Protein Alignment Dop1R1 and TAAR5

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_003958.2
• Gene: TAAR5 / 9038
• HGNCID: 30236
• Length: 337
• Species: Homo sapiens
• Alignment Length: 342
• Identity: 94/342 - (27%)
• Similarity: 151/342 - (44%)
• Gaps: 49/342 - (14%)

  Fly   117 GEEPEPLSLVSIVVVGIFLSVL--IFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVAS 179
            |..|..:..:.|.:| |:|:..  :.:.|.||:.|..|:...::|....|..|.|||:||:|:..
Human    22 GSCPRTVHTLGIQLV-IYLACAAGMLIIVLGNVFVAFAVSYFKALHTPTNFLLLSLALADMFLGL 85

  Fly   180 LVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRV 244
            ||:..:.:..:...|.||...|......|.:....||.:||.||:||:..|.|||.|....|.||
Human    86 LVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRV 150

  Fly   245 AVITIAAIW-LLAAFVSF------VPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCI 302
            |:..|.|.| :.||:.|.      |...|.....:.|.:        .:|.|.|...:..::..:
Human   151 ALRYILAGWGVPAAYTSLFLYTDVVETRLSQWLEEMPCV--------GSCQLLLNKFWGWLNFPL 207

  Fly   303 SFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSS 367
             |:.||::||.:|.:::..|.:..:.|..:::....|.|.
Human   208 -FFVPCLIMISLYVKIFVVATRQAQQITTLSKSLAGAAKH------------------------- 246

  Fly   368 PYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYS 432
                 :.|||.|:|:.:|::|:||:||....:..:..........|.|..|..|.|||.|||||.
Human   247 -----ERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSACNPIIYV 306

  Fly   433 IFNKEFRDAFKRILTMR 449
            ...:.||.|.|..|:.:
Human   307 FSYQWFRKALKLTLSQK 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	88/320 (28%)
		TM helix 1	130..156	CDD:320193	8/27 (30%)
		TM helix 2	163..189	CDD:320193	10/25 (40%)
		TM helix 3	201..231	CDD:320193	10/29 (34%)
		TM helix 4	243..265	CDD:320193	10/28 (36%)
		TM helix 5	292..321	CDD:320193	6/28 (21%)
		TM helix 6	371..401	CDD:320193	11/29 (38%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
TAAR5	NP_003958.2	7tmA_TAAR5	35..316	CDD:320441	88/320 (28%)
		TM helix 1	36..62	CDD:320441	8/26 (31%)
		TM helix 2	69..95	CDD:320441	10/25 (40%)
		TM helix 3	107..137	CDD:320441	10/29 (34%)
		TM helix 4	149..172	CDD:320441	9/22 (41%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	176..189		2/12 (17%)
		TM helix 5	196..225	CDD:320441	7/29 (24%)
		TM helix 6	245..275	CDD:320441	12/59 (20%)
		TM helix 7	284..309	CDD:320441	12/24 (50%)