DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and tcf20

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	XP_005171593.1	Gene:	tcf20 / 100006417	ZFINID:	ZDB-GENE-110411-97	Length:	2354	Species:	Danio rerio

Alignment Length:	2551	Identity:	479/2551 - (18%)
Similarity:	745/2551 - (29%)	Gaps:	1020/2551 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SQQPSGSGSGSSAAREKGNNCDNDEDDNAPGGASISGNTASSSAGSGN----------------- 88
            ::.|..|..|:|..:           |:.....|:||...|...|:..
Zfish    84 TEMPQSSAGGNSYRK-----------DSMDYYFSVSGRDRSRRGGAAYGAGFRYTNVDGHQYQHL 137

  Fly    89 SGNGSSSG-----------SSTGSGSSGSGS----------------------------TNGGSV 114
            ||:|||||           :..||.||.:||                            ::.|.:
Zfish   138 SGSGSSSGMISPYSMDCGSAVVGSNSSAAGSFSPSQQYSMAHAASVQSSAQMHQRQKYPSHQGLL 202

  Fly   115 NGGTHHKSAANLDKEAVTKDQNGD------GDKTRGNVSSAPSGKLSAAASGKALSKSSRTFSAS 173
            :.|.||::.|          .:|:      |.....|.:|..||..::......:|.||     |
Zfish   203 HQGQHHRTYA----------LSGNRIPAQFGHYATINATSGSSGMYNSPPQRYDVSSSS-----S 252

  Fly   174 TSVTSSGRSSGSSPDGNSGASSDGASSGISCGKSTAKSTEASSGKLAKTTGAGTCSSAKSSKASS 238
            |....:...:.|:|:.:|.:|:..:...:..|.|::.....|...|.|                .
Zfish   253 TEAKINDSPTQSNPNHHSSSSASNSCEAMGQGYSSSAHPPYSPQSLHK----------------H 301

  Fly   239 GTTSEATT--SGLSG--ACLKALFVATPATSTGLACALVSPGGSSQGGTFPISAALLRARKNSNK 299
            |..|:.|.  |.::|  ..||...:.|....:.::.:...|..:.|..|            .|..
Zfish   302 GPHSQRTPQHSAVAGYDLSLKMQHLHTKLPHSSVSSSPSLPSHTPQDLT------------KSPM 354

  Fly   300 KFKNLNLARGEVMLPSTSKLKQLNSPVVDNPSPSP-----PIASGSTPSVEGGIGVGGVVSPGED 359
            ..:|           ..:::.|..|| :.||||:|     |..|.|:..:.|       ||.|..
Zfish   355 HTQN-----------QQAQIHQNFSP-ISNPSPAPSAVQSPSCSSSSSPLLG-------VSEGNS 400

  Fly   360 AALK-----------------RVLTEMPNEVARDPSP------SSC-------TAAANGAA---- 390
            |.|:                 |:|..:|.   ..|:|      |||       :|..|.:|
Zfish   401 AQLQASSHPAAPNARSSQSHARLLQAVPQ---LSPTPHSNSSISSCGSGGGNKSATLNHSAGIGH 462

  Fly   391 SGKGSASNGPPAMASSGDGSS--------PKSGADTGPSTSSTTAKQKKTVTFR----NVLETSD 443
            :..|....||...:..|:.||        |..|.::..:.:|.......||...    .||....
Zfish   463 ANMGQNRMGPGLRSGPGEDSSLFPHDKHLPDPGLNSLNALTSQVENLPNTVQHMLLTDTVLPQRK 527

  Fly   444 DKSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYSRGGECIVRPSIL-----SKILNKNSNIDKLNS 503
            .:.....|.           |::.|.:.|.|.::.|.......||     |::|..... .||..
Zfish   528 SRDAAPHFQ-----------MQQGSHSLPGNQNKSGNSSTAGRILTNEESSEMLETKGQ-QKLER 580

  Fly   504 LKFRSAGASSSSSNQESGSSSNVFGLSRAFGAPMDEDDEG-------GV--------TFRRND-- 551
            .:.|....:|:.|..:|...|     .|..  |.|:..:|       ||        :.|.:.
Zfish   581 KRVRQESGTSNESEPQSYLPS-----QRQM--PSDKSQQGLDLQVNTGVISTASKQSSVRESQAK 638

  Fly   552 ---------------------SPEDQ---------------NNAEDDEMDDDDDD---------- 570
                                 ||:.|               |:..|.::..||:.
Zfish   639 TPETLTPSSTSPPSGHPTAEPSPKLQVYPPAPASPIHSACLNSVADRDLGKDDEKGTKGPQIKMI 703

  Fly   571 EEAEEDDENED--------DNDEAVSEKSAETEKSAGADERDPDEKQLVMDSH------FVLPKR 621
            ::.|.|||..|        :|...|..|.||.|..|.:.| :|.:...|.:.|      .::..|
Zfish   704 KDEESDDECADPPCHRTSSENRLLVPLKQAERESCAQSLE-NPSKNVNVPEQHNVGGVGVIVSAR 767

  Fly   622 S---TRSSR----------------------------IIKPNKRLLEEGAISTKKPLSLGDSKGK 655
            |   |.||:                            ::|..:....||.:|.:..:|..|...|
Zfish   768 SELNTESSKHTGVKSPRYSVSHYPNKPSSIEEQHDVNVLKETRNQNGEGEMSMEAYVSQYDISPK 832

  Fly   656 NVFGTSSSSAGSTASTFSAS------TNLK----------LGKETFFNFGTLKPN------SSAA 698
            ..||.:..|..|...:|..|      |.:|          :|.....|:.||:.:      ...|
Zfish   833 REFGQNIVSVQSHPVSFKCSNPEVQYTAVKSKDKLGLGSVMGANRGQNYHTLQASYGSIARKEIA 897

  Fly   699 GNFVLRQPR----------LQFQ---------------------------------ADNQQATF- 719
            |.|.:...|          .|||                                 .|..|..|
Zfish   898 GVFAMEGGRGMVSRSQDNNSQFQQVFPSLLQEVLQGHHLDRRYVRAEQTSSAHQHSQDTSQHRFQ 962

  Fly   720 -------------------------------TAPKACPTS--------------PS--------- 730
                                           .||...|.|              ||
Zfish   963 TRLPYSMIENLSSHSMGSQSVMGGLNVQFSQLAPGKSPNSSQGPDSEIGLGPSHPSWDSEAHKTH 1027

  Fly   731 --AIPKPANSLATSSFGSL-ASTNSSTVTP----------------------------------T 758
              :|.|...||:.|....: .|.:.||..|                                  .
Zfish  1028 GISIEKSKTSLSPSQSSHMQQSLDLSTGAPPKHINLADYSLQHRKPSRYGTSPSAVEQLLLQEAE 1092

  Fly   759 PSACSI--CSAVVSSKEVTQARKYGVVACDVCRKFFSKMTKKSISANSSTANT-----SSGSQQY 816
            |.||::  ...|.|....:..|:  .|.|||..   |:.|.......||..:.     ||||.:.
Zfish  1093 PLACNVGPVGHVQSQASSSSGRR--SVICDVSP---SRRTTPERERGSSGPSVIQQPFSSGSNEQ 1152

  Fly   817 LQCKGNEGSPCSIHSAKSQLKNFKKFYK------DR-CTACWLKKCMISFQLPAAHRSRLSAILP 874
            ..||.      .|.:.|:|:|......:      || |:.            |.:..|......|
Zfish  1153 DCCKE------EIKAKKAQIKEDPSKVEAAGQNTDRYCST------------PPSKESNKPLRHP 1199

  Fly   875 ----PGMRGEAAAREEKSA----ELLS--PTGSLRFTSTASSSSPSVVASTSVKWKSSGDSTSAL 929
                |.:...::|:....|    ..||  ||..|.......|.|.:|....:..:..:.|....:
Zfish  1200 VDSDPDLEKTSSAKGNSDALSNLPYLSQMPTNPLSSPQRLQSFSQAVDGLRAYGFGDAMDGQKMI 1264

  Fly   930 TSIKP----NPLAENNVTFGSTPLLRPAILENPLFLKISNAAD-----QKLAAAEAISPSLTKKN 985
            ....|    :.|:....|..||..|:..    |..|...:..|     |||...:...|
Zfish  1265 PHAGPHQPFHTLSAYTKTTASTNKLQVF----PQSLPPQDRPDWTPDRQKLRGMDRHGP------ 1319

  Fly   986 SKQEKEKVKESEQSEKLLSPTQAGTKKS--GAA-EAQVEEVQPQKEEA-------PQTSTTTQPS 1040
            .:..::|.|....||.|.||.:...:.|  ||. :.::.:..|:||.|       |:....:||.
Zfish  1320 QRIPEQKCKSQPSSEILSSPHRISQQHSYPGAQFDLKMWDAYPEKEGAAQPLAAVPREHVGSQPI 1384

  Fly  1041 ASNG-----------------------------------ASHGVPQAELAGETNATGDT------ 1064
            .::|                                   |:.|:.|.:...:|.|..:|
Zfish  1385 TNSGPKIAKEDISDKGAEDTVKSFHSLAPASTNAGHTVKATQGIQQGQRVTKTGALAETNPLIMR 1449

  Fly  1065 -----------LKRQRIDLKGPRVKHVCRSASIVLGQPLATFGEDQQPED---------AADMQQ 1109
                       .|||..|:.|.|......|       |:|    ...||.         ::|.|.
Zfish  1450 RRVRSFISPIPAKRQHQDVPGQRPGSAYHS-------PIA----QAYPESRIATNSCSGSSDSQA 1503

  Fly  1110 EIAAPVPSAIMEPSPEKPTHIVTDENDNCASCKTSPVGDESK---PSKSSG-SAQAEVKKATALG 1170
            ::          |||:.| |.::..|        ||...::|   |.|..| ..:|.|:|.|.
Zfish  1504 KL----------PSPKTP-HSISSAN--------SPPQSKAKFLPPRKGRGLKLEAIVQKITP-- 1547

  Fly  1171 KEGTASAAGGSSAKVTTRNAAVASNLIVAASKKQRNGDIATSSSVTQSSNQTQGRKTKEHRQQRT 1235
                      ...|....|:.:.|:...||   ....|:....|.|..::.:||.:|
Zfish  1548 ----------GVRKNDFNNSNLESDFSEAA---HYTSDLPDPESGTSFTSVSQGEET-------- 1591

  Fly  1236 LISIDFWENYDPAEVCQTGFGLIVTETVAQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEY- 1299
                                           .|.:|..|..||.|:       ||.  .|:|.:
Zfish  1592 -------------------------------CLSYLEDSHTLDELM-------PYR--AVEDAFS 1616

  Fly  1300 ----NLKHGSF---------------------------------EDTTLMGSL-----LETTVNA 1322
                :||.|:.                                 ::.||:|.|     |...|..
Zfish  1617 CDSQSLKAGAAASSSGALRSLPKDFDFGLGTAGSSGSLGGENDKDEFTLLGPLPPAPPLPCPVQG 1681

  Fly  1323 STGPSSS----LNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQK-----------NYHSTCL 1372
            |..||||    :.|.|.....|..|      .:..|.:.:..||.|:           :|:.|..
Zfish  1682 SPPPSSSALSDIQQFTNTYQQLETR------RSEQSAANLLRQKLQETGMGFDDYPGGDYYGTTA 1740

  Fly  1373 G----------------TSKRLLGAD--------------------RPLICVNCLKCK--SCSTT 1399
            |                ||.||...|                    ||:..||..|..  ....|
Zfish  1741 GHSPGHHLLSRGSQNQMTSLRLTSPDSKASESTVPKGYFPSGKKKGRPVGSVNKQKRAQGQMQNT 1805

  Fly  1400 KVSKFVGNLPMCTGC---FKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHS------KCE 1455
            ..:.....||..|..   ..:....:..|......|:.          .|...|..      |.:
Zfish  1806 ATNIPAAPLPSPTAAPQSVSVSSNADEVPRVPTPPDEK----------PCPSLVPPDETQVVKVD 1860

  Fly  1456 GLSDEQYNLLSTLPE-SIEFICKKCARRNESSKIKAEEWRQ-------AVMEEF------KASLY 1506
            ..|:|      |||| .::.:.:|..:..|.|:..|....|       |..||.      :.|:
Zfish  1861 AESEE------TLPELDVKPVKQKQKKGKECSETPASSGNQRRRRRGMASKEELDTQTSSRGSI- 1918

  Fly  1507 SVLKLLSKSRQACALLKLSPRKKLR-----CT-CGASSNQGKLQPKALQFSSGSDNGLGSDGESQ 1565
            |:..:.|.:|.:.....:...||:.     || ..|...:.|        ..|.....|.||...
Zfish  1919 SLSGIFSDARNSVFAPYVHVEKKMEEIGAVCTIINAEDEKSK--------GGGKPGHTGVDGPLN 1975

  Fly  1566 N---SDDVYEFKDQQQQQQ---QRNANMNKPRVKSLP----------------------CSCQQH 1602
            .   |..|.:.|:.::.::   ....:......|:||                      |.||:.
Zfish  1976 TLLPSQLVRKEKENEKSKENWVSEQVDSTLESGKALPTSEYVLPGPVISETGHSGHLLCCLCQKW 2040

  Fly  1603 ISHSQSFSLVDIKQKIAGNSYVSLAEFNYDMSQVIQQSNCDELDIAYKELLSEQFPWFQNETKAC 1667
            .::..   |.|:........|.  |:...:..||             ::.||...|.....|...
Zfish  2041 ANYKH---LGDLYGPFYPAEYA--AKLPKNQPQV-------------RQTLSHFGPAATGMTSIP 2087

  Fly  1668 TDALEEDMFESCSGGNYEDLQDTGGVSASVYNEHSTSQ--------------------------- 1705
            |:|:.:|          ..||:...|.:|..::.:.||
Zfish  2088 TEAIPQD----------TRLQEPQNVKSSAESDCTVSQATNTTSPATIIGTVSPMPLEMPFQNAI 2142

  Fly  1706 ----------------AESRSGVLDIPLEEVD-DFGSCGIKM---------RLDTRMCLFCR--K 1742
                            ||..||:....|:|.| :..|..:::         |..|....|.|  |
Zfish  2143 ASSSTARVTTHAWDTAAELESGLGTSNLQETDAEIASKQLQVESSQQRPQHRKLTSHPRFKRRHK 2207

  Fly  1743 SGEGLS-----------------------GEEARLLYC------GHDCWVHTNCAMWSAEVFEEI 1778
            |.|.|.                       |..|:|...      ..:.|||.:|.:|::.:: .:
Zfish  2208 SSEDLPRTVPINSKASLPFQPPPPSLDALGPMAQLAQLPLVPLDPEELWVHESCMVWTSGIY-LV 2271

  Fly  1779 DGSLQNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDCAFLTDK-SMYCPAHA 1842
            :|.|..:..|:...|...|:.|...|:|:||..:.|...|||.||...||:...|. |:.||.|
Zfish  2272 NGRLYGLQEALDGARDASCSHCEMAGSTLGCYSKGCTLRYHYICAIDADCSLNEDNFSLRCPKH- 2335

  Fly  1843 KNGNALKANGSPSVTY 1858
             .||.:   ..|.|.|
Zfish  2336 -KGNRM---AKPGVVY 2347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381	25/107 (23%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	27/122 (22%)
		PHD	1346..1390	CDD:214584	15/90 (17%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	11/62 (18%)
		ePHD_KMT2A_like	1737..1841	CDD:277134	36/135 (27%)
		FYRN	1891..1935	CDD:283589
		FYRC	3388..3476	CDD:197781
		SET	3590..3710	CDD:214614
tcf20	XP_005171593.1	PHD_SF	2034..>2054	CDD:328929	5/22 (23%)
tcf20	XP_005171593.1	PHD_SF	<2254..2335	CDD:328929	27/81 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910