DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9649 and Sp212

DIOPT Version :9

Sequence 1:	NP_650343.1	Gene:	CG9649 / 41727	FlyBaseID:	FBgn0038211	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_996209.2	Gene:	Sp212 / 2768666	FlyBaseID:	FBgn0053329	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	175/541 - (32%)
Similarity:	257/541 - (47%)	Gaps:	81/541 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LGFLIAILQISYISAQNLPYIQCPMIFRYLEYDNQFIG-HLQLTLDS-TNTENVVRVELSQRGRN 69
            |..::.:..|:...||.:|...||..|||:  ::.|.| ..::||.| ....|.:.:..||||..
  Fly     3 LELIVIVSLIALAGAQLVPENSCPDYFRYV--NDAFQGVQGEITLPSLMRGRNRIDIRFSQRGEQ 65

  Fly    70 TPSTPGTLNFLEDEDSLRHRLTNNEPINYRIDFPTPGVVPKLTKVTVNGKVACEAVPFGAPST-- 132
            ..|..|:|....||:::| :||.:......:...:...:||||:::.|.::.|.|..:..|::
  Fly    66 DASAVGSLIPYPDENAVR-QLTGSAKFRIAVRPNSSNGLPKLTRLSYNEQILCSASEYRPPNSFF 129

  Fly   133 ----RLSLSRTLRT----------------SVPLAAIPPSQRTDHQWPQAPQTNYTVYEEEEEEE 177
                .|.:|.:|.:                :|.....|.|.|.:..|....|...|
  Fly   130 NRFYELDISGSLASFPSSVFNPFTRDGLDVNVQTVFYPTSSRGNDIWRGFTQPWTT--------- 185

  Fly   178 PVQRRRPQQRPSRPRP------QQAPSRP----------RLQPVPQLPQEPEFQT-SARPSVHPS 225
             |..|.|......|.|      |..||.|          ...|.|..|..|...| .|..:|.|:
  Fly   186 -VSNRSPAVVTPAPTPTEIFWNQPVPSVPITFAPPVPTITSSPAPAPPPPPPLPTPPAVVTVPPA 249

  Fly   226 NTPAQASKFYPQTIGQLSG-ICGREKVIQTPFIHNGIEVERGQLPWMAALFEHVGRDYNFLCGGT 289
            ..|.|  :|.|::  |:|. :||||. ..||||..|.|..|||.||::|::....|...|.|.|:
  Fly   250 TPPPQ--RFDPRS--QISSVVCGREG-STTPFIVRGNEFPRGQYPWLSAVYHKEVRALAFKCRGS 309

  Fly   290 LISARTVISAAHCFRFGSRNLPGERTIVSLGRNSLDLF-SSGATL-GVARLLIHEQYNPNVYTDA 352
            |||:..|||||||.    ..:..:|.:|.|||..||.: ..||.: .|.|||.|..||...|:||
  Fly   310 LISSSIVISAAHCV----HRMTEDRVVVGLGRYDLDDYGEDGAEMRNVMRLLWHPDYNTRSYSDA 370

  Fly   353 DLALLQLSNHVDIGDYIKPICLWNENFLLELPSGHKSYVAGWGEDEKGNRNTRLAKMTDTDIITQ 417
            |:||:.:...|...|.|.|||:|.......:.:  ..::||||.||..:| |:..::.:.:|.:.
  Fly   371 DIALITIERPVTFNDIIAPICMWTVEASRTVST--TGFIAGWGRDEDSSR-TQYPRVVEAEIASP 432

  Fly   418 WEC----RGNLSEENAKFITSHTICASNAQASGPCSGDSGGGLMLQEQDIWMLRGVVSAGQR-MT 477
            ..|    ||.:       :|..::||.|...||||.||||||||:::.|.|:|||:||||:| ..
  Fly   433 TVCASTWRGTM-------VTERSLCAGNRDGSGPCVGDSGGGLMVKQGDRWLLRGIVSAGERGPA 490

  Fly   478 NRCNLTLPVIYTDVAKHIEWL 498
            ..|.|...|:|.|::|||.|:
  Fly   491 GTCQLNQYVLYCDLSKHINWI 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9649	NP_650343.1	GD_N	29..124	CDD:292649	29/96 (30%)
		Tryp_SPc	257..498	CDD:238113	98/247 (40%)
		Tryp_SPc	259..497	CDD:214473	97/244 (40%)
Sp212	NP_996209.2	GD_N	23..122	CDD:292649	30/101 (30%)
		Tryp_SPc	277..514	CDD:238113	99/249 (40%)
		Tryp_SPc	277..511	CDD:214473	98/247 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45436925
Domainoid	1	1.000	145	1.000	Domainoid score	I9368
eggNOG	1	0.900	-	-		E33208_3BPFK
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I6368
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D294086at33208
OrthoFinder	1	1.000	-	-		FOG0001808
OrthoInspector	1	1.000	-	-		mtm9620
orthoMCL	1	0.900	-	-		OOG6_124240
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X174
	10	9.700