Protein Alignment MetRS-m and metG

DIOPT Version :10

• Sequence 1: NP_650348.1
• Gene: MetRS-m / 41733
• FlyBaseID: FBgn0027083
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_416617.1
• Gene: metG / 946643
• ECOCYCID: EG10586
• Length: 677
• Species: Escherichia coli
• Alignment Length: 602
• Identity: 142/602 - (23%)
• Similarity: 230/602 - (38%)
• Gaps: 122/602 - (20%)

  Fly    22 VTTPIFYVNAAPHIGHLYSAVIADAHCRYQRLRYPEQDVRLCTGTDEHGTKIQQAASLHGVPVAK 86
            ||..:.|.|.:.|:||:...:.||...||||:|  ..:|......|.|||.|...|...|:...:
E. coli    10 VTCALPYANGSIHLGHMLEHIQADVWVRYQRMR--GHEVNFICADDAHGTPIMLKAQQLGITPEQ 72

  Fly    87 YCDDISQRYREVFRSASIQQDDFIRTTEDRHKRAVANFWRTLHTRGHIYSAAYSGWYCVSDETFL 151
            ...::||.::..|...:|..|::..|..:.:::.....:..|...|.|.:...|..|......||
E. coli    73 MIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFL 137

  Fly   152 TDSQLRLD--------------EATGTRY---------SLESGHPVEWTEETNYMFRLSQFQDDV 193
            .|..::..              |..|..|         |:.||......:..::.|.|..|.:.:
E. coli   138 PDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEML 202

  Fly   194 RHWVKTEARVRPAKFEKILLDTLSEPLP------DVSVSRPSNRVHWAIPVPDDDSQTVYVWLDA 252
            :.|.::.|      .::.:.:.:.|...      |:|...|    ::...:|:...:..||||||
E. coli   203 QAWTRSGA------LQEQVANKMQEWFESGLQQWDISRDAP----YFGFEIPNAPGKYFYVWLDA 257

  Fly   253 LVNYLSSVGYPDEK------FSAHW-----PPAQQVIGKDILKFHGIYWTAFLLAAGLEPPGQLY 306
            .:.|:.|.....:|      |..:|     ......|||||:.||.::|.|.|..:....|..|:
E. coli   258 PIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPSNLF 322

  Fly   307 VHSHWTVDGQKMSKSKHNVVDPLQAAQQYTMEGLRYFL---LREGVAHSDGNYSHVKAQRILNSE 368
            ||.:.||:|.|||||:...:........:..:.|||:.   |...:...|.|.... .||: |::
E. coli   323 VHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDF-VQRV-NAD 385

  Fly   369 LADTLGNLLSRASAKSLNPGQI---YPSPSAEHLADLLRSLDVAKRLQDSLLQLSERCESHYECN 430
            :.:.:.||.||      |.|.|   :....|..|||        .:|..:....:|.....:|..
E. coli   386 IVNKVVNLASR------NAGFINKRFDGVLASELAD--------PQLYKTFTDAAEVIGEAWESR 436

  Fly   431 HFHLVADTTMAALHAANNFFESSKPWTLKAGAPDGNQARLETIIAMTMDALRLSGIVLQPIIPQL 495
            .|.......||....||.:.:...||.:  ...:|..|.|:.|.:|.::..|:....|:|::|:|
E. coli   437 EFGKAVREIMALADLANRYVDEQAPWVV--AKQEGRDADLQAICSMGINLFRVLMTYLKPVLPKL 499

  Fly   496 ANRLLDKLSVPTAQRGWNYLAESFATSPNSSNSPAGLGESRQLDGQTSAL----------LFQRI 550
            ..|                 ||:|            |......||....|          |:.||
E. coli   500 TER-----------------AEAF------------LNTELTWDGIQQPLLGHKVNPFKALYNRI 535

  Fly   551 -------LEETSAKEVK 560
                   |.|.|.:|||
E. coli   536 DMRQVEALVEASKEEVK 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_650348.1	MetG	21..559	CDD:439913	139/599 (23%)
metG	NP_416617.1	metG	6..677	CDD:234655	142/602 (24%)