Protein Alignment trx and tcf20

DIOPT Version :9

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: XP_002934760.2
• Gene: tcf20 / 100038081
• XenbaseID: XB-GENE-484162
• Length: 1849
• Species: Xenopus tropicalis
• Alignment Length: 2168
• Identity: 422/2168 - (19%)
• Similarity: 671/2168 - (30%)
• Gaps: 745/2168 - (34%)

  Fly     4 SKFPGKPSKSINRKRISVLQLEDDAANPAEPQQPAPESQQPSGSGSGSSAAREKGNNCDNDEDDN 68
            :|..|.|:....::|.|         .|.:...| |::...||:..|:...|| |::.......:
 Frog    81 NKEGGTPASQTPQRRPS---------GPVQSYGP-PQANSSSGTNFGTPYGRE-GHHSQFANQHS 134

  Fly    69 APGGASISGNTASSSAGSGNSGNGSSSGSST------GSGSSGSGSTNGGSVNGGTHHKSAANLD 127
            |.|..|.......||...|.|...|...|..      .|..|.|.|.|..:..|.:|.:..
 Frog   135 AAGNLSQYSQDFPSSFSPGGSQYPSHVTSQQLRQQLYQSHQSLSQSGNPPTSAGASHLQQI---- 195

  Fly   128 KEAVTKDQNGDGDKTRGNVSSAPSG-KLSAAASGKALSKSSRTFSASTSVTSSGRSSGSSPDGNS 191
                          .|....::|:| :|.....|:....|..  |:|:|..||.|...:.|: ..
 Frog   196 --------------QRSTALNSPAGYQLRMGQYGQHYQPSPG--SSSSSFPSSQRFGQTGPN-YE 243

  Fly   192 GASSDGASS-------GISCGKSTAKSTEAS-------SGKLAKTTGAGTCSS----------AK 232
            |.|..||||       |.|.|.....|:.||       :.||.:..|.|....          :.
 Frog   244 GYSPGGASSTYESHMPGSSYGTQQGFSSYASQHMKSFETSKLPQNVGQGQSQQQQQTSHVMQYSN 308

  Fly   233 SSK----ASSGTTSEATTSGLSGACLKALFVATPATSTGLACALV-SPGGSSQGGTFPISAALLR 292
            |||    :.:|..|::.....|....:..|  :|.::...|.::| ||..||.......|.
 Frog   309 SSKLPLQSQTGQYSQSEVPVRSPMQFQQNF--SPISNPSPAASVVQSPSCSSTPSPLMTSG---- 367

  Fly   293 ARKNSNKKFKNLNLARGEVMLPSTSKLKQLNSPVVDNPSPSPPIASGSTPSVEG--GIGVGG--- 352
                     :||...:|.|.|.|.:::.|:      .|..||      ||...|  |.||.|
 Frog   368 ---------ENLTCGQGNVPLSSRNRILQM------MPQLSP------TPHGGGFKGFGVEGPPD 411

  Fly   353 --VVSPGED--AALKRVLTEMPNEV-------ARDPSPSS-------CTAAANGAASGKGSASNG 399
              :..||..  :||...:..:||.|       |..|:..|       ..:.||...|.:......
 Frog   412 KRLTDPGLSSLSALSSQVANLPNTVQHMLLSDALAPNKKSGKRTSRKADSCANSETSSQAEEQLK 476

  Fly   400 PPAMASSGDGSSPKSGAD--------TGPSTSS--------------------------TTAKQK 430
            .| ||.|.|||...|..|        :|.||||                          |.|::.
 Frog   477 SP-MAESLDGSCSSSSGDPGERVRQLSGQSTSSEAGYKGTSSEKPASPTQGWSTELSEKTQAEEV 540

  Fly   431 KTV-----TFRNVLETSDDKSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYSRGGECIVRPSILS- 489
            :||     ||:.|.:.| :|||                               |..:...::.:
 Frog   541 ETVPEATETFQEVSKVS-EKSV-------------------------------GVIVAMETVATR 573

  Fly   490 --KILNKNSNIDKLNSLKFRSAGASSSSSNQESGSSSNVFGLSRAFGAPMDEDDEGGVTFRRNDS 552
              |:..::|.:|                                                  ||.
 Frog   574 SEKVTEESSTLD--------------------------------------------------NDE 588

  Fly   553 PEDQNNAEDDEMDDDDDDEEAEEDDENEDDNDEAVSEKSAETEKSAGADERDPDEKQLVMDSHFV 617
            .|..:..|..|...|||:.:....|:|.:.:| |.|:....|..::..:.:.|      :.|.|.
 Frog   589 VETSSQPEVPETVKDDDNVKECPPDQNGEPSD-ADSQPVPITSSTSRTEAKSP------VGSGFS 646

  Fly   618 LPKRSTRSSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGTSSSSAGSTASTFSASTNLKLG- 681
            . |....|||           .|.:..:.|...||.|....|...|..|......|....:..|
 Frog   647 F-KEGATSSR-----------NASNLPQHLKTPDSAGCGGQGDKKSGTGRNDKYPSLLQEVLQGH 699

  Fly   682 --KETFFNFGTLKP----NSSAAG---NFVLRQ----PRLQFQADNQQATFTAPKACPTSPSAIP 733
              :|..:...|..|    .||.|.   |.::.|    |...............|...|....:.|
 Frog   700 HQQERRYARNTQDPPPVTGSSEASLRPNILMSQASELPNRNILGKTLAPHLETPNWGPWDRKSAP 764

  Fly   734 --KPANSLATSSFGSLASTNSSTVTPTPSACSICSAVVSSKEVTQARKYGVVACDV--CRKFFSK 794
              ||.|   .:.:    |.....|.| |::....|.:.|.:.        .|.||:  .|:....
 Frog   765 DVKPLN---VTDY----SARKFEVDP-PASSQESSGIPSERR--------SVICDISPLRQLVRD 813

  Fly   795 MTKKSISANSSTANTSSGSQQYLQC--------KGNEGSPCSIHSAKSQLKNFKKFYKDRCTACW 851
            .|.........:|:..||....|..        ..|:|.     :.|.|.....|.::.|.|
 Frog   814 PTASHHVGQERSADGRSGQSVILPSGMISLDAKSSNQGG-----TPKEQDTEATKMHRKRTT--- 870

  Fly   852 LKKCMISFQLPAAHRSRLSAILPPGMRGEAAAREE--KSAELLSPTGS-----LRFTSTASSSSP 909
             ..|:       .:.::.||      ||..:.|..  ...:..||..|     .|.|:...:...
 Frog   871 -DHCI-------PYSTKESA------RGNGSPRSMTFDPTQDYSPHNSRGPHPRRGTARVGARGR 921

  Fly   910 SVVASTSVKWK-SSGDSTSALTSIKPNP---LAENNVTFGSTPLLRPAILENPLFLKISNAADQK 970
            |.|.....|.| |.|.|.....:...||   |:|.    .|......|..:|.....:|..::.:
 Frog   922 SPVQDLGDKMKMSPGRSRGPAETHHMNPTMSLSER----ASREAFYSAFFQNADNAALSYHSNSR 982

  Fly   971 LAAAEAISPSLTK----KNSKQEKEKVKESEQSEKLLSPTQAGTKKSGAAEAQVEEVQPQKEE-- 1029
            .::.....|:.|.    |....::|:.||...| .:||.:|        ...:::...|::|:
 Frog   983 ASSYGEPHPTFTSPLHYKRPVYQQEEFKEWLGS-SILSASQ--------HRQEMQRKSPRQEQFH 1038

  Fly  1030 --AP-----QTSTTTQPSASNGASHGVPQAEL--------AGETNATGDTLKRQRIDLKGPRVK- 1078
              :|     :.....||    ||.|.....|.        .|.||.|...|||..  .|.|.|.
 Frog  1039 VRSPGRVENEVMVYNQP----GAYHDSSSLEYGRQLRVGEGGPTNLTALELKRNA--QKTPPVDS 1097

  Fly  1079 ---HVCRSASIV--LGQPLAT----FG-------------------------------EDQQPED 1103
               ::.|..|.|  ||.|:.|    |.                               |:|...:
 Frog  1098 TNWNLGRQTSPVKKLGSPVGTNQKPFSSGRETDTLVHRSGEGTEISKPGCNAHRPQGTEEQSHHN 1162

  Fly  1104 AADMQQEI---AAPVPSAIMEPSPEK---PTHIVTDENDNCASCKT----------SPVGDE--- 1149
            ...|::.:   .:|:||. .:|..:|   |...|.:.:|..:..:.          |||.||
 Frog  1163 PLIMRRRVRSFISPIPSK-RQPGDDKGRLPVSNVKETSDRTSVSQVLTSRSKESGFSPVADEPHK 1226

  Fly  1150 -----SKPSKSSGSAQAEVK----------KATALGKEGTASAAGGSSAKVTTRNAAVA---SNL 1196
                 :.||..|.|:.|:.|          |..|:.::.|:......||..::.:||.|   .::
 Frog  1227 GGPEQTSPSAVSLSSPAKTKILPPRKGRGLKLEAIVQKITSPNVRRISAPSSSESAAEAVTLDDI 1291

  Fly  1197 IVAASKKQRNG---------------DIATSSSVTQSSNQTQG--------RKTKEHRQQRTLIS 1238
            :....|...:|               ||:.|...|..|...:.        :|.|...:::::.:
 Frog  1292 LSLKIKGPESGKGSMQEAELPGVVGPDISCSEETTAKSLPPKSLDVWAHDEKKIKTEMEEQSMET 1356

  Fly  1239 IDFWENYDPAEVC---QTGFGLIVTETVAQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYN 1300
            .||..:..||:..   ..|.|.                ||.|:|.     |..|..|
 Frog  1357 KDFSMSGLPAQASNHYMDGKGT----------------STALEPK-----CVLPQVQ-------- 1392

  Fly  1301 LKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQK 1365
             :|.:.|...|.|:                                  .||::...:|   ..||
 Frog  1393 -QHENVEKEKLAGT----------------------------------PCNVTPKQEV---IPQK 1419

  Fly  1366 NYHSTCLGTSKRLLGADRPLICVNCLKCKSCSTTKVSKFVGNLPMCTGCFKLRKKGNFCPICQRC 1430
            .|..:  |..|     .||:..||                           .:||....|:
 Frog  1420 GYFPS--GKKK-----GRPVGSVN---------------------------KQKKQQQQPL---- 1446

  Fly  1431 YDDNDFDLKMMECGDCGQWVH---------SKCEGLS----DEQYNLLSTLPESIEFICKKCARR 1482
                     |.|.|      |         :....|.    ||..::....|:...   ::..||
 Frog  1447 ---------MQEQG------HQQPPPPVSPASVSALPPQHLDEHLDISEAEPKPKR---RRTERR 1493

  Fly  1483 NESSKIKAEEWRQA------VMEEFKASLYS--VLKLLSKSRQACALLKLSPRKKLRCTC----- 1534
            ..:...:....:||      :..|.|....|  :.|..:|::.....:.:..:::|..:|
 Frog  1494 KPTGAPRRRRGKQAAPIVAPIEPEIKLKYASQNLDKPETKTKSFIPYIHVENKEELGLSCVIINA 1558

  Fly  1535 -----------------GASSNQGKLQPKALQFSSGSDNG----------------LGSDGESQN 1566
                             .::|.|.....|||..||....|                .|.....:|
 Frog  1559 EEEEQHWKKLTSVRKGQRSASPQPSTDSKALPSSSFMVQGPVVTESATMGHLVCCLCGKWANYRN 1623

  Fly  1567 SDDVYEFKDQQQQQQQRNANMNKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSYVSLAEFNY 1631
            ..|:  |.....|:.....:.|.|..||           |::...|.::.|...:.
 Frog  1624 LGDL--FGPFYNQEYASTLSKNPPPKKS-----------SETPRKVKVRHKDTSDG--------- 1666

  Fly  1632 DMSQVIQQSNCDELDIAYKELLSEQ-----FPWF--QNETKACTDALEEDMFESCSGGNYEDLQD 1689
                  .:|:.||.:....:...||     .|.:  :|.:..||.:       ..:..::....|
 Frog  1667 ------SKSDSDEEEEEEPQQAREQRSLTAHPRYKRRNRSGDCTSS-------RLTVPSHRKTTD 1718

  Fly  1690 TGGVSASVYNEHSTSQAESRSGVLDIPLEEVDDFGSCGIKMRLDTRMCLFCRKSGEGLSGEEARL 1754
            ...::....:..||::|....|| .||            ::.||:
 Frog  1719 PSELTPMDSSGPSTAEAGPEQGV-QIP------------QLPLDS-------------------- 1750

  Fly  1755 LYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYH 1819
                ::.|:|..|.:|:..|: .:.|.|..:..||...|.:||:.|...|||:||..:.|...||
 Frog  1751 ----NEFWMHEGCVLWANGVY-FVCGRLYGLREAVDIAREMKCSHCQETGATLGCYNKGCACCYH 1810

  Fly  1820 YPCARSIDCAFLTDK-SMYCPAH 1841
            :|||...:|....:. |:.||.|
 Frog  1811 FPCAMDSECLLNEENFSVRCPKH 1833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381	18/103 (17%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	11/75 (15%)
		PHD	1346..1390	CDD:214584	11/43 (26%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	9/68 (13%)
		ePHD_KMT2A_like	1737..1841	CDD:277134	28/104 (27%)
		FYRN	1891..1935	CDD:283589
		FYRC	3388..3476	CDD:197781
		SET	3590..3710	CDD:214614
tcf20	XP_002934760.2	ePHD_TCF20	1612..1833	CDD:277169	59/293 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910