYSVDERVDSDSKSEV-----EALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEE 504

  Fly   586 AVSEKSAETEKSAGADERDPDEKQLVMDSHFVLPKRSTRSSRIIKPNKRLLEEGAISTKKPLSLG 650
                 |......:|:..|...:|:...||.:|.|.|..|.                  ::|....
Human   505 -----SGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRK------------------REPPRAK 546

  Fly   651 DSKGKNVFGTSSSSAGSTASTFSASTNLKLGKETFFNFGTLKPNSSAAGNFV--LRQPRLQFQAD 713
            :.:|.|..|:|..         |....:.||.....:.|||.||.:...|..  |...|...:..
Human   547 EPRGVNGVGSSGP---------SEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELP 602

  Fly   714 NQQATFTAPKACPTSPSAIPKPANSLATSSF-GSLASTNSSTVTPTPSACSICSAVVSSKEVTQ- 776
            .......|||....|..|..|   .:||.|. |.|:.               |:|.:..:|..:
Human   603 LCSCRMEAPKIDRISERAGHK---CMATESVDGELSG---------------CNAAILKRETMRP 649

  Fly   777 -ARKYGVVACDVCRKFFSKMTKKSISANSSTANTSSGSQQYLQCKGNEGSPCSIHSAKSQLKNFK 840
             :|...:|.|:..|   ::|.|...                  |.|     |...
Human   650 SSRVALMVLCETHR---ARMVKHHC------------------CPG-----CGYF---------- 678

  Fly   841 KFYKDRCTACWLKKCMISFQLPAAHR------SRLSAILPPGMRGEAAAREEKSAELLSPTGSLR 899
                  |||....:|...|::  |||      |:|:.::.....||.|:   ::.|:..|.|. .
Human   679 ------CTAGTFLECHPDFRV--AHRFHKACVSQLNGMVFCPHCGEDAS---EAQEVTIPRGD-G 731

  Fly   900 FTSTASSSSPSVVASTSVKWKSSGDSTSALTSIKPNPLAEN--NVTFGSTPLLRPAILENPLFLK 962
            .|..|.:::|:                       |.||:::  .....|.|..|......|....
Human   732 VTPPAGTAAPA-----------------------PPPLSQDVPGRADTSQPSARMRGHGEPRRPP 773

  Fly   963 ISNAADQKLAAAEAISPSLTKKN-------------SKQEKEK---VKESEQSEKL-LSPTQAG- 1009
            ....||    ..::..||||..|             .::..||   ::|||:.:|| ..|.|..
Human   774 CDPLAD----TIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQESERRKKLRFHPRQLYL 834

  Fly  1010 TKKSGAAEAQV----EEVQPQKEEAPQTSTTTQPSASNGASHGVPQAELAGETNATGDTLKRQRI 1070
            :.|.|..:..:    :.:.|..:...|:..|...:|:...|
Human   835 SVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGS------------------------ 875

  Fly  1071 DLKGPRVKHVCRSASIVLGQPLATFGEDQQPEDAADMQQEIAAPVPSAIMEPSPEKPTHIV---- 1131
                ..:.||...|...:              :|.|.||.  .|:..|::....|...::|
Human   876 ----VEICHVLLQAGANI--------------NAVDKQQR--TPLMEAVVNNHLEVARYMVQRGG 920

  Fly  1132 ---TDENDNCASC--KTSPVGDESKPSKSSGSAQAEVKKATALGKEGTASAAGGSSAKVTTRNAA 1191
               :.|.|. ::|  ..:.:|:....|....:.|.:|          .|..:||.:..:.   ||
Human   921 CVYSKEEDG-STCLHHAAKIGNLEMVSLLLSTGQVDV----------NAQDSGGWTPIIW---AA 971

  Fly  1192 VASNLIVAASKKQRNGDIATSSSVTQSSNQTQGRKTKEHRQQRTLISIDFWENYDPAEVCQTGFG 1256
            ...::.|......|..|:..:.:|::       |..:|..     |.: .|.::       ||..
Human   972 EHKHIEVIRMLLTRGADVTLTDNVSE-------RLVEEEN-----ICL-HWASF-------TGSA 1016

  Fly  1257 LIVTETVAQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVN 1321
            .|....:..|.........|..||...|  .|.||. ||                       .:.
Human  1017 AIAEVLLNARCDLHAVNYHGDTPLHIAA--RESYHD-CV-----------------------LLF 1055

  Fly  1322 ASTGPSSSLNQLTQRLNW-LCP-RCTVCYTCNMS------------SGSKVKCQKCQKNYHSTCL 1372
            .|.|.:..|........| |.| |..|.:...::            ...|:.|:...:.|.:.
Human  1056 LSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENV-- 1118

  Fly  1373 GTSKRLLGADRPLICVNCLKCKSC-------------STTKVSKFVGNLPMCTGCFKLRKKGNFC 1424
                       |:.|||.:..:.|             ||..:.:.:.:|..||...........|
Human  1119 -----------PIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLC 1172

  Fly  1425 -PICQRCYDDNDFDL----------KMMECGD-CGQWVHSKCEGLSD------EQY--------- 1462
             .:..||:.|.|..|          .:.||.. |..|.:.|...:..      :.|
Human  1173 GQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGV 1237

  Fly  1463 NLLSTLPESIEFICK 1477
            ..|.|:|:. .|||:
Human  1238 RALQTIPQG-TFICE 1251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390	15/95 (16%)
		PRK13914	<1006..>1224	CDD:237555	35/231 (15%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	15/77 (19%)
		PHD	1346..1390	CDD:214584	7/55 (13%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	18/82 (22%)
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781
		SET_KMT2A_2B	3575..3726	CDD:380947
EHMT2	XP_006715037.2	PHA03247	<126..382	CDD:223021	68/318 (21%)
		2A1904	<396..504	CDD:273344	30/138 (22%)
		EHMT_ZBD	598..727	CDD:411018	37/193 (19%)
		ANKYR	806..1072	CDD:440430	63/369 (17%)
		ANK repeat	864..893	CDD:293786	7/70 (10%)
		ANK repeat	928..960	CDD:293786	7/42 (17%)
		ANK repeat	962..993	CDD:293786	7/33 (21%)
		ANK repeat	1002..1033	CDD:293786	7/43 (16%)
		ANK repeat	1035..1066	CDD:293786	12/56 (21%)
		SET_EHMT2	1133..1371	CDD:380931	23/120 (19%)