DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trx and Nsd2

DIOPT Version :10

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:NP_001074571.2 Gene:Nsd2 / 107823 MGIID:1276574 Length:1366 Species:Mus musculus


Alignment Length:1584 Identity:297/1584 - (18%)
Similarity:471/1584 - (29%) Gaps:552/1584 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   616 FVLPKRSTRSSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGTSSSSAGSTASTF----SAST 676
            |.:.|......:::|..|        ..:.|..||.:.||    |.:.......|.|    ..|.
Mouse     3 FSIRKSPLSVQKVVKCMK--------MKQTPEILGSANGK----TQNCEVNHECSVFLSKAQLSN 55

  Fly   677 NLKLGKETFFN---------FGTLKPNSSAAGNFVLRQP-----RLQFQADNQQATFTAPKACPT 727
            :|:.|....||         ...||..:|...|   .:|     :|.|:|...:...|.|.   |
Mouse    56 SLQEGVMQKFNGHDALPFLPAEKLKDLTSCVFN---GEPGAHDTKLCFEAQEVKGIGTPPN---T 114

  Fly   728 SPSAIPKPANSLATSSFGSLASTNSSTVTPT---------PSACSICSAVVSSKEVTQAR----- 778
            :|.....|...|              .:|.|         .|.|...:|.||..|..:.:     
Mouse   115 TPIKNGSPEIKL--------------KITKTYMNGKPLFESSICGDGAADVSQSEENEQKSDNKT 165

  Fly   779 --------KY------GVVACDVCRKFFSKMTKKSISANSSTANTSSGSQQYLQCKGNEGS---- 825
                    ||      |:|...:..|..|...||......|..||  |..:.|..|.|.|.    
Mouse   166 RRNRKRSIKYDSLLEQGLVEAALVSKISSPADKKIPVKKESCPNT--GRDRDLLLKYNVGDLVWS 228

  Fly   826 --------PCSI------HSAKSQLKNFKK--------FYKDRCTACWL-KKCMISFQLPAAHRS 867
                    ||.:      |: .::||..||        |:.|.....|: :|.:::|:    ...
Mouse   229 KVSGYPWWPCMVSADPLLHN-HTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFE----GEE 288

  Fly   868 RLSAILPPGMRGEAAAREEKSAELLSP-TGSLRFTSTASSSSPSVVASTSVKWKSS-------GD 924
            :...:.....: :|..:.|| .:||.| :|.||.............||.|::.:.:       ||
Mouse   289 QFEKLCQESAK-QAPTKAEK-IKLLKPISGRLRAQWEMGIVQAEEAASMSIEERKAKFTFLYVGD 351

  Fly   925 STSALTSIKPNPLAENNVTFGSTPLLRPAILENPLFLKISNAADQKLAAAE-AISPSLTKKNSKQ 988
                  .:..||.........:.||              ....|...|:.| |:.|.        
Mouse   352 ------QLHLNPQVAKEAGIVTEPL--------------GEMVDSSGASEEAAVDPG-------- 388

  Fly   989 EKEKVKESEQSEKLLSPTQAGTKKSGAAEAQVEEVQPQKEEAPQTSTTTQPS-ASNGASHGVPQA 1052
                   |.:.|.:.:..:..||:|.:||.|        |..|.|..:|.|. |......||  .
Mouse   389 -------SVREEDIPTKRRRRTKRSSSAENQ--------EGDPGTDKSTPPKMAEAEPKRGV--G 436

  Fly  1053 ELAGETNATG----------------------DTLKRQRIDLKGPRVKHVCRSASIVLGQPLATF 1095
            ..||...:||                      |.:..:..|..|..::.       :||...:..
Mouse   437 SPAGRKKSTGSAPRSRKGDSAAQFLVFCQKHRDEVVAEHPDASGEEIEE-------LLGSQWSML 494

  Fly  1096 GEDQQPEDAADMQQEIAAPVPSAIMEPSPEKPTHIVTDENDNCASCKTSPVGDESKPSKSSGSAQ 1160
            .|.|:..........|:|.........:.:|.:|  |...|:.|    ..|..|..|.|...:.:
Mouse   495 NEKQKARYNTKFSLMISAQSEEDSGNGNGKKRSH--TKRADDPA----EDVDVEDAPRKRLRADK 553

  Fly  1161 AEVKK--ATALGKEGTASAAGGSSAKVTTRNAAVASNLIVAASK-KQRNGDIATSSSVTQ-SSNQ 1221
            ..::|  .|...|....|:.....|..:.::.|...||..|... |:||...||:||... :.:.
Mouse   554 HSLRKQRETITDKTARTSSYKAIEAASSLKSQAATKNLSDACKPLKKRNRASATASSALGFNKSS 618

  Fly  1222 TQGRKTKEHRQQRTLISIDFWENYDPAEVCQTGFGLIVTETVAQRAL-------CFLCGSTGLDP 1279
            :......||....:.........|:.|:..||...  |:...::|.:       |.||..||  .
Mouse   619 SPSASLTEHEVSDSPGDEPSESPYESADETQTEAS--VSSKKSERGMAAKKEYVCQLCEKTG--S 679

  Fly  1280 LIFC-ACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPR 1343
            |:.| ..||..:|..|                         :..|..|..         .:.|..
Mouse   680 LLLCEGPCCGAFHLAC-------------------------LGLSRRPEG---------RFTCTE 710

  Fly  1344 CT----VCYTCNMSSGSKVKC--QKCQKNYHSTCLGTSKRLLGADRPLIC--------------- 1387
            |.    .|:.|..|.....:|  .:|.|.||..|:......:...|...|               
Mouse   711 CASGIHSCFVCKESKMEVKRCVVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSCHASNPSN 775

  Fly  1388 --------VNCLKC-------KSCSTTKVSKFVGNLPMCTG------------------CFKLRK 1419
                    :.|::|       .:|.....|....|..:|||                  ||...|
Mouse   776 PRPSKGKMMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRHHTHVNVSWCFVCSK 840

  Fly  1420 KGNF--CPICQRCYDDNDFDLKMME----CGDC-------------------------------- 1446
            .|:.  |..|...:..:..:::|.:    |.||                                
Mouse   841 GGSLLCCEACPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNV 905

  Fly  1447 -----------GQ------------WVHSK-----CEGLSDEQYNLLSTLPESIEFICKKCARRN 1483
                       |:            |.|..     .||....:|..:..:....:...::...|.
Mouse   906 PPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARF 970

  Fly  1484 ESSKIKAEEWRQAVMEEFKASLYSVLKL---LSKSRQACALLKLSPRKKLRCTCGASSNQGKLQP 1545
            ...|::.|. |:....|.|...|..:|:   ..|.:...|.:...|    :|.|..:        
Mouse   971 NEVKLQREA-RETQESERKPPPYKHIKVNKPYGKVQIYTADISEIP----KCNCKPT-------- 1022

  Fly  1546 KALQFSSGSDNGLGSDGESQNSDDVYEFKDQ-----QQQQQQRNANMNKPRVKSLPCSCQQHISH 1605
                    .:|..|||.|..|...::|...|     :..|.|.......|..|.:.       :.
Mouse  1023 --------DENPCGSDSECLNRMLMFECHPQVCPAGEYCQNQCFTKRQYPETKIIK-------TD 1072

  Fly  1606 SQSFSLV---DIKQKIAGNSYVSLAEFNYDMSQVIQQSNC-------DELDIAYKELLSEQFPWF 1660
            .:.:.||   ||::....|.||         .::|.:..|       .|.||.:..:|:      
Mouse  1073 GKGWGLVAKRDIRKGEFVNEYV---------GELIDEEECMARIKYAHENDITHFYMLT------ 1122

  Fly  1661 QNETKACTDALEED-MFESCSGGNYEDLQDTGGVSASVYNEHS----------TSQAESRSG--- 1711
                      :::| :.::...|||           |.:..||          |...::|.|   
Mouse  1123 ----------IDKDRIIDAGPKGNY-----------SRFMNHSCQPNCETLKWTVNGDTRVGLFA 1166

  Fly  1712 VLDIPLEEVDDFGSCGIKMRLDTRM-CLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMW----- 1770
            |.|||         .|.::..:..: ||          |.|..:..||     .:||:.:     
Mouse  1167 VCDIP---------AGTELTFNYNLDCL----------GNEKTVCRCG-----ASNCSGFLGDRP 1207

  Fly  1771 --SAEVFEEIDG--SLQNVHSAVARGR-----MIKCTVCGNRGATVGCNVRSCGEHYHYPC---- 1822
              ||.:..|..|  :.:......|:|.     ..:|..||:.|..|.|:.:.|.:.||..|    
Mouse  1208 KTSASLSSEEKGKKAKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLG 1272

  Fly  1823 ------------------ARSIDCAFLTDKSMYCPAHAKNGNA---------------LKANGSP 1854
                              ..|.....|...| :|..| ::|.|               |:|:.|.
Mouse  1273 KRPFGKWECPWHHCDVCGKPSTSFCHLCPNS-FCKEH-QDGTAFRSTQDGQSYCCEHDLRADSSS 1335

  Fly  1855 SVTYESNFEVSRPVYVELDRKRKK 1878
            |...|..|    |..::...||||
Mouse  1336 STKTEKPF----PESLKSKGKRKK 1355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:413390 32/139 (23%)
PRK13914 <1006..>1224 CDD:237555 52/244 (21%)
PHD1_KMT2A_like 1268..1344 CDD:276981 14/83 (17%)
PHD 1346..1390 CDD:214584 11/68 (16%)
PHD3_KMT2A_like 1423..1479 CDD:276983 12/121 (10%)
ePHD_KMT2A_like 1737..1841 CDD:277134 28/139 (20%)
FYRN 1890..1937 CDD:461787
FYRC 3388..3476 CDD:197781
SET_KMT2A_2B 3575..3726 CDD:380947
Nsd2NP_001074571.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..169 4/19 (21%)
PWWP_NSD2_rpt1 220..347 CDD:438990 26/133 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 373..455 25/106 (24%)
HMG-box_NSD2 452..507 CDD:438807 7/61 (11%)
TNG2 <546..711 CDD:227367 39/202 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..659 14/65 (22%)
PHD1_NSD1_2 670..712 CDD:277118 14/77 (18%)
PHD2_NSD2 717..763 CDD:277121 11/45 (24%)
PHD3_NSD2 764..817 CDD:277124 7/52 (13%)
PHD_SF 834..874 CDD:473978 9/39 (23%)
PWWP_NSD2_rpt2 880..975 CDD:438993 7/94 (7%)
AWS 1013..1063 CDD:197795 13/69 (19%)
SET_NSD2 1063..1204 CDD:380988 38/207 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1207..1233 5/25 (20%)
PHD5_NSD2 1242..1284 CDD:277130 10/41 (24%)
C5HCH 1283..1328 CDD:465605 7/46 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1330..1366 10/30 (33%)
Blue background indicates that the domain is not in the aligned region.

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