DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS-m and MARS2

DIOPT Version :9

Sequence 1:	NP_001262564.1	Gene:	MetRS-m / 41733	FlyBaseID:	FBgn0027083	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_612404.1	Gene:	MARS2 / 92935	HGNCID:	25133	Length:	593	Species:	Homo sapiens

Alignment Length:	578	Identity:	260/578 - (44%)
Similarity:	353/578 - (61%)	Gaps:	46/578 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RIKCLRYLGTRYNSS-------------HYVTTPIFYVNAAPHIGHLYSAVIADAHCRYQRLRYP 56
            |:..|...|.||.||             .|.|||||||||||||||||||::|||.||::|||.|
Human    17 RLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRGP 81

  Fly    57 E-QDVRLCTGTDEHGTKIQQAASLHGVPVAKYCDDISQRYREVFRSASIQQDDFIRTTEDRHKRA 120
            . ...|..|||||||.||||||:..|:...:.||.:|::::::|:.|.|...|||||||.||:.|
Human    82 STAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVA 146

  Fly   121 VANFWRTLHTRGHIYSAAYSGWYCVSDETFLTDSQLRLDEA-TGTRY--SLESGHPVEWTEETNY 182
            |.:||..|.:||.:|...|.||||.|||.||.::::..... :|..:  ||||||||.||:|.||
Human   147 VQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEAKVTQQPGPSGDSFPVSLESGHPVSWTKEENY 211

  Fly   183 MFRLSQFQDDVRHWVKTEAR-VRPAKFEKILLDTLSEPLPDVSVSRPSNRVHWAIPVPDDDSQTV 246
            :||||||:..::.|::...: :.|..|..::|..|.|.|||:||||.|:.:||.||||.|||||:
Human   212 IFRLSQFRKPLQRWLRGNPQAITPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTI 276

  Fly   247 YVWLDALVNYLSSVGYPDEKFSAHWPPAQQVIGKDILKFHGIYWTAFLLAAGLEPPGQLYVHSHW 311
            |||||||||||:.:|||:.:|.:.||....:|||||||||.|||.||||.||:.||.::.|||||
Human   277 YVWLDALVNYLTVIGYPNAEFKSWWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHW 341

  Fly   312 TVDGQKMSKSKHNVVDPLQAAQQYTMEGLRYFLLREGVAHSDGNYSHVKAQRILNSELADTLGNL 376
            ||.|||||||..|||||.....:||::|.||||||:||.:.|.:|...|..::|||||||.||.|
Human   342 TVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGL 406

  Fly   377 LSRASAKSLNPGQIYPS--------------PSAEHLADLLRSLDVAKRLQDSLLQLSERCESHY 427
            |:|.:||.:||.:.||:              ||....|:     |.|  |..::..|.::...||
Human   407 LNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAE-----DYA--LVSAVATLPKQVADHY 464

  Fly   428 ECNHFHLVADTTMAALHAANNFFESSKPWTLKAGAPDGNQARLETIIAMTMDALRLSGIVLQPII 492
            :....:...:...:.:...|.|.:...||.|...:| .:...|.|::.:.::.||:.|.:|||:.
Human   465 DNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESP-VDAPWLGTVLHVALECLRVFGTLLQPVT 528

  Fly   493 PQLANRLLDKLSVPTAQRGWNYLAESFATSPNSSNSPAGLGESRQLDGQTSALLFQRI 550
            |.||::||.:|.|..::|.   |.|.:.. |.....|... |.|:| |..:.|||.|:
Human   529 PSLADKLLSRLGVSASERS---LGELYFL-PRFYGHPCPF-EGRRL-GPETGLLFPRL 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_001262564.1	MetRS_core	20..356	CDD:173907	190/340 (56%)
		PRK11893	21..553	CDD:237012	253/549 (46%)
		Anticodon_Ia_like	365..503	CDD:299868	46/151 (30%)
MARS2	NP_612404.1	PRK11893	46..581	CDD:237012	253/549 (46%)
		'HIGH' region	52..62		9/9 (100%)
		'KMSKS' region	347..351		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158748
Domainoid	1	1.000	422	1.000	Domainoid score	I626
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6009
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1487
Isobase	1	0.950	-	0	Normalized mean entropy	S1506
OMA	1	1.010	-	-		QHG54021
OrthoDB	1	1.010	-	-		D334822at33208
OrthoFinder	1	1.000	-	-		FOG0005001
OrthoInspector	1	1.000	-	-		oto88659
orthoMCL	1	0.900	-	-		OOG6_101119
Panther	1	1.100	-	-	LDO	PTHR43326
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1450
SonicParanoid	1	1.000	-	-		X3534
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750