DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS-m and ValRS

DIOPT Version :9

Sequence 1:	NP_001262564.1	Gene:	MetRS-m / 41733	FlyBaseID:	FBgn0027083	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster

Alignment Length:	797	Identity:	143/797 - (17%)
Similarity:	240/797 - (30%)	Gaps:	318/797 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NSSHYVTTPIFYVNAAPHIGHLYSAVIADAHCRYQRLRYPEQDVRLCTGTDEHGTKIQ------- 74
            |....:..|...|..:.|:||..:..|.||..||.|::  .:......|.|..|...|
  Fly   128 NGKFVMIIPPPNVTGSLHLGHALTNAIEDAITRYHRMK--GRTTLWVPGCDHAGIATQVVVEKLL 190

  Fly    75 ---QAASLHGVPVAKYCDDISQRYREVFRSASIQQD--------DFIR---TTEDRHKRAVANFW 125
               :..|.|.:...|:.:.|....||  :...|.:.        |:.|   |.:.:..|||...:
  Fly   191 WRDEKLSRHDLGREKFIERIWDWRRE--KGGRIYEQLKSLGSSYDWTRVAFTMDPKLCRAVTEAF 253

  Fly   126 RTLHTRGHIY-SAAYSGWYC-----VSD----------ETFL----------------------- 151
            ..||..|.|| |:....|.|     :||          .|||
  Fly   254 VRLHEEGSIYRSSRLVNWSCTLRSAISDIEVDKVEIPGRTFLSIPGYEDKVEFGVLIKFAYKVEG 318

  Fly   152 TDSQL-----RLDEATG----------TRYSLESG----HP------------------------ 173
            :|.::     |::...|          .||....|    ||
  Fly   319 SDEEIIVATTRIETMLGDTAVAVHPQDDRYKHLHGKFVVHPFSTRRLPIVCDEFVDMAFGTGAVK 383

  Fly   174 ---------VEWTEETNYMFRLSQFQDD------------VRHWVKTEARVRPAKFEKILLDTLS 217
                     .|..:..|..| ::.|.||            ::.:...:..:...|...:..:||:
  Fly   384 ITPAHDPNDYEVGKRCNLPF-ITIFNDDGYIIGDYGEFTGMKRFECRKKILEKLKALNLYRETLN 447

  Fly   218 EPL--PDVSVSR----PSNRVHWAIP-------------------VPDDDSQTVYVWLDALVNY- 256
            .|:  |..|.|:    |..:..|.:.                   :|:..::|.|.|:|.:.::
  Fly   448 NPMVVPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSGELKIIPEHHTKTWYHWMDGIRDWC 512

  Fly   257 ----------------------------------------------------------------- 256

  Fly   513 VSRQLWWGHRIPAYHVSFTDPSLQTGSSAHGSVNDDEQYWIVARSEAEALTKAAERFGVDASKIV 577

  Fly   257 ------------------LSSVGYPDE--KFSAHWPPAQQVIGKDILKFHGIYWTAFLLAAGLEP 301
                              .|..|:||:  .....:|.:....|.|||    .:|.|.::..|.:.
  Fly   578 LKQDEDVLDTWFSSGIFPFSVFGWPDQTKDLQTFYPTSLLETGHDIL----FFWVARMVFFGQKL 638

  Fly   302 PGQL-----YVH-----SHWTVDGQKMSKSKHNVVDPLQAAQQYTMEGLRYFL---------LRE 347
            .|:|     |:|     :|    |:|||||..||:||:...:..|:|||...|         :.:
  Fly   639 LGKLPFKEVYLHPMVRDAH----GRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEK 699

  Fly   348 GVAHSDGNY-----------------SHVKAQRILNSELADTLG-----NLLSRASAKSLNPGQI 390
            ..|....:|                 :::...|.:|.::...||     |.|..|:..:|    :
  Fly   700 AKAGQKQDYPQGIPECGSDALRFALCAYITQARDINLDINRVLGYRFFCNKLWNATKFAL----L 760

  Fly   391 YPSPSAEHLADL-----LRSLD--VAKRLQDSLLQLSERCESHYECNHFHLVADTTMA--ALHAA 446
            |.:.|.:...:|     :..:|  :..||..::    |.|.:.:|...|........|  .....
  Fly   761 YFTGSEKFDTELSASAAINQMDAWILSRLAAAI----EACNTGFESYDFAAATSACYAFWLYDLC 821

  Fly   447 NNFFESSKPWTLKAGAPDGNQARLETIIAMTMDALRLSGIVLQPIIPQLANRLLDKLSVPTAQRG 511
            :.:.|..|| ..::|:.:...|...|:.......|||    |.|.:|.:...|..:|  |.|..
  Fly   822 DVYLECLKP-IFQSGSEEQQTAARRTLYVCLDYGLRL----LSPFMPFITEELYQRL--PRANP- 878

  Fly   512 WNYLAESFATSPNSSNS 528
                |.|...:...||:
  Fly   879 ----APSICVASYPSNT 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_001262564.1	MetRS_core	20..356	CDD:173907	102/589 (17%)
		PRK11893	21..553	CDD:237012	142/793 (18%)
		Anticodon_Ia_like	365..503	CDD:299868	31/151 (21%)
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	143/797 (18%)
		ValRS_core	129..736	CDD:185677	104/619 (17%)
		tRNA-synt_1_2	307..436	CDD:290334	14/129 (11%)
		Anticodon_Ia_Val	736..873	CDD:153416	30/149 (20%)
		Val_tRNA-synt_C	978..1053	CDD:287436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840