Protein Alignment Dop1R1 and TAAR8

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_444508.1
• Gene: TAAR8 / 83551
• HGNCID: 14964
• Length: 342
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 106/367 - (28%)
• Similarity: 164/367 - (44%)
• Gaps: 48/367 - (13%)

  Fly    88 LTNGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLA 152
            :|:.:....:...|.:   .|.|.::|       |.|..|.|::....|....|:|.||:||..:
Human     1 MTSNFSQPVVQLCYED---VNGSCIET-------PYSPGSRVILYTAFSFGSLLAVFGNLLVMTS 55

  Fly   153 IYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASIL 217
            :...:.|....|..:||||.||..|...||.|:.|..:...|.|||:||......||....:|:|
Human    56 VLHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVL 120

  Fly   218 NLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGK 282
            :||.|.:||||.:.|||.|....|..|:.|.|:..|:|....|......|::         |:|.
Human   121 HLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVN---------DDGL 176

  Fly   283 KYPTCALDLTPTYAVVSS-------CISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAE 340
            :....||:......::.|       .:.|:.|.:|||.:|.:::..|::  ::||..|...:|..
Human   177 EELVSALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQ--QAIKIETTSSKVES 239

  Fly   341 KQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCK 405
            ......||..|.                    :.|||.|:||.:..|:|.|:|:....:..||..
Human   240 SSESYKIRVAKR--------------------ERKAAKTLGVTVLAFVISWLPYTVDILIDAFMG 284

  Fly   406 TCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILT 447
            .......::|..|..|.|||.||:||::|...||.|.|.||:
Human   285 FLTPAYIYEICCWSAYYNSAMNPLIYALFYPWFRKAIKLILS 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	93/318 (29%)
		TM helix 1	130..156	CDD:320193	7/25 (28%)
		TM helix 2	163..189	CDD:320193	12/25 (48%)
		TM helix 3	201..231	CDD:320193	12/29 (41%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	7/35 (20%)
		TM helix 6	371..401	CDD:320193	10/29 (34%)
		TM helix 7	410..435	CDD:320193	10/24 (42%)
TAAR8	NP_444508.1	7tmA_TAAR6_8_9	32..321	CDD:320439	94/319 (29%)
		TM helix 1	33..59	CDD:320439	7/25 (28%)
		TM helix 2	66..92	CDD:320439	12/25 (48%)
		TM helix 3	104..134	CDD:320439	12/29 (41%)
		TM helix 4	146..169	CDD:320439	6/22 (27%)
		TM helix 5	193..222	CDD:320439	7/28 (25%)
		TM helix 6	250..280	CDD:320439	11/49 (22%)
		TM helix 7	289..314	CDD:320439	10/24 (42%)