DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS-m and MetRS

DIOPT Version :9

Sequence 1:	NP_001262564.1	Gene:	MetRS-m / 41733	FlyBaseID:	FBgn0027083	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_611382.1	Gene:	MetRS / 37177	FlyBaseID:	FBgn0034401	Length:	1022	Species:	Drosophila melanogaster

Alignment Length:	621	Identity:	146/621 - (23%)
Similarity:	236/621 - (38%)	Gaps:	127/621 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VTTPIFYVNAAPHIGHLYSAVI-ADAHCRYQRLRYPEQDVRLCTGTDEHGTKIQQAASLHGVPVA 85
            :|:.:.|||..||:|::...|: ||.:.||.  |....:..|..||||:||..:..|....:...
  Fly   258 ITSALPYVNNVPHLGNIIGCVLSADIYARYS--RSAGYNTLLICGTDEYGTATENKALAENLTPR 320

  Fly    86 KYCDDISQRYREVFRSASIQQDDFIRTTEDRHKRAVANFWRTLHTRGHIYSAAYSGWYCVSDETF 150
            :.||...:.:..::|...|..|.|.|||.......|...::.:...|:|.:.:.....|...:.|
  Fly   321 EICDKYFELHNAIYRWFGIGFDYFGRTTTQEQTDIVQEAFKDVLKAGYIITESVEQLLCQKCDRF 385

  Fly   151 LTDSQLR---------LDEATGTRYSLESGHPVEWTE----------------ETNYMF-RLSQF 189
            |.|..:.         .::|.|.:.. :.|..|..||                .::.:| .|.:.
  Fly   386 LADRFVEGTCPHPGCGYEDARGDQCD-KCGKLVNATELIRPRCKVCNSAPVLRSSDQLFIDLPKA 449

  Fly   190 QDDVRHWV-KTE------ARVRPAKFEKILLDTLSEPLPDVSVSRPSNRVHWAIPVPDD--DSQT 245
            :..::.|| |:|      |:|       |....|.|.|....::|.   :.|.||||.:  :.:.
  Fly   450 EPQLKEWVDKSEGGWTHNAKV-------ITRAWLKEGLKPRCITRD---LKWGIPVPHEGFEKKV 504

  Fly   246 VYVWLDALVNYLSSVGYPDEKFSAHWPPAQ-------QVIGKDILKFHGIYWTAFLLA--AGLEP 301
            .|||.||...|:|......:::...|.||:       |.:.||.:.||.:.|.:.|||  .|...
  Fly   505 FYVWFDAPFGYVSMTKRYTKEYQQWWQPAKGTDVELFQFMAKDNVPFHSVVWPSVLLAINKGHTL 569

  Fly   302 PGQLYVHSHWTVDGQKMSKSKHNVVDPLQAAQQYTMEGL-----RYFLLREGVAHSDGNYSHVKA 361
            ...:....:...:..|.|||:...|....|.:    .|:     |::|........|.::|....
  Fly   570 VSHIMATEYLNYEDGKFSKSRGIGVFGNDAQE----TGIPADVWRFYLASARPEGQDSSFSWNDL 630

  Fly   362 QRILNSELADTLGNLLSRA------SAKSLNPGQIYPSPSA-------EHLADLLRSLDVAKRLQ 413
            ....||||.:.|||.::||      :..|..||.|......       ..|...:.|::.|| |:
  Fly   631 AARNNSELLNNLGNFVNRALVFCEKNFSSTVPGVITTQDELVLLALINRELRGYINSMEKAK-LR 694

  Fly   414 DSLLQLSERCESHYECNHFHLVADTTMAALHAANNFFESSKPWTLKAGAPDGNQARLETIIAMTM 478
            |.:..|                    :|.....|.:.:|.:||.|..|. |..:.|..|||.:.:
  Fly   695 DGVRHL--------------------LAISRHGNGYMQSQQPWVLLKGT-DDQKTRASTIIGLCV 738

  Fly   479 DALRLSGIVLQPIIPQLANRLLDKLSVPTAQRGWNYLAESFATSPNSSNS------PAG--LGES 535
            :...|...:|.|.:|..|..|..:|:..             .|..|:...      |||  :|:.
  Fly   739 NIACLLANLLFPYMPTTARTLFGQLNAK-------------QTPLNAEKPLVTLLLPAGHQIGKP 790

  Fly   536 RQLDGQTSALLFQRILEETSAKEVKEQKPQPAKRSK 571
            ..|    .|.|.|..::|...|....|....|..|:
  Fly   791 APL----FAKLEQSFIDELKGKYGGAQATNDAAHSQ 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_001262564.1	MetRS_core	20..356	CDD:173907	91/383 (24%)
		PRK11893	21..553	CDD:237012	141/601 (23%)
		Anticodon_Ia_like	365..503	CDD:299868	38/150 (25%)
MetRS	NP_611382.1	GstA	1..175	CDD:223698
		GST_N_family	1..65	CDD:238319
		GST_C_family	63..164	CDD:295467
		PRK12268	254..812	CDD:237029	143/609 (23%)
		MetRS_core	255..625	CDD:173907	91/383 (24%)
		Anticodon_Ia_Met	634..763	CDD:153411	38/150 (25%)
		MetRS_RNA	828..868	CDD:238475
		MetRS_RNA	895..938	CDD:238475
		MetRS_RNA	966..1009	CDD:238475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0143
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740