Protein Alignment trx and ehmt2

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: XP_004917185.1
• Gene: ehmt2 / 100484992
• XenbaseID: XB-GENE-487387
• Length: 1150
• Species: Xenopus tropicalis
• Alignment Length: 1329
• Identity: 251/1329 - (18%)
• Similarity: 428/1329 - (32%)
• Gaps: 437/1329 - (32%)

  Fly  2617 PSNSGLQMLTAQSLQAQ--PQ--VIGTLIQPQTIQLGGGADGNQPGSNQQPLILGGTGGGSSGLE 2677
            |:....:||:|:....:  |:  ::|.     :..:..|.|..:..||.:.:
 Frog     4 PAGESERMLSAEGADKEGCPERDLVGL-----SASINSGDDNAEELSNTREI------------- 50

  Fly  2678 FATTSPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGM-LSQNASFSATTTQVFQASKIEPI 2741
                ||..::.|          |:....:.::.|:.:..|. ||.:||.|..|.....:|.|...
 Frog    51 ----SPADVIPT----------VEEKEETEKESVNISPVGRGLSGHASKSLPTPPSTSSSPISSR 101

  Fly  2742 VDLPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDD------TTTQILQNANFQFQSVPTSSGAS 2800
            ..:.     |..||....|...|  |..|...|:|.      ....|.:..|.....|..|.|..
 Frog   102 AKMS-----LTGTGKLPHAAQSL--AMRLLNITRDGADKVHRARKTIPRAVNVPGNGVLVSDGEK 159

  Fly  2801 TSMDYTSPVMVTAKIPPVTQIKRTNA---------QAKAAGISGVGKVPPQPQVVNKVLPTSIVT 2856
            .|:...|. |.|...|..|| ||:::         |::...:|.: .:.|:|.....  |..:..
 Frog   160 QSVRRESE-METRDSPDSTQ-KRSSSSLVADISANQSREVEVSSL-LLSPEPGSSRD--PEGVDA 219

  Fly  2857 QQSQVQV----------------KNSNLKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNMIRP 2905
            ::.:.:|                .:|:.|:.:.:.:..||..:      ..:|..::|||.
 Frog   220 EEWEPEVGAEFSLFYDSFSLEEQGDSDSKEEEDEEEEGSGNQS------ERSSSSMKKKTK---- 274

  Fly  2906 IHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQ 2970
             .|.::....:|||.|        .:::::::|          |..|..|.:|
 Frog   275 -KKWKMDKAWLKPTRK--------RKRREREKP----------VTAVSSVGVS------------ 308

  Fly  2971 LQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELAN-RVQHFSTS 3034
              .::...:|.....|        ||...::...|.|......|:.:..|:..|.: |::..|..
 Frog   309 --NSEYTEVPLGALDL--------PSEGTLSPNHAGVCNETSSMDTERYEELPLCSCRMEAPSVD 363

  Fly  3035 SSSSSSN--CSLPTNVVNPMQQQAPSTTSSSTTRPTNRVLPMQQRQEP----------------- 3080
            .....:|  |....:|...:.....:.|...|.||::|| |:....|.
 Frog   364 RVCEQANNMCMATESVDGELSGCNVTITKRETMRPSSRV-PLMVLCESHRARMVKHHCCPGCGYF 427

  Fly  3081 ------------------------APLSN--ECP------------VVSSPTPPKPVEQPIIH-- 3105
                                    :||:.  .||            .::....|.|:..|..|
 Frog   428 CTTGTFLECHPDFRINHRFHKACVSPLNGIIFCPHCGEDASEAEQITIAKADTPVPIPAPPHHDG 492

  Fly  3106 -------------QMTSASVSKCYAQKSTL------PSPVYEAELKVSS----------VLESIV 3141
                         :|......|..|.::|.      ||.:..:.:.:|:          .||..:
 Frog   493 GGPGRADTTQPSARMRGVGEGKRSALENTSNEEPQGPSVLLHSGVYLSTAGLPPGHARDALEKAL 557

  Fly  3142 PDVTMDAILEEQ---PVTESIY-------------TEGLYEKNSPGE-SKTEQLLLQQQQREQLN 3189
            .....|::|:.:   .:|||:.             :..||.....|| .|...:|:..|....||
 Frog   558 QSQETDSLLQGRNCHSLTESLLQQKRDRRKKIRYNSRQLYLSVKQGELQKVLLMLMDNQDSNFLN 622

  Fly  3190 QQLVNNG--------------YLLDKHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMA-TSACN 3239
            .|.:...              ::|.:....:...| .|.|...||...:...|.:..:. ..||.
 Frog   623 DQQLKRSPLHAAAQRGSLELCHILVQAGASINSTD-KVLRTPLLEAVVNNHIDIAKYLVQCGACV 686

  Fly  3240 DHEMSDSE---EPAVKDKISKILDNLTNDDCADSIATATTMEVDASA----GYQQMV-------E 3290
            .|:..|..   ..|.|....::|..|           .:|.:|:.:|    |:..::       .
 Frog   687 YHKEEDGSTCLHHAAKSGNLELLCFL-----------LSTGQVNVNAQDNGGWTPIIWAAEHKHI 740

  Fly  3291 DVLATTAAQSAPTEEFEG--------ALETAAVEAAATYINEMADAHVLDLKQ------------ 3335
            ||:.|...:.|.....:.        |..|.:.|.|...:|...|.|.::...
 Frog   741 DVIRTLLTRGADVTLQDNEKNICLHWASFTGSAEIAEVLLNAQCDLHAVNFHGDTPLHIASREGF 805

  Fly  3336 -------LQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQPIQEPKKMTGPHLLYEI 3393
                   |..|.:.|:|..:.:                             .|..:|..|
 Frog   806 IQCVNLFLSRGADTEIRNNEGD-----------------------------TPCDLTLEH----- 836

  Fly  3394 QSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNA-----LKYL 3453
                         |::|    .|:|:.|:..             .||....::|..     :.:.
 Frog   837 -------------TDVW----YALQLNRKIR-------------QGINNRAVRTERIISRDIAHG 871

  Fly  3454 IEQLP-----GVEKCSKYTP---KYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLD 3510
            .|::|     ||::  :..|   ||...|...|                  |:|:....:|  |.
 Frog   872 YERVPIPCVNGVDE--ELCPDDYKYVSENCETS------------------AMSIDRNITH--LQ 914

  Fly  3511 YGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRRGTGSNLPM 3575
            ..|..|:...:  :|. |...|.|..||....|.....|      ::|   .|:.......:...
 Frog   915 NCSCVDDCSSS--NCL-CGQLSIRCWYDKDGRLLQEFNK------IEP---PLIFECNQACSCWQ 967

  Fly  3576 AMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIG 3640
            ..|.|.::...|..:.::|:...|.|:...:.|..|..:.||.||||.....|.||.  ||
 Frog   968 TCKNRVVQSGIKVRLQLYRTAKMGWGVRALQAIPQGTFICEYVGELISDAEADVRED--DS---- 1026

  Fly  3641 CYMFKIDDN----LVVDATMRGNAARFINHCCEPNCYSKVVDILGHK-----HIIIFALRRIVQG 3696
             |:|.:|:.    ..:||...||.:|||||.||||.....| .:.|:     .|..|:.|.|..|
 Frog  1027 -YLFDLDNKDGEVYCIDARYYGNVSRFINHLCEPNLIPVRV-FMSHQDLRFPRIAFFSGRDIRAG 1089

  Fly  3697 EELTYDYKFPFEDEK---IPCSCGSKRCR 3722
            |||.:||...|.|.|   ..|.|||:||:
 Frog  1090 EELGFDYGDRFWDIKSKYFTCQCGSERCK 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	17/100 (17%)
		SET_KMT2A_2B	3575..3726	CDD:380947	56/160 (35%)
ehmt2	XP_004917185.1	EHMT_ZBD	348..477	CDD:411018	19/129 (15%)
		ANKYR	574..861	CDD:440430	57/362 (16%)
		ANK repeat	628..657	CDD:293786	1/28 (4%)
		ANK repeat	659..690	CDD:293786	8/30 (27%)
		ANK repeat	692..724	CDD:293786	8/42 (19%)
		ANK repeat	727..757	CDD:293786	5/29 (17%)
		ANK repeat	759..790	CDD:293786	7/30 (23%)
		ANK repeat	792..823	CDD:293786	3/30 (10%)
		SET_EHMT2	890..1128	CDD:380931	76/269 (28%)