DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS-m and MSM1

DIOPT Version :9

Sequence 1:	NP_001262564.1	Gene:	MetRS-m / 41733	FlyBaseID:	FBgn0027083	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_011687.1	Gene:	MSM1 / 853081	SGDID:	S000003403	Length:	575	Species:	Saccharomyces cerevisiae

Alignment Length:	630	Identity:	209/630 - (33%)
Similarity:	295/630 - (46%)	Gaps:	111/630 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKCLRYLGTRYNSSHYVTTPIFYVNAAPHIGHLYSAVIADAHCRYQ----RLRYPEQDVRLCTGT 66
            ::|...:...|:...:|||||||.||.||:|||||::::|.:.|:|    .|.:      ..|||
Yeast     1 MQCRSIVHRLYSKVSHVTTPIFYPNAKPHLGHLYSSLLSDVYHRWQLFKGNLSF------FTTGT 59

  Fly    67 DEHGTKIQQAASLHGV-PVAKYCDDISQRYREVFRSASIQQDDFIRTTEDRHKRAVANFWRTLHT 130
            ||||.|||.|:..:|. ...|:.|.:...:.::.:...|....|||||:..|...|...|.....
Yeast    60 DEHGLKIQCASESNGFDQPKKFVDKLYPEFVQLDKIYGINYTRFIRTTDPDHIENVMKLWELCLK 124

  Fly   131 RGHIYSAAYSGWYCVSDETFLTDSQLRLDEATGTRY-SLESGHPVEWTEETNYMFRLSQFQDD-V 193
            .|:||...:.|||.:|||||..:|::..|.....:| :.||.:.|.:..||||.||||.|... |
Yeast   125 NGYIYMGEHKGWYSISDETFYPESKVIKDPKNDGKYLNTESKNEVVYQSETNYFFRLSLFNKKIV 189

  Fly   194 RHWVKTEARVRPA-KFEKIL--LDTLSEPLPDVSVSRPSNRVHWAIPVPDDDSQTVYVWLDALVN 255
            .|..|....:.|| |.::||  |:| ...|||:|:||||.|:.|.||.|:|.||.||||.|||.|
Yeast   190 DHIRKNPDFIFPASKRDQILKELET-GGTLPDLSISRPSARLKWGIPTPNDPSQKVYVWFDALCN 253

  Fly   256 YLSSV-GYPD------EKFSAH--------------WPPAQQ-----VIGKDILKFHGIYWTAFL 294
            ||||: |.|.      |..|.|              :|...|     ||||||.|||.:||.:||
Yeast   254 YLSSIGGIPSILSNATEVVSRHYSDKSNVKGQLLIPYPKEVQRNTIHVIGKDIAKFHTVYWPSFL 318

  Fly   295 LAAGLEPPGQLYVHSHWTVDGQKMSKSKHNVVDPLQAAQQYTMEGLRYFLLREGVAHSDGNYSHV 359
            |||||..|.|:.||.||..:|.|||||..|||||:..|:.|..:.:|:|||.......||::...
Yeast   319 LAAGLPLPRQIVVHGHWLCNGMKMSKSLGNVVDPIDMARYYGADIVRWFLLENSKLEEDGDFQEA 383

  Fly   360 KAQRILNSELADTLGNLLSRASAKSLNPGQIYPSPSAEHLADLLRSLDVAKRLQDSLLQ----LS 420
            |... ....|....|||::|......|..:.           :::..|.|......:.|    :|
Yeast   384 KLYE-TRELLVSKWGNLINRCCGSKFNIERA-----------VMKFSDKANFQFQEIFQNEPIVS 436

  Fly   421 ERCESHYE-CNHFHLVADTTMA-------------ALHAANNFFESSKPWTLKAGAPDGNQARLE 471
            ||.|:..: .|....|.|..:|             .::.||...::||||..:....|
Yeast   437 ERIENLAKLLNKSQEVFDEKIAIFQYPQLLRHVWSIINDANTLVQNSKPWERELDQQD------- 494

  Fly   472 TIIAMTMDALRLSGIVLQPIIPQLANRLLDKLSVPTAQRGWNYLAESFATSPNSSNSPAGLGESR 536
            .||.:.|:..|:..|:.|.|||.|:...||::.|...:|..||               |.||..:
Yeast   495 NIIFLAMETSRILSILCQSIIPSLSQSFLDRIDVSKEKRTINY---------------ARLGSDK 544

  Fly   537 QLDGQTSALLFQRILEETSAKEVKEQKPQPAKRSKSKKKERRETM 581
            ....|::                |:.:..|.|:...:.:|.:..|
Yeast   545 TYGKQSN----------------KKGREVPLKKIPFRLQEEQTNM 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_001262564.1	MetRS_core	20..356	CDD:173907	157/371 (42%)
		PRK11893	21..553	CDD:237012	202/585 (35%)
		Anticodon_Ia_like	365..503	CDD:299868	36/155 (23%)
MSM1	NP_011687.1	metG	15..550	CDD:273058	201/575 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346056
Domainoid	1	1.000	255	1.000	Domainoid score	I324
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6009
Inparanoid	1	1.050	286	1.000	Inparanoid score	I541
Isobase	1	0.950	-	0	Normalized mean entropy	S1506
OMA	1	1.010	-	-		QHG54021
OrthoFinder	1	1.000	-	-		FOG0005001
OrthoInspector	1	1.000	-	-		oto99089
orthoMCL	1	0.900	-	-		OOG6_101119
Panther	1	1.100	-	-	LDO	PTHR43326
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1450
SonicParanoid	1	1.000	-	-		X3534
TreeFam	1	0.960	-	-
	16	15.740