DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS-m and LeuRS-m

DIOPT Version :9

Sequence 1:	NP_001262564.1	Gene:	MetRS-m / 41733	FlyBaseID:	FBgn0027083	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_647932.1	Gene:	LeuRS-m / 38581	FlyBaseID:	FBgn0027085	Length:	869	Species:	Drosophila melanogaster

Alignment Length:	748	Identity:	135/748 - (18%)
Similarity:	229/748 - (30%)	Gaps:	302/748 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GTRYN-----SSHYVTTPIFYVNAAPHIGHLYSAVIADAHCRYQRLRYPEQDVRLCTGTDEHGTK 72
            |.::|     ..:||.:...|.:...|:||:....|||:..|:||:  ..::|....|.|..|..
  Fly    52 GGQFNPKDSQDKYYVLSMFPYPSGNLHMGHVRVYTIADSVARFQRM--CGKNVFQPMGWDSFGLP 114

  Fly    73 IQQAASLHGVPVAKYCD-DISQRYREVFR-SASIQQDDFIRTTEDRHKRAVANFWRTLHTRGHIY 135
            .:.||:..||..|.:.: :|:|...::.| ..|...:..:.|...::.:...:.:..||..|..|
  Fly   115 AENAANQRGVEPASWTEQNIAQMKEQLKRLGCSFDWNHELSTCSPKYYKWTQHLFLMLHRHGLAY 179

  Fly   136 -SAAYSGWYCVSDETFLTDSQLRLDEATGTRYSLESGHPVE------WTEETNYMFR-------- 185
             :.|...|..| |:|.|.|.|:   :|.|.  |..||..||      |...|:...:
  Fly   180 QNEALVNWDPV-DKTVLADEQV---DANGC--SWRSGAKVEKKLLRQWFIRTSAYAKQLLDGLED 238

  Fly   186 --LSQFQDDV---RHWV------------------------------------------------ 197
              |..::|.:   |||:
  Fly   239 PTLRDWRDIINLQRHWIGECDGYAFNLLTSASGLLRVWTTHPEHLKDPHAFLVLRSNHHLSKLKG 303

  Fly   198 ---------------------------------------------------------KTEARVRP 205
                                                                     |.|..:.|
  Fly   304 ADSLSAANPFAGTTMPVVFSDEVTFPPKSDVYLAAPSFRGEDKDLWDSYGLAFTSNGKDEESLSP 368

  Fly   206 AKFEKILLDTL-------------SEPLPDVSVSR------PSNRVH----WAIPVPDD------ 241
            |.:|.:..:.|             |..|.|..:||      |...||    .|:|||::
  Fly   369 ANWEMLRKEVLQAATRLNVGGYRVSSKLKDWLISRQRYWGTPIPIVHCQKCGAVPVPEEQLPVSL 433

  Fly   242 ------------------------DSQTVYVWLDALVNYL------SSVGYPDEKFSAHWPPAQQ 276
                                    ::.|:..::|:...||      :|....|...:..:.|...
  Fly   434 PPKDSPKEAFLCDCPKCGEKDARRETDTMDTFVDSSWYYLRYLDAQNSERIFDTALTKKFMPVDL 498

  Fly   277 VI-GKDILKFHGIYWTA----FLLAAGLEPPGQLYVHSHWTVDG--------------------- 315
            .| ||:....| :|:..    ||.:.||.|..:.:  |...|.|
  Fly   499 YIGGKEHAVLH-LYYARFINHFLHSCGLSPTSEPF--SRLLVQGMVMGRSFRVKGSGRYVPETEV 560

  Fly   316 -----------------------QKMSKSKHNVVDPLQAAQQYTMEGLRYFLLREGVAHSDGNYS 357
                                   :||||||.|.|:|.....:|..:..|..:|.:....|..|:|
  Fly   561 EIVNAKKNQAVLKETKEPVVMTWEKMSKSKLNGVEPSDMFNEYGTDTTRLIILADVAPTSHRNWS 625

  Fly   358 HVKAQRILN--SELADTLGNLLSRASAKSLNPGQIYPSPSAEHLADLLRSLDVAKRLQDSLLQLS 420
            ......|||  ..|..||.:.  :.:.:......:.|: |.|.||            :|:.|
  Fly   626 SATFPGILNWQKRLWLTLQDF--QQAREDQTASDVVPT-SEEFLA------------EDAKL--- 672

  Fly   421 ERCESHYECNHFHLVADT-----------TMAALHAANNFFESSKPWTLKAGAPDGNQARLETII 474
                  ::..:|::...|           .::.:....|....:....|:.|      .:.|..:
  Fly   673 ------FDARNFYVKGATFNYRHAQQLSVAISKMQGLTNSLRRTPKHVLRHG------KQFERAL 725

  Fly   475 AMTMDALRLSGIVLQPIIPQLANRLLDK-LSVP 506
            |..:       |:|.|:.|..|:.|..| :::|
  Fly   726 AAQI-------IMLAPMAPHFASELWSKFVAIP 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_001262564.1	MetRS_core	20..356	CDD:173907	103/570 (18%)
		PRK11893	21..553	CDD:237012	133/735 (18%)
		Anticodon_Ia_like	365..503	CDD:299868	26/151 (17%)
LeuRS-m	NP_647932.1	leuS	40..848	CDD:234743	135/748 (18%)
		LeuRS_core	63..624	CDD:173906	103/571 (18%)
		Anticodon_Ia_like	624..747	CDD:299868	27/159 (17%)
		Anticodon_Ia_like	<723..799	CDD:299868	9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446767
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840