Protein Alignment Dop1R1 and hrh2a

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001038803.2
• Gene: hrh2a / 735303
• ZFINID: ZDB-GENE-070531-4
• Length: 369
• Species: Danio rerio
• Alignment Length: 440
• Identity: 143/440 - (32%)
• Similarity: 208/440 - (47%)
• Gaps: 94/440 - (21%)

  Fly   125 LVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVND 189
            :.|.:.:.:.|||||.|:|:||||||||:|..|.||.:.|.|:.|||:.|..:.:||:.|:.:..
Zfish     1 MTSQIALAVTLSVLILLTVSGNILVCLAVYATRRLRNVTNCFIVSLAVTDFLLGALVLPFSTLYQ 65

  Fly   190 LLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTR-RVAVITIAAIW 253
            :.|.|..||.||:.:::.|||..|||||||.|||:|||..:..||||...|.. ||..| :|.||
Zfish    66 VTGDWPLGAHFCNIYISLDVMLCTASILNLFAISLDRYFAVTAPLRYPMLVLPWRVGAI-LATIW 129

  Fly   254 LLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRL 318
            |::..||||||.||.:..|..:.....|.....|..:|.||||:|.:..:||.|.:.|...|.|:
Zfish   130 LVSVGVSFVPIHLGWNTRDLSVQNIREGDHARDCRFELNPTYAIVDAFSTFYLPLLAMCWSYHRV 194

  Fly   319 YCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVI 383
            :..|:...|               |..|.||.....:...:..|.         :|||.||:.|:
Zfish   195 FRIARMRAK---------------RIISTRRGSTSSQGVTILTLR---------EHKATVTLAVV 235

  Fly   384 MGVFLICWVPFFCVNITAAFCKTCIG-------GQTFK-ILTWLGYSNSAFNPIIYSIFNKEFRD 440
            :|.|::||.|:|..       .|.:|       .||.: ::.||||:|||.||::|:..|::||.
Zfish   236 LGAFVVCWFPYFTF-------FTIMGIRNEENPPQTAQSVVLWLGYANSALNPVLYATLNRDFRS 293

  Fly   441 AFKRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVVMNSGRSSAELEQVSAIXPKCCLNLT 505
            |:.::|       |                             |....:.|....|.......:|
Zfish   294 AYAKLL-------C-----------------------------GGRRCKTETTIPIAATAAGTMT 322

  Fly   506 G-----GGATWLPCGCGGLRVDDD---DDGALTTRYVPXDSVTAATATIV 547
            |     .||.:||..|..|:..::   ||.:.|         ..||.|:|
Zfish   323 GHAHSSKGAGFLPRTCVLLKDSENRMLDDNSAT---------NGATVTVV 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	121/320 (38%)
		TM helix 1	130..156	CDD:320193	16/25 (64%)
		TM helix 2	163..189	CDD:320193	9/25 (36%)
		TM helix 3	201..231	CDD:320193	17/29 (59%)
		TM helix 4	243..265	CDD:320193	12/21 (57%)
		TM helix 5	292..321	CDD:320193	11/28 (39%)
		TM helix 6	371..401	CDD:320193	12/29 (41%)
		TM helix 7	410..435	CDD:320193	12/25 (48%)
hrh2a	NP_001038803.2	7tmA_Histamine_H2R	5..295	CDD:320179	121/321 (38%)
		TM helix 1	6..32	CDD:320179	16/25 (64%)
		TM helix 2	39..66	CDD:320179	9/26 (35%)
		TM helix 3	77..107	CDD:320179	17/29 (59%)
		TM helix 4	119..139	CDD:320179	10/20 (50%)
		TM helix 5	168..198	CDD:320179	11/29 (38%)
		TM helix 6	223..253	CDD:320179	14/45 (31%)
		TM helix 7	263..288	CDD:320179	12/24 (50%)