DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MetRS-m and Mars2

DIOPT Version :9

Sequence 1:	NP_001262564.1	Gene:	MetRS-m / 41733	FlyBaseID:	FBgn0027083	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_003750747.1	Gene:	Mars2 / 100911305	RGDID:	1311527	Length:	586	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	264/584 - (45%)
Similarity:	351/584 - (60%)	Gaps:	45/584 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CLRY-------LGTRYNSSHYVTTPIFYVNAAPHIGHLYSAVIADAHCRYQRLRYP-EQDVRLCT 64
            |.||       .|....:..|.|||||||||||||||||||::|||.||::|||.| ....|..|
  Rat    19 CRRYSSCSPSASGDAREARAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRVPGSGSTRFST 83

  Fly    65 GTDEHGTKIQQAASLHGVPVAKYCDDISQRYREVFRSASIQQDDFIRTTEDRHKRAVANFWRTLH 129
            ||||||.||||||:..|:...:.||.:|.::.::||.|.|...|||||||.||:.||.:||..|.
  Rat    84 GTDEHGLKIQQAAATAGLAPIELCDRVSAQFLQLFREAGISSTDFIRTTEARHRVAVQHFWGVLE 148

  Fly   130 TRGHIYSAAYSGWYCVSDETFLTDSQLRLDEATGTR----------YSLESGHPVEWTEETNYMF 184
            .||.:|...|.||||.|||.|       |.||..||          .||||||||.||:|.||:|
  Rat   149 ARGLLYKGIYEGWYCASDECF-------LPEAKVTRQVGPSGDPCPVSLESGHPVSWTKEENYIF 206

  Fly   185 RLSQFQDDVRHWVKTEAR-VRPAKFEKILLDTLSEPLPDVSVSRPSNRVHWAIPVPDDDSQTVYV 248
            :||||::.::.|::...: :.|..|.:::|..|.|.|||:||||.|:.:||.||||.|||||:||
  Rat   207 KLSQFREPLQRWLRNNPQAITPEPFHQVVLQWLEEELPDLSVSRRSSHLHWGIPVPGDDSQTIYV 271

  Fly   249 WLDALVNYLSSVGYPDEKFSAHWPPAQQVIGKDILKFHGIYWTAFLLAAGLEPPGQLYVHSHWTV 313
            |||||||||:.|||||..|.:.||....:|||||||||.|||.|.||.|||.||.::.|||||||
  Rat   272 WLDALVNYLTVVGYPDADFKSWWPATSHIIGKDILKFHAIYWPALLLGAGLRPPHRICVHSHWTV 336

  Fly   314 DGQKMSKSKHNVVDPLQAAQQYTMEGLRYFLLREGVAHSDGNYSHVKAQRILNSELADTLGNLLS 378
            .|||||||..|||||.....:||::|.||||||:||.:.|.:|...|..::|:|||||.||.||:
  Rat   337 SGQKMSKSLGNVVDPRTCLDRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLDSELADALGGLLN 401

  Fly   379 RASAKSLNPGQIYPS------PSAEHL---ADLLRSLDVAKRLQDSLLQLSERCESHYECNHFHL 434
            |.:|..:||...|||      ||...|   :..:::.|.|  |.:::..|.:....:|.....:.
  Rat   402 RCTAYRINPSGTYPSFCAACFPSEPGLMGPSVRVQAEDYA--LVNAVATLPKLVAGYYNDFQIYK 464

  Fly   435 VADTTMAALHAANNFFESSKPWTLKAGAPDGNQARLETIIAMTMDALRLSGIVLQPIIPQLANRL 499
            ..:...:.:...|.|.:...||.|...:| .:...|.|::.:.::.||:.|.:|||:.|.||::|
  Rat   465 ALEAVSSCVRQTNGFVQRHAPWKLTWESP-ADAPWLGTVLHVALECLRVFGTLLQPVTPNLADKL 528

  Fly   500 LDKLSVPTAQRGWNYLAESFATSPNSSNSPAGLGESRQLDGQTSALLFQRILEETSAKEVKEQK 563
            |.:|.|.|.:|.   |.|.:.. |.....|... |.|:| |..:.|||.| |:::..:.||..:
  Rat   529 LSRLGVSTTERS---LGELYFL-PRFYGHPCPF-EGRKL-GPDTGLLFPR-LDQSRTRLVKAHR 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MetRS-m	NP_001262564.1	MetRS_core	20..356	CDD:173907	195/347 (56%)
		PRK11893	21..553	CDD:237012	258/552 (47%)
		Anticodon_Ia_like	365..503	CDD:299868	44/146 (30%)
Mars2	XP_003750747.1	MetRS_core	37..379	CDD:173907	195/348 (56%)
		PRK11893	39..574	CDD:237012	257/551 (47%)
		Anticodon_Ia_Met	388..532	CDD:153411	44/146 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352756
Domainoid	1	1.000	423	1.000	Domainoid score	I607
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6009
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1444
OMA	1	1.010	-	-		QHG54021
OrthoDB	1	1.010	-	-		D334822at33208
OrthoFinder	1	1.000	-	-		FOG0005001
OrthoInspector	1	1.000	-	-		oto95791
orthoMCL	1	0.900	-	-		OOG6_101119
Panther	1	1.100	-	-	LDO	PTHR43326
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3534
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810