DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MetRS-m and mars2

DIOPT Version :9

Sequence 1:	NP_001262564.1	Gene:	MetRS-m / 41733	FlyBaseID:	FBgn0027083	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_021329980.1	Gene:	mars2 / 566565	ZFINID:	ZDB-GENE-111201-1	Length:	595	Species:	Danio rerio

Alignment Length:	568	Identity:	257/568 - (45%)
Similarity:	351/568 - (61%)	Gaps:	32/568 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SHYVTTPIFYVNAAPHIGHLYSAVIADAHCRYQRL-RYPEQDVRLCTGTDEHGTKIQQAASLHGV 82
            ::|:|||||||||.|||||:||||.||...||:.| ||   :.|..|||||||.||||||...|.
Zfish    46 AYYITTPIFYVNAPPHIGHVYSAVTADCLHRYKLLQRY---NSRFATGTDEHGLKIQQAAGSAGK 107

  Fly    83 PVAKYCDDISQRYREVFRSASIQQDDFIRTTEDRHKRAVANFWRTLHTRGHIYSAAYSGWYCVSD 147
            ....:|.::|:.::.||:...|...|:|||||.||::||.:||..|.::.:||...|.|||...|
Zfish   108 DPLNFCTEVSESFKHVFQRCGISYTDYIRTTEKRHRQAVEHFWTVLQSKSYIYKGTYEGWYSTPD 172

  Fly   148 ETFLTDSQLR-LDEATGTR--YSLESGHPVEWTEETNYMFRLSQFQDDVRHWVKTEAR-VRPAKF 208
            |:|||::|:. ..::.|.|  .|.||||.|||..|.|||||||.|...:.||:::... ::|.||
Zfish   173 ESFLTETQVTDSTDSEGRRIKVSTESGHKVEWMNEDNYMFRLSDFHTQLLHWLRSNPNTIQPVKF 237

  Fly   209 EKILLDTL-SEPLPDVSVSRPSNRVHWAIPVPDDDSQTVYVWLDALVNYLSSVGYPDEKFSAHWP 272
            :.::|..| .:.:||:||||..:|:.|.||||.|..||:|||||||||||:.|||| :..|..|.
Zfish   238 QHLVLQWLEDDDIPDLSVSRQKSRLQWGIPVPGDPEQTIYVWLDALVNYLTVVGYP-QNHSKWWS 301

  Fly   273 PAQQVIGKDILKFHGIYWTAFLLAAGLEPPGQLYVHSHWTVDGQKMSKSKHNVVDPLQAAQQYTM 337
            ....|:||||||||.|||.||||||||..|.::||||||||:|:|||||..||::||::.:::|:
Zfish   302 VVHHVVGKDILKFHAIYWPAFLLAAGLALPQKIYVHSHWTVEGKKMSKSIGNVINPLESIEKFTV 366

  Fly   338 EGLRYFLLREGVAHSDGNYSHVKAQRILNSELADTLGNLLSRASAKSLNPGQIYPSPS-----AE 397
            :||||||||:||..||.:|...|..::.||||||.||.||:|.:|.|||..|:||..|     |.
Zfish   367 DGLRYFLLRQGVPDSDCDYYDDKVMKMCNSELADALGGLLNRCTAPSLNLTQVYPRFSNSCFPAV 431

  Fly   398 HLADLLRSLDVAKRLQDSLLQLSERCESHYECNHFHLVADTTMAALHAANNFFESSKPWTLKAGA 462
            .|:....|.|.  |:.:::..|....|.|:|..|.:...:...|.:...|.|.:...||.|....
Zfish   432 GLSGKAVSEDY--RMIEAVSALPGIIEQHFENMHVYKALEAIGACVRLTNGFVQRHAPWKLDRNN 494

  Fly   463 PDGNQARLETIIAMTMDALRLSGIVLQPIIPQLANRLLDKLSVPTAQRGWNYLAESFATSPNSSN 527
            |: .|..|:||:.::::.||:.||:|||::|.||:::|.:|.|...:|.||.|        |..|
Zfish   495 PE-EQQWLDTILHVSLECLRIYGILLQPVVPDLADKILSRLGVTPEERSWNSL--------NFLN 550

  Fly   528 SPAGLG---ESRQLDGQTSALLFQRILEETSAKEVKEQKPQPAKRSKS 572
            ...|..   |.|.| |....:||.|:  |.|..:.|..|.....:|||
Zfish   551 KFQGRECALEGRAL-GPDLGVLFSRL--ERSQIKGKTTKKGTQPKSKS 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_001262564.1	MetRS_core	20..356	CDD:173907	181/341 (53%)
		PRK11893	21..553	CDD:237012	250/545 (46%)
		Anticodon_Ia_like	365..503	CDD:299868	51/142 (36%)
mars2	XP_021329980.1	PRK12267	45..594	CDD:330948	254/565 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594702
Domainoid	1	1.000	391	1.000	Domainoid score	I750
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6009
Inparanoid	1	1.050	461	1.000	Inparanoid score	I1535
OMA	1	1.010	-	-		QHG54021
OrthoDB	1	1.010	-	-		D334822at33208
OrthoFinder	1	1.000	-	-		FOG0005001
OrthoInspector	1	1.000	-	-		oto39190
orthoMCL	1	0.900	-	-		OOG6_101119
Panther	1	1.100	-	-	LDO	PTHR43326
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1450
SonicParanoid	1	1.000	-	-		X3534
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800