Protein Alignment Dop1R1 and htr2b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001038208.1
• Gene: htr2b / 751784
• ZFINID: ZDB-GENE-081022-57
• Length: 443
• Species: Danio rerio
• Alignment Length: 361
• Identity: 112/361 - (31%)
• Similarity: 181/361 - (50%)
• Gaps: 52/361 - (14%)

  Fly   133 IFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLL-GYWIF 196
            :.:.::|..::.|||||.||:..||.|:...|.||.|||:|||.|..|||..|.|..|. ..|..
Zfish    19 LLILLVIVPTIGGNILVILAVSLERKLQNATNFFLMSLAVADLLVGLLVMPIALVTVLYNSTWPL 83

  Fly   197 GAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSF 261
            ....|..|:..||:.|||||::|||||:||||.||.|:::.::.:|...:..||.:||::..::
Zfish    84 ADFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKIALVWLISIGIA- 147

  Fly   262 VPISL-GIHRPDQP-LIFEDNGKKYPTCALDLTP----TYAVVSSCISFYFPCVVMIGIYCRLYC 320
            :||.: |:...|.| :.|..|    .||.  |:|    .:.|..|.::|:.|..:|:.||.....
Zfish   148 IPIPIKGLQFFDHPNITFNKN----HTCL--LSPEGFRDFKVYGSLVAFFIPLAIMMIIYLLTIQ 206

  Fly   321 YAQKHVKSIKA-VTRPGEVAEKQRYKSIRRPKNQPKKFKVRN----------------------- 361
            ..:|....::: ..||......|:..|:..   .|:|..:.|
Zfish   207 VLRKKAYLLRSRAARPSISTVFQQELSVLA---SPEKMVISNGIKRDRTLNPVNPITGDEVPLRR 268

  Fly   362 ---LHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGG---QTFKILTWLG 420
               :...|.....::.:|:..:|::..:|::.|.|||..|:|:..|:.|.|.   |...|..|:|
Zfish   269 MSTIGKRSMQNLTNEQRASKVLGIVFMLFVVMWCPFFITNVTSVLCERCNGNLVDQLLDIFQWVG 333

  Fly   421 YSNSAFNPIIYSIFNKEFRDAFKRILT-----MRNP 451
            |.:|..||::|::||:.||.||:|.:|     :|.|
Zfish   334 YVSSGINPLVYTLFNRTFRLAFRRYITCNYKSVRTP 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	106/345 (31%)
		TM helix 1	130..156	CDD:320193	8/22 (36%)
		TM helix 2	163..189	CDD:320193	15/25 (60%)
		TM helix 3	201..231	CDD:320193	18/29 (62%)
		TM helix 4	243..265	CDD:320193	5/21 (24%)
		TM helix 5	292..321	CDD:320193	8/32 (25%)
		TM helix 6	371..401	CDD:320193	8/29 (28%)
		TM helix 7	410..435	CDD:320193	9/27 (33%)
htr2b	NP_001038208.1	7tm_GPCRs	15..362	CDD:475119	110/352 (31%)
		TM helix 1	17..41	CDD:410628	8/21 (38%)
		TM helix 2	50..72	CDD:410628	13/21 (62%)
		TM helix 3	89..111	CDD:410628	12/21 (57%)
		TM helix 4	134..150	CDD:410628	4/16 (25%)
		TM helix 5	179..202	CDD:410628	6/22 (27%)
		TM helix 6	287..309	CDD:410628	6/21 (29%)
		TM helix 7	323..348	CDD:410628	9/24 (38%)