DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and kmt2a

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	XP_031762525.1	Gene:	kmt2a / 100135006	XenbaseID:	XB-GENE-922912	Length:	3848	Species:	Xenopus tropicalis

Alignment Length:	4281	Identity:	963/4281 - (22%)
Similarity:	1508/4281 - (35%)	Gaps:	1331/4281 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 QLNSPVVDNPSP--SPPIASGST-PSVEGGIGVGGV-----VSPGEDAALKRVLTEMPNEVARDP 377
            :|::.::|:.|.  |.|.||||. .|..|.:..||.     |:.|.|||| :|...:.|.:.|..
Frog    24 RLSAILIDDVSEYRSNPGASGSAGASSAGTLAPGGPGNCLGVALGFDAAL-QVSAAIGNNLRRFR 87

  Fly   378 SPSSCTAAANGAASGKGS---ASNGPPAMASSGDGSSPK------------SGADTGPSTSSTTA 427
            ..|..::.......|.||   .....||.:.....:..|            |.|.:....::|:.
Frog    88 DVSGGSSGEEEQFLGFGSDEEVKGRSPAKSPKDQTTQRKPRGRPRNSLSRCSDASSNLCENTTST 152

  Fly   428 KQKKTVTFRNVLETSDDKSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYSRGGECIVRP-SILSKI 491
            ..|:.....:.::..:.|:..|:...|    |....:|   ...|.....|.|.|..| ...||.
Frog   153 LNKQETRLLDKVKKPESKTEEKKRGRP----PAHGNVK---FKLPQEKRDGTESIKAPCEEKSKR 210

  Fly   492 LNKNSNIDKLNSLKFRSAGASSSSSNQESGSSSNVFGLSRAFGAPMDEDDEGGVTF-RRNDSPED 555
            ...::.......:|...||   ..|..:|...||...|.|          :|||:. ||...|..
Frog   211 RKPSATFQHAAKIKKLRAG---KLSPLKSKFKSNKLKLGR----------KGGVSIVRRRGRPPS 262

  Fly   556 QNNAEDD---------------EMDDDDDDEEAEEDDE-----------------NEDDNDEAVS 588
            ....:.|               ..:.|...:.::||..                 :....|.|::
Frog   263 SERFKTDTHGSFPKQVPTDRSQRGNKDVSPQPSKEDTRVSVRQSPRRMKPVRIIPSSKRTDTAIA 327

  Fly   589 EKSAETEKSAGADERDPDE----------KQLVMDSHFVLPKRSTRSSRIIKPNKRLLEE----- 638
            ::..:..|. ||.::...|          .||.....|::|..||.||||||..:|.:|:
Frog   328 KQLLQKAKK-GAQKKMELEAAKLQGRKGGTQLKNIRQFIMPVVSTVSSRIIKTPRRFIEDEDYEP 391

  Fly   639 -------------GAISTKKPLSLGDSKGKNVFGTSSSSAGSTASTFSA-----STNLKLGKETF 685
                         ...||   .|.|.|:..:.....||.|.|..|..|:     ||..:..:||.
Frog   392 PIKIARLESAPNGSRFST---ASCGSSEKSSAASQQSSQATSDDSRSSSPSVDTSTESQASEETP 453

  Fly   686 F-------------------------------------NFGTLKPNSSAAGNFVLRQPRLQFQAD 713
            .                                     ||     :|..|...||| |..|
Frog   454 VVSEPQGRVAETITSVPTQQQPLESNGVRTRRLPVCNKNF-----SSRPAKKIVLR-PSFQ---- 508

  Fly   714 NQQATFTAP-----KACPTSPSA-IP------KPANSLAT---SSFGSLASTNSSTVTPTPSACS 763
             |:::.:.|     ...|..||| :|      .||..:||   |:........|....||....|
Frog   509 -QKSSVSPPPPLLSPPTPLQPSASLPDHTPWLMPAIPMATPFISASRMHEKRRSILREPTFRWTS 572

  Fly   764 ICSAVVSSKEVTQAR--KYGVVACDVCRKFF-SKMTKKSI---SANSSTANTSSGSQQYLQCKGN 822
            :..:.:.|:..:.|:  |.|::...:...|. ..:|.:.:   :|:...::|..|..:......:
Frog   573 LKHSRLESQYFSSAKYAKEGLIRKPIFDNFRPPPLTPEDVGLATASGFPSHTVVGPGRLFSHIHS 637

  Fly   823 EGSPCSIHSAKSQLKNFKKFYKDRCTACWLKKCMISFQLPAAHRSRL--SAILPPGMRGEAA--- 882
            .|:...:|. :|.|....:|                  .|:...||:  |..|||. .|.|:
Frog   638 SGARFDVHK-RSPLLRAPRF------------------TPSEAHSRIFESVTLPPS-AGRASGTS 682

  Fly   883 -----AREEK--------SAELLSPTGSLRFTS-TASSSSPSVVASTSVKWKSSGDSTSALTSIK 933
                 :|..|        |:|..||:.|:|..| ...:||.||:||         ..:|:||.|.
Frog   683 SMMGISRRSKRRVFNPIRSSEPKSPSHSMRTRSRRVGNSSLSVLAS---------PPSSSLTDIS 738

  Fly   934 PNPLA-----------ENNVT-----------------------FGSTPLLRPAILENPLF---L 961
            .:|||           .::||                       |.|:|...||:.  |.|   :
Frog   739 VSPLATSALNPSFPFSSSSVTPASVDIAEKIQKPRKPTSTPAEHFTSSPSSSPALF--PWFPSSV 801

  Fly   962 KISNAADQKLAAAEAISPSLTKKNSKQEKEK---------------------VKESEQSEKLLSP 1005
            ::.....:...:.|:......:||.::::||                     .:|....|.:::.
Frog   802 QMEKGKSKNRGSVESSKEREVEKNREKDREKENSRDSRRDKRKKSSDSGCKISRERNDEEGIVTA 866

  Fly  1006 TQ---AGTKKSGAAEAQVEEVQP----------------------QKEE------APQTSTTTQP 1039
            ||   :..||....|:.| ::.|                      :|.|      :|...|..|.
Frog   867 TQIKMSVRKKPVTVESNV-DISPASIHTDQIPAKNKISKKGRPVSEKTELDTCAKSPTAETQAQL 930

  Fly  1040 SA---------SNGASHGVPQAE------------------------------LAGETNATGDTL 1065
            .|         |...|..:.||:                              ...:..|.|...
Frog   931 PAQPVSALKHPSTSISSMLAQADKFPVSDKHVATLLRKAKAQLCKIEKSKFLKQTDQPKAQGQES 995

  Fly  1066 KRQRIDLKGPRVKHVCRSASIVLGQPLATFGEDQQPEDAA--------------DMQQEIAA--- 1113
            ......::|||:|||||.|::.||:..|.|.:|.....|.              |.:..||.
Frog   996 DSSEASVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKVLSSMGNDDKSSIAGSED 1060

  Fly  1114 ---PVP-----------SAIMEPSPEK----------PTHIVTDENDNCASCKTSP--------- 1145
               |.|           .|..||..:|          |...|.|:...|.:|...|
Frog  1061 ADQPAPPLKPIKQITRNKAQQEPPVKKGRRSRRCGQCPGCQVPDDCGICTNCLDKPKFGGRNIKK 1125

  Fly  1146 ----------------------------------------------------VGDESKPSKSSGS 1158
                                                                |...|.|..||..
Frog  1126 QCCKMRKCQNLQWMPSKAYLQKQAKAAKKKERKCKVTEKKELLPVKSPSELIVKPVSAPGTSSPP 1190

  Fly  1159 AQAE-------------VKKATALGKEGTASAAGGSSAK------VTTR------NAAVASNLIV 1198
            .|.|             .||.|....|....||..|..|      .||:      :..:|...:.
Frog  1191 VQEEPATPSLPQKKNEPPKKQTEEKSEEQIPAASTSETKQSPNSRKTTKQPPSQPSTTIAMTPLT 1255

  Fly  1199 A--ASKKQRNGDIATSSSVTQSSNQTQGRKTKEHRQQR--------------------------- 1234
            |  ::||:....|...|...|.........|::::|::
Frog  1256 ATPSTKKEAPKPIPPESRKKQPPVLPDNTSTEQNKQKKLAMRLGALLKSKGKEKDKPQPPSKPEV 1320

  Fly  1235 ------TL-----------------ISIDFWENYDPAEVCQT-GFGLIVTETVAQRALCFLCGST 1275
                  ||                 |.:||..:.:...|... |..|:.|..|..|.:||||.|:
Frog  1321 SFNLLNTLCNGGITKQKPPSDGVHRIRVDFKHDCEVENVWDMGGISLLTTAPVTPRVVCFLCASS 1385

  Fly  1276 GLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWL 1340
            |....::|..||||:|::|:::.........|                              ||.
Frog  1386 GHVEFVYCQVCCEPFHRFCLEERERPSEDQIE------------------------------NWC 1420

  Fly  1341 CPRCTVCYTC------------------NMSSGSKVKCQKCQKNYHSTCLG-------TSKRLLG 1380
            |..|..|:.|                  :||....::|.||:.:||..|||       |.|:
Frog  1421 CRHCKFCHVCGRQQQATKESIGRQNTISDMSLKQLLECNKCRNSYHPECLGPNYPTKPTKKK--- 1482

  Fly  1381 ADRPLICVNCLKCKSCSTTKVSK-----FVGNLPMCTGCFKLRKKGNFCPICQRCYDDNDFDLKM 1440
              |..||..|::||||.:|...|     :..:..:|..|.||..||||||:|.:||||:|::.||
Frog  1483 --RVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCNKCYDDDDYESKM 1545

  Fly  1441 MECGDCGQWVHSKCEGLSDEQYNLLSTLPESIEFICKKCARRNESSKIKAEEWRQAVMEEFKASL 1505
            |:||.|.:|||||||.|:||.|.:||.||||:.:.|..|..|:.:      |||.|:..|.:|||
Frog  1546 MQCGKCDRWVHSKCENLTDEMYEILSNLPESVAYTCINCTERHPA------EWRMALTNELQASL 1604

  Fly  1506 YSVLKLLSKSRQACALLKLSPRKKLRCTCGASSNQGKLQPKALQFSSGSDNGLGSDGESQNSDDV 1570
            ..||..|..||.:..||:          |..::....|.|:       .|..:.|...::..|..
Frog  1605 RYVLTALLNSRTSSHLLR----------CRQAAKPPDLNPE-------PDENMPSRSSAEGPDPP 1652

  Fly  1571 YEFKDQQQQQQQRNANMNKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSYVSLAEFNYDMSQ 1635
            ...:..:|.:|                         ....|..:|:|:....|.|:.|.:.|:.:
Frog  1653 ILTQVGKQDEQ-------------------------PPLDLEGVKRKMDHGKYKSVLEMSDDIVR 1692

  Fly  1636 VIQQS-NCD----ELDIA---YKELLSEQ----FPWFQ---------NETKACTDALEEDMFESC 1679
            :||.: |.|    ||..|   .|...:.|    ||||.         |:..:.:..|...:....
Frog  1693 IIQAAMNADGGQPELKKANSMVKSFFTRQMERVFPWFSVKKSRFWEPNKVTSNSSMLPNAVLPPS 1757

  Fly  1680 SGGNYEDLQDTGGVSA----------SVYNEHSTSQAESRSGV---------LDIPLEEVDDF-G 1724
            ...||...|:.....|          ......|....||...|         .::..||..:. .
Frog  1758 LDHNYAQWQERENRLAMQPVLMKKIIPAPKPRSPGDPESPQPVQPSTPPAPTTELNREESPELPP 1822

  Fly  1725 SCGIKMRLDTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAV 1789
            ..|::   |.|.|..|.|.|:..:.:..||||.|.|.|.|.|||:|||||||:.||||:|||.||
Frog  1823 PPGLE---DNRQCALCLKYGDDNANDAGRLLYIGQDEWTHVNCALWSAEVFEDDDGSLKNVHMAV 1884

  Fly  1790 ARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDCAFLTDKSMYCPAHAK--NGNALKANG 1852
            .||:.::|.:|...||||||.:.||..:||:.|:|..:|.||.||.:||..|..  .|..:..||
Frog  1885 IRGKQLRCELCLKLGATVGCCLTSCTSNYHFMCSRKKNCVFLEDKKVYCQKHKDLIKGEIVSDNG 1949

  Fly  1853 SPSVTYESNFEVSRPVYVELD---RKRKKL--IEPARVQFHIGSLEVRQLGAIVPRFSDSYEAVV 1912
                     |||.|.|:|:.:   .:||.|  :||..:...|||:.:..|| |:...||..:.:.
Frog  1950 ---------FEVLRRVFVDFEGITLRRKFLNGLEPDNIHIMIGSMTIDCLG-ILSDLSDCEQKLF 2004

  Fly  1913 PINFLCSRLYWSSKEPWKIVEYT--------------VRTTIQNSSSTLTA-------LDVGRNY 1956
            ||.:.|||:|||:.:..|...||              :.:|:|:..:...|       .||..|.
Frog  2005 PIGYQCSRVYWSTTDARKRCVYTCKILECRPPPADPDINSTVQHEENRTIAHSPQSLHSDVQENQ 2069

  Fly  1957 TVDH---------TNPNS-------KEVQLGMAQIARWH----TSLARSEFLENGGTDWSGEFPN 2001
            :.|.         ::|:|       |..::|.....|.|    :...||          .|..|.
Frog  2070 STDGIKCIETLCLSSPDSVSAASVTKPWEVGRPSGCRTHIPRYSPSQRS----------PGSRPL 2124

  Fly  2002 PNSCVPPDENTEE-----EP------------QQQADLLPPELKDAIFEDLPHELLDGISMLDIF 2049
            | |...|...|.|     :|            :..:..|.|:....||.  ||
Frog  2125 P-SAGSPSPVTHEIVTVGDPLLSSGLRKIGSRRHSSSSLSPQQHKKIFS--PH------------ 2174

  Fly  2050 LYDDKTDLFAISEQSKDGTQAMTSNQAQNQNQQAGGANSVSICDEDTRNSNTSLGNGWPASNPVE 2114
               .:||:.... |...|....:...:.|.:....||:::|      ..|:.|...|..|   :|
Frog  2175 ---PQTDISRFG-QPLQGIPVNSLENSGNGDPVCIGASTIS------SKSSCSPNTGQKA---IE 2226

  Fly  2115 DAMLSA--ARNSSQVQMLKTLAWPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNKKEMAT 2177
            ..:..|  ||.:..::....::.||.:         |.:..|..:::.     ||:..:.|..:
Frog  2227 CKLEKAPEARRTGFLETPSKVSTPKTE---------KVKTASPRVSDP-----SSEHPSPKVPS- 2276

  Fly  2178 VAGVSRRQSISETSVEGVATTSGSVRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSIT- 2241
                    .:.|.:.:.....:|.::..    |.|...|:.|...:.   .::::.|....|:.
Frog  2277 --------QVQEMTADASKNKAGCLKDS----SPALLNFKTSSNMQH---QKVIRRDNDRQSVVT 2326

  Fly  2242 -----------EFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDAFQRHLPSCSPTMSSN-ETES 2294
                       ..:|::.:..:|..: ..:||..|.... .:.|......||.:.....| :.|.
Frog  2327 QGETPSLEKGKNSQILASNHGISVHK-DRRVKTKRSMLD-NSKDKHSSKPPSDNEHAPDNRQNEP 2389

  Fly  2295 DVSGQGMTNNATQISAESLNELQKQLLANAGGLNYLQSATSFPQVQSLGSLGQ--FGLQGLQQLQ 2357
            |.:|..|.::.....|    .|.|:.:.|  |::...::.|...:.|.|.|.|  .|:.|...::
Frog  2390 DTNGNHMLSDTLSFRA----HLLKKSIDN--GISSPGNSQSEETLVSAGKLPQTKMGIDGGCNIE 2448

  Fly  2358 LQPQSLGSGFFLSQPNPATQANTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQPQLIAV--- 2419
            :..|:             |.:.....::..|......::..|...::|....|.::||..:.
Frog  2449 IAKQT-------------TSSANQSAELADNEKHKCVSDGTGDVPVSQTNSNADSEPQTGSAYPI 2500

  Fly  2420 -----------STNPDGTQQFIQIPQTMQATTTPTATYQTLQATNTDKKIMLPLTAA--GKP--- 2468
                       .|..||:.:.....::.:|.:........|....:..:..||..::  ||.
Frog  2501 QESSLVHQDGSKTQEDGSYKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDLPFCSSTPGKKRGK 2565

  Fly  2469 --------------------------LKTVATKAAQQAAV----KQRQLKSGHQVKPIQAKLQPH 2503
                                      .:||.|...::..:    :|...:..|::
Frog  2566 RAAEGQVDGADDISTSDDDDVYYYNFSRTVVTPGDERLGIHTLFRQDDQRDLHKI---------- 2620

  Fly  2504 PQQHQQQQQTQVQQPITVMGQNLLQPQLLFQSSTQTQAPQIILPQAQPQNIISFVTGDGSQGQPL 2568
            ||......:.:....:||...:    |...:|..|..|.::..|:.|.:.  |.| |.|
Frog  2621 PQLDGVDDEAECNTSVTVTKSS----QAGKRSGKQNGAGKLQTPEGQLEK--SHV-GKG------ 2672

  Fly  2569 QYISIPTAGEYKPQPQPTATPTFLTTAP-----GAGATYLQT---------------DASGNL-- 2611
            |..|.|.........|.|.........|     |:....|.|               |..||:
Frog  2673 QKTSEPKIENCHAVKQDTLEAQLALDTPRRAHSGSEKNLLDTFNSDLLKSDSDNNNSDDCGNILP 2737

  Fly  2612 ------VLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILGGTG 2670
                  ||..|||...|                               |..|.|:...|:..|.|
Frog  2738 SDIMDFVLKNTPSMQAL-------------------------------GESPESSSSELLTLGDG 2771

  Fly  2671 -------GGSSGLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQF------------VSTAMP 2716
                   |...|| |...|.|:     |....::..|..|:...:||            ::|..|
Frog  2772 LGLDNNRGKEMGL-FEVFSQQL-----PTSEPVDGAVPTTISGEEQFELPLELPSDLSVLTTRSP 2830

  Fly  2717 GMLSQN-----------------ASFSATTTQVFQASKIEPIVDLPAGYVVLNNTGDASSAGTFL 2764
            .:.|||                 .|..|.||......|...:.:...    ....||:|..|..|
Frog  2831 ALPSQNHSRLGVITDSQLSTSGERSLLAITTSSDTVEKRVTVTEKSG----TPGDGDSSLLGQNL 2891

  Fly  2765 NAAS-------------VLQQQTQDDTTTQILQNA------NFQFQSVPTSSGASTSMDYTSPVM 2810
            :.||             :.|:.....|..|:....      |....::..|...|.|:.....:.
Frog  2892 DRASEGHITPDRFITGHIDQEHISSPTCGQVDHTGREERARNSSTPNLQVSVSPSVSIQNQKYIP 2956

  Fly  2811 VTAKIPPVTQIKRTNAQAKAAGISGVGKVPP----------QPQVVNKVLPTSIVTQQSQVQVK- 2864
            .:::.|..:||.....|:....:    |.|.          ||..|.:.||.. |||:.|:...
Frog  2957 SSSESPGTSQIPSNTIQSTPQHL----KSPAEKLVVVNQNMQPLYVLQTLPNG-VTQKIQLAPSV 3016

  Fly  2865 --NSNLKQSQVKGKAASGTGTTCGAP--PSIASKPLQKKTNMIRPIHKLEVKPKVMKP----TPK 2921
              :|:..:.:|...:..|.|.|....  |::.|........::...|...::|....|    .|.
Frog  3017 PTSSSRTEGEVPVLSPMGGGLTLATALNPTLTSTFPSASKGILPMSHHPHLQPFPGGPQTTFLPN 3081

  Fly  2922 VQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPK----VTISQQRIPAQTQQQQLQQAQMIHIPQQ 2982
            :.||:..||...|....      |:::|::..:    .:.|....|...:::|:.:   :|..:.
Frog  3082 LNNQSSGLLIGVQPSSE------PSLLVSETGQRSDVGSTSNTSAPGMNKKRQITR---LHTRKN 3137

  Fly  2983 QQ------PLQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANRVQHFSTSSSSSSSN 3041
            ::      |..:....|..:|.:|..|.:.:. .........::...:.|...|.:..|...:|.
Frog  3138 KKLAPSVSPASRHAPDVVSNMTLINFAPSQIT-GALTSHTGLIDLGTIGNTAPHRNIPSIIKTSK 3201

  Fly  3042 CS---------LPTNV-VNPMQQQAPS------------TTSSSTTRPTNRVLPMQQRQEPAPLS 3084
            ..         ||.|| .:.....|||            .||.:|..|...|:.||......|:|
Frog  3202 SGVMYFDQTPLLPQNVGTSSSMGTAPSVIGLDTGHLPGQVTSLATGSPVLNVVSMQPASAAPPVS 3266

  Fly  3085 NE----CPVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPS-PVYEAELKVSSVLES----- 3139
            ..    .|.:.:|:....:...:|  .||...........|||| |...::...|:.:.:
Frog  3267 GHVTLTSPGILNPSELNSISNFLI--KTSPQGLGIQDNHVTLPSGPGMFSQCSTSATIATTSSIC 3329

  Fly  3140 IVPDVTMDAILEEQPVTE-------------------SIYTEGLYEKNSPGESKTEQLLLQQQQR 3185
            :||......:...||:.:                   .|..|...|.|:  .:...|:|.:.:.:
Frog  3330 VVPSSQSVGMTLSQPINDPDCHYPISHHMNRLLNSRPQILPESSSETNA--RAPALQMLAESETK 3392

  Fly  3186 EQLNQQ---LVNNGYLLDKHT-----FQVEPMDTDVYREE----------DLEEEEDEDDDFSLK 3232
            ..:...   |..|...:.:.|     .|..|.|....:::          .::|.|..|
Frog  3393 LTVPTSALGLQRNPVAVPQKTKSKAKRQTAPADKTSRKKQKTLHLTPNPPTVQESERHD------ 3451

  Fly  3233 MATSACNDHEMSDSEEPAVKDKISKILDNLTNDDCADSIATATTMEVDASAGYQQMVED--VLAT 3295
              ..|.:||..:..|:....:.:...:.|              |.|....||...::.|  .|..
Frog  3452 --KPAASDHTGAHEEKVNTSELMVPSMKN--------------TAEPPLPAGQLAIISDPEPLLK 3500

  Fly  3296 TAAQSAPTEEFEGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRRKEE-------QRT 3353
            ...|..|..:                          |.||           |:|:       .|.
Frog  3501 ELCQQDPKHD--------------------------DSKQ-----------REEDTGFSSPLMRL 3528

  Fly  3354 VSQEQEQSKAAIVPTAAAPEPPQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQ 3418
            :.||:.:..:   ||           |.|..||  ||:||.|:|||...:.||.|.|:.:.|.||
Frog  3529 LQQERNRQGS---PT-----------EEKPKTG--LLFEISSDDGFQISAGSIEEAWKSLTEKVQ 3577

  Fly  3419 VARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANG 3483
            .||....|..|   ..|.:.|::|:|:..:|:.:|:|||.|..:|..|..::|:..|
Frog  3578 EARSNARLKQL---SFAGVSGLRMLGIVHDAVVFLVEQLYGANRCRNYKFRFHRPEG-------- 3631

  Fly  3484 AHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHR 3548
                                           ::|...|.:..||.|.:..:|.:|||::|||:||
Frog  3632 -------------------------------EEEPPINPHGSARAEVHRRKSAFDMFNFLASKHR 3665

  Fly  3549 KQPIQVFVQPSDNE------LVPRRGTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKD 3607
            :.|   ..:|:|.|      ...||.|..:|||.|::|.||:|.|:.|||:||.||||||:|.::
Frog  3666 QPP---EYKPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCRRN 3727

  Fly  3608 IEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNC 3672
            |:||||||||:|.:|||.||||||:|||.:|||||||:|||:.||||||.|||||||||.|||||
Frog  3728 IDAGEMVIEYSGNVIRSILTDKREKYYDGKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNC 3792

  Fly  3673 YSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFED--EKIPCSCGSKRCRKYLN 3726
            ||:|:.|.|.|||:|||:|:|.:|||||||||||.||  .|:.|:||:|:|||:||
Frog  3793 YSRVIPIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDANNKLACNCGTKKCRKFLN 3848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381	15/99 (15%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	17/75 (23%)
		PHD	1346..1390	CDD:214584	17/68 (25%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	33/55 (60%)
		ePHD_KMT2A_like	1737..1841	CDD:277134	54/103 (52%)
		FYRN	1891..1935	CDD:283589	15/43 (35%)
		FYRC	3388..3476	CDD:197781	32/87 (37%)
		SET	3590..3710	CDD:214614	90/121 (74%)
kmt2a	XP_031762525.1	PHA03247	<648..792	CDD:223021	39/171 (23%)
		zf-CXXC	1086..1133	CDD:366873	7/46 (15%)
		opacity_OapA	<1201..>1319	CDD:411470	19/117 (16%)
		PHD1_KMT2A	1378..1424	CDD:277063	17/75 (23%)
		PHD2_KMT2A	1426..1490	CDD:277065	17/68 (25%)
		PHD3_KMT2A	1528..1584	CDD:277067	33/55 (60%)
		Bromo_ALL-1	1607..1737	CDD:99925	35/171 (20%)
		ePHD_KMT2A	1830..1942	CDD:277163	56/111 (50%)
		FYRN	1983..2030	CDD:399155	18/47 (38%)
		FYRC	3548..3631	CDD:197781	32/85 (38%)
		SET_KMT2A_2B	3695..3848	CDD:380947	105/152 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3591
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	699	1.000	Inparanoid score	I659
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323459at33208
OrthoFinder	1	1.000	-	-		FOG0003601
OrthoInspector	1	1.000	-	-		otm48694
Panther	1	1.100	-	-	O	PTHR45838
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160