Protein Alignment Dop1R1 and drd1a

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_021336831.1
• Gene: drd1a / 792634
• ZFINID: ZDB-GENE-130522-1
• Length: 363
• Species: Danio rerio
• Alignment Length: 333
• Identity: 145/333 - (43%)
• Similarity: 195/333 - (58%)
• Gaps: 29/333 - (8%)

  Fly   129 VVVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIADLFVASLVMTFAGVNDLLG 192
            |:.|.|||:||..::.||.|||.|:...|.|| ::.|.|:.|||::||.||.|||.:..|.::.|
Zfish    25 VLTGCFLSLLILSTLLGNTLVCAAVTKFRHLRSKVTNFFVISLAVSDLLVAILVMPWKAVTEVAG 89

  Fly   193 YWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAA 257
            :|.||| |||.|||||:|||||||||||.||:|||..|..|.||.|.:|.|||.:.|:..|.|:.
Zfish    90 FWPFGA-FCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPRVAFVMISVAWTLSV 153

  Fly   258 FVSFVPISLGIHRPDQPLIFEDNGKKY-----PTCALDLTPTYAVVSSCISFYFPCVVMIGIYCR 317
            .:||:|:.|..|:. ||..|.:....:     ..|...|..|||:.||.||||.|..:||..|.:
Zfish   154 LISFIPVQLKWHKA-QPTSFPEANASHRALLTDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTQ 217

  Fly   318 LYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVS---DHKAAVT 379
            :|..|||.::.|.|:.|..|.| |.|:.|:....|...:          |.:.:|   :.|...|
Zfish   218 IYRIAQKQIRRISALERAAESA-KIRHDSMGSSSNVDSE----------SSFKLSFKRETKVLKT 271

  Fly   380 VGVIMGVFLICWVPFFCVNITAAFCK------TCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEF 438
            :.||||||:.||:|||.:|....|||      .||...||.:..|.|::||:.|||||: ||.:|
Zfish   272 LSVIMGVFVCCWLPFFILNCMVPFCKRTSVGLPCISPTTFDVFVWFGWANSSLNPIIYA-FNADF 335

  Fly   439 RDAFKRIL 446
            |.||..:|
Zfish   336 RRAFAILL 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	141/326 (43%)
		TM helix 1	130..156	CDD:320193	12/25 (48%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	23/29 (79%)
		TM helix 4	243..265	CDD:320193	9/21 (43%)
		TM helix 5	292..321	CDD:320193	14/28 (50%)
		TM helix 6	371..401	CDD:320193	15/32 (47%)
		TM helix 7	410..435	CDD:320193	11/24 (46%)
drd1a	XP_021336831.1	7tm_GPCRs	24..339	CDD:475119	142/327 (43%)
		TM helix 1	27..51	CDD:410628	12/23 (52%)
		TM helix 2	61..83	CDD:410628	12/21 (57%)
		TM helix 3	98..120	CDD:410628	18/21 (86%)
		TM helix 4	143..159	CDD:410628	5/15 (33%)
		TM helix 5	193..216	CDD:410628	12/22 (55%)
		TM helix 6	269..291	CDD:410628	12/21 (57%)
		TM helix 7	308..333	CDD:410628	12/25 (48%)