DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MetRS-m and Mars2

DIOPT Version :9

Sequence 1:	NP_001262564.1	Gene:	MetRS-m / 41733	FlyBaseID:	FBgn0027083	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_780648.1	Gene:	Mars2 / 212679	MGIID:	2444136	Length:	586	Species:	Mus musculus

Alignment Length:	584	Identity:	266/584 - (45%)
Similarity:	350/584 - (59%)	Gaps:	45/584 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CLRY-------LGTRYNSSHYVTTPIFYVNAAPHIGHLYSAVIADAHCRYQRLRYP-EQDVRLCT 64
            |.||       .|....:..|.|||||||||||||||||||::|||.||::|||.| ....|..|
Mouse    19 CRRYGSCSPSASGDAGEARAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRVPGSASTRFST 83

  Fly    65 GTDEHGTKIQQAASLHGVPVAKYCDDISQRYREVFRSASIQQDDFIRTTEDRHKRAVANFWRTLH 129
            ||||||.||||||:..|:...:.||.:|.::.::||.|.|...|||||||.||:.||.:||..|.
Mouse    84 GTDEHGLKIQQAAATAGLAPIELCDRVSAQFLQLFREADISSTDFIRTTEARHRVAVQHFWGVLE 148

  Fly   130 TRGHIYSAAYSGWYCVSDETFLTDSQLRLDEATGTR----------YSLESGHPVEWTEETNYMF 184
            .||.:|...|.||||.|||.|       |.||..||          .||||||||.||:|.||:|
Mouse   149 ARGLLYKGIYEGWYCASDECF-------LPEAKVTRQVGPSGDPCPVSLESGHPVSWTKEENYIF 206

  Fly   185 RLSQFQDDVRHWVKTEAR-VRPAKFEKILLDTLSEPLPDVSVSRPSNRVHWAIPVPDDDSQTVYV 248
            :||||::.::.|:....: :.|..|.:.:|..|.|.|||:||||.|:.:||.||||.|||||:||
Mouse   207 KLSQFREPLQRWLGNNPQAITPEPFHQAVLQWLEEELPDLSVSRRSSHLHWGIPVPGDDSQTIYV 271

  Fly   249 WLDALVNYLSSVGYPDEKFSAHWPPAQQVIGKDILKFHGIYWTAFLLAAGLEPPGQLYVHSHWTV 313
            |||||||||:.|||||..|.:.||....:|||||||||.|||.|.||.|||.||.::||||||||
Mouse   272 WLDALVNYLTVVGYPDADFKSWWPATSHIIGKDILKFHAIYWPALLLGAGLRPPHRIYVHSHWTV 336

  Fly   314 DGQKMSKSKHNVVDPLQAAQQYTMEGLRYFLLREGVAHSDGNYSHVKAQRILNSELADTLGNLLS 378
            .|||||||..|||||.....:||::|.||||||:||.:.|.:|...|..::|:|||||.||.||:
Mouse   337 SGQKMSKSLGNVVDPRTCLDRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLDSELADALGGLLN 401

  Fly   379 RASAKSLNPGQIYPS------PSAEHLAD---LLRSLDVAKRLQDSLLQLSERCESHYECNHFHL 434
            |.:|..:||...|||      ||...|..   .:::.|.|  |..::..|.:....:|.....:.
Mouse   402 RCTAYRINPSGTYPSFCAACFPSEPGLTGPSVRVQAEDYA--LVTAVATLPKLVAGYYNDFQIYK 464

  Fly   435 VADTTMAALHAANNFFESSKPWTLKAGAPDGNQARLETIIAMTMDALRLSGIVLQPIIPQLANRL 499
            ..:...:.:...|.|.:...||.|...:|: :...|.|::.:.::.||:.|.:|||:.|.||::|
Mouse   465 ALEAVSSCVRQTNGFVQRHAPWKLNWESPE-DAPWLGTVLHVALECLRVFGTLLQPVTPNLADKL 528

  Fly   500 LDKLSVPTAQRGWNYLAESFATSPNSSNSPAGLGESRQLDGQTSALLFQRILEETSAKEVKEQK 563
            |.:|.|.|.:||   |.|.:.. |.....|... |.|:| |..:.|||.| |:::..:.||..:
Mouse   529 LSRLGVSTTERG---LGELYFL-PRFYGHPCPF-EGRKL-GPDTGLLFPR-LDQSRTRLVKAHR 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_001262564.1	MetRS_core	20..356	CDD:173907	196/347 (56%)
		PRK11893	21..553	CDD:237012	260/552 (47%)
		Anticodon_Ia_like	365..503	CDD:299868	44/146 (30%)
Mars2	NP_780648.1	MetRS_core	37..379	CDD:173907	196/348 (56%)
		PRK11893	39..574	CDD:237012	259/551 (47%)
		'HIGH' region	45..55		9/9 (100%)
		'KMSKS' region	340..344		3/3 (100%)
		Anticodon_Ia_Met	388..532	CDD:153411	44/146 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849140
Domainoid	1	1.000	422	1.000	Domainoid score	I628
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6009
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1471
Isobase	1	0.950	-	0	Normalized mean entropy	S1506
OMA	1	1.010	-	-		QHG54021
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005001
OrthoInspector	1	1.000	-	-		oto92226
orthoMCL	1	0.900	-	-		OOG6_101119
Panther	1	1.100	-	-	LDO	PTHR43326
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1450
SonicParanoid	1	1.000	-	-		X3534
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740