DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31326 and Sp212

DIOPT Version :9

Sequence 1:	NP_650344.2	Gene:	CG31326 / 41728	FlyBaseID:	FBgn0051326	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_996209.2	Gene:	Sp212 / 2768666	FlyBaseID:	FBgn0053329	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	177/568 - (31%)
Similarity:	261/568 - (45%)	Gaps:	115/568 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLLLASLINLVLGQL-PRNGCSGRFQY-----QGYQGQYIGLVEVRHPE--ANNQTLILQFSQQG 65
            ::::.|||.|...|| |.|.|...|:|     ||.||      |:..|.  .....:.::|||:|
  Fly     5 LIVIVSLIALAGAQLVPENSCPDYFRYVNDAFQGVQG------EITLPSLMRGRNRIDIRFSQRG 63

  Fly    66 YHDFEDYVGSISLVDDDEVTQENLRQGLPIRYRVDFPIPTIP------PKITSMQLNGVQLCSGG 124
            ..| ...|||:....|:...::       :.....|.|...|      ||:|.:..|...|||..
  Fly    64 EQD-ASAVGSLIPYPDENAVRQ-------LTGSAKFRIAVRPNSSNGLPKLTRLSYNEQILCSAS 120

  Fly   125 VYPKPRT--------GITLRITWTPSYISVFG--------VNPQ----PVPTRPRPAWQ------ 163
            .|..|.:        .|:..:...||  |||.        ||.|    |..:|....|:
  Fly   121 EYRPPNSFFNRFYELDISGSLASFPS--SVFNPFTRDGLDVNVQTVFYPTSSRGNDIWRGFTQPW 183

  Fly   164 ----DESPQIDYRETRPSQPRLEDSGELFGRSNESLPAFQNPGWGTAPQQANPNRGITSQPEIP- 223
                :.||.:......|:        |:|              |    .|..|:..||..|.:|
  Fly   184 TTVSNRSPAVVTPAPTPT--------EIF--------------W----NQPVPSVPITFAPPVPT 222

  Fly   224 ---SPVPQRPTPNPSRSNAPQQAVRSPVDLVPQQ--NPSS--NGIPCGRERASTTPLIFQGKSLQ 281
               ||.|..|.|.|..:  |...|..|....|.|  :|.|  :.:.|||| .||||.|.:|....
  Fly   223 ITSSPAPAPPPPPPLPT--PPAVVTVPPATPPPQRFDPRSQISSVVCGRE-GSTTPFIVRGNEFP 284

  Fly   282 RGQLPWLVAIFERRESNGPAFICGGTLISTSTVLSAAHCFRAPGRDLPASRLAVSLGRNTLAIH- 345
            |||.|||.|:: .:|....||.|.|:|||:|.|:|||||......|    |:.|.|||..|..:
  Fly   285 RGQYPWLSAVY-HKEVRALAFKCRGSLISSSIVISAAHCVHRMTED----RVVVGLGRYDLDDYG 344

  Fly   346 SDG-EFRGVSQLIIHENFQFKQFTEADLALVRLDEPVRYTDYIVPICLWST-SNRMDLPQGLKSY 408
            .|| |.|.|.:|:.|.::..:.:::||:||:.::.||.:.|.|.|||:|:. ::|.....|   :
  Fly   345 EDGAEMRNVMRLLWHPDYNTRSYSDADIALITIERPVTFNDIIAPICMWTVEASRTVSTTG---F 406

  Fly   409 VAGWGPDETGTGNTEVSKVTDLNIVSEANCALELPHVLVQPSSLCA-KKTGAGPCASDGGGPLML 472
            :||||.|| .:..|:..:|.:..|.|...||......:|...|||| .:.|:|||..|.||.||:
  Fly   407 IAGWGRDE-DSSRTQYPRVVEAEIASPTVCASTWRGTMVTERSLCAGNRDGSGPCVGDSGGGLMV 470

  Fly   473 REQDVWVLRGVISGGVINEK--ENTCELSKPSVFTDVAKHIEWVRQKM 518
            ::.|.|:|||::|.|   |:  ..||:|::..::.|::|||.|:.:.:
  Fly   471 KQGDRWLLRGIVSAG---ERGPAGTCQLNQYVLYCDLSKHINWISENI 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31326	NP_650344.2	GD_N	26..126	CDD:292649	29/112 (26%)
		Tryp_SPc	277..517	CDD:238113	93/245 (38%)
		Tryp_SPc	277..514	CDD:214473	92/242 (38%)
Sp212	NP_996209.2	GD_N	23..122	CDD:292649	29/112 (26%)
		Tryp_SPc	277..514	CDD:238113	94/248 (38%)
		Tryp_SPc	277..511	CDD:214473	93/245 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45436919
Domainoid	1	1.000	145	1.000	Domainoid score	I9368
eggNOG	1	0.900	-	-		E33208_3BPFK
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I6368
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D294086at33208
OrthoFinder	1	1.000	-	-		FOG0001808
OrthoInspector	1	1.000	-	-		mtm9620
orthoMCL	1	0.900	-	-		OOG6_124240
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X174
	10	9.700