Protein Alignment MetRS-m and MES1

DIOPT Version :10

• Sequence 1: NP_650348.1
• Gene: MetRS-m / 41733
• FlyBaseID: FBgn0027083
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_011780.3
• Gene: MES1 / 853181
• SGDID: S000003496
• Length: 751
• Species: Saccharomyces cerevisiae
• Alignment Length: 611
• Identity: 132/611 - (21%)
• Similarity: 236/611 - (38%)
• Gaps: 140/611 - (22%)

  Fly    22 VTTPIFYVNAAPHIGHLYSAVI-ADAHCRYQRLRYPEQDVRLCTGTDEHGTKIQQAASLHGVPVA 85
            :|:.:.|||..||:|::..:|: ||...||.:.|  ..:.....||||:||..:..|...||...
Yeast   200 ITSALPYVNNVPHLGNIIGSVLSADIFARYCKGR--NYNALFICGTDEYGTATETKALEEGVTPR 262

  Fly    86 KYCDDISQRYREVFRSASIQQDDFIRTTEDRHKRAVANFWRTLHTRGHIYSAAYSGWYCVSDETF 150
            :.||...:.:.:|::...|..|.|.|||.|:......:.:..|::.|::...:....||....::
Yeast   263 QLCDKYHKIHSDVYKWFQIGFDYFGRTTTDKQTEIAQHIFTKLNSNGYLEEQSMKQLYCPVHNSY 327

  Fly   151 LTD-------SQLRLDEATG-----------------TRYSLESGHPVEWTEETNY----MFRLS 187
            |.|       .:...|:|.|                 .|..|:...|     |..|    ...|.
Yeast   328 LADRYVEGECPKCHYDDARGDQCDKCGALLDPFELINPRCKLDDASP-----EPKYSDHIFLSLD 387

  Fly   188 QFQDDVRHWV-KTEARVRPAKFEKILLDT-LSEPLPDVSVSRPSNRVHWAIPVPDD--DSQTVYV 248
            :.:..:..|| |.......:|..|.:..: |.:.|....::|.   :.|..|||.:  ..:.:||
Yeast   388 KLESQISEWVEKASEEGNWSKNSKTITQSWLKDGLKPRCITRD---LVWGTPVPLEKYKDKVLYV 449

  Fly   249 WLDALVNYLSSVGYPDEKFSAHWPPAQ-----QVIGKDILKFHGIYWTAFLLAAGLEPPGQLYVH 308
            |.||.:.|:|......:::...|...:     |.:|||.:.||.:.:          |..||...
Yeast   450 WFDATIGYVSITSNYTKEWKQWWNNPEHVSLYQFMGKDNVPFHTVVF----------PGSQLGTE 504

  Fly   309 SHWTV------------DGQKMSKSK------HNVVDPLQAAQQYTMEGL-----RYFLLREGVA 350
            .:||:            :..|.|||:      :|..|          .|:     ||:|......
Yeast   505 ENWTMLHHLNTTEYLQYENGKFSKSRGVGVFGNNAQD----------SGISPSVWRYYLASVRPE 559

  Fly   351 HSDGNYSHVKAQRILNSELADTLGNLLSRASAKSLNP--GQIYPSPSAEHLADLLRSLDVAKRLQ 413
            .||.::|........||||...|||.::|. .|.:|.  ..:.|....:.:::           .
Yeast   560 SSDSHFSWDDFVARNNSELLANLGNFVNRL-IKFVNAKYNGVVPKFDPKKVSN-----------Y 612

  Fly   414 DSLLQLSERCESHY----ECNHFHLVADTTMAALHAANNFFESSK-PWTLKAGAPDGNQARLETI 473
            |.|::......|:|    |..|.....:..|:.....|.|.:.:| ..||.:.:|:.:.|    :
Yeast   613 DGLVKDINEILSNYVKEMELGHERRGLEIAMSLSARGNQFLQENKLDNTLFSQSPEKSDA----V 673

  Fly   474 IAMTMDALRLSGIVLQPIIPQLANRLLDKLSVPTAQRGWNYLAESFATSPNSSNSPAGLGESRQL 538
            :|:.::.:.....::.|.:|::..::...|:.|..:     :.:.|..:              .|
Yeast   674 VAVGLNIIYAVSSIITPYMPEIGEKINKMLNAPALK-----IDDRFHLA--------------IL 719

  Fly   539 DGQT---SALLFQRI----LEETSAK 557
            :|..   :..|||||    ::|..||
Yeast   720 EGHNINKAEYLFQRIDEKKIDEWRAK 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_650348.1	MetG	21..559	CDD:439913	132/611 (22%)
MES1	NP_011780.3	MetRS-N	11..132	CDD:401537
		PLN02610	190..>750	CDD:215329	132/611 (22%)