Protein Alignment Dop1R1 and 5-HT2B

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_061501050.1
• Gene: 5-HT2B / 5667641
• VectorBaseID: AGAMI1_004218
• Length: 908
• Species: Anopheles gambiae
• Alignment Length: 904
• Identity: 152/904 - (16%)
• Similarity: 233/904 - (25%)
• Gaps: 528/904 - (58%)

  Fly    30 ISSSTTIINTSSATTIGGNHTSGS-------TGFSTNSTLLDADHLPLQLTTA--------KVDL 79
            :|.:.|:....:...:|....:|.       ||:.:.....:....|:...|.        ::|.
Mosquito    37 LSGTATVTLAGATVGVGVRGLAGGLVRPPAYTGYVSYMKQFNFTGNPIDNRTGAEAGLGPDRIDA 101

  Fly    80 DIEIDIQLLTNGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVA 144
            |.:.|        ||::| :.:|  .|                 :|::|        :|:|.:.|
Mosquito   102 DDDED--------DGSSL-ALHN--YW-----------------ALLAI--------ILVFGTAA 130

  Fly   145 GNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDV 209
            |||||||||..||.|:.:.|.||.||||.||.||..||....:..:.|::...:::|..|:..||
Mosquito   131 GNILVCLAIVWERRLQNVTNYFLMSLAITDLMVALSVMPLGILTLVKGHFPLDSEYCLVWICLDV 195

  Fly   210 MCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQP 274
            :..||||::||.||:|||:.::.|:::||..|||..|:.|:.:|||:..:| :|:|| ::..:..
Mosquito   196 LFCTASIMHLCTISVDRYLSLRYPMKFGRNKTRRRVVLKISFVWLLSIAMS-LPLSL-MYSKNHA 258

  Fly   275 LIFEDNGKKYPTCALDLTPTYAVVSSCISFYFP-CVVMIGIYCRLYCYAQK-------------- 324
            .:..|.     ||.:. .|.|.:|.|.:.||.| ||::|.....:...||:
Mosquito   259 SVLVDG-----TCQIP-DPVYKLVGSIVCFYIPLCVMLITYTLTVRLLAQQSENLGGVGSGGGWS 317

  Fly   325 ------------------------------HVKS------------------------------I 329
                                          |..|                              :
Mosquito   318 SGWLGQAPAFDRRNTWKRIIKLSLPAAQNPHAHSAASTDTELSTLDNHDLWLLESSIPEPSSITM 382

  Fly   330 KAVTRPGE--------------------------------------------------------- 337
            .|:.|.||
Mosquito   383 TAMQRFGEEMLKLSQGLESVAQHSDRNSGQNGSSRSPEPSREKESFRKKPANAKHAPTPVTMVTV 447

  Fly   338 ---VAEKQRYKS-----IRRPKNQP-------KKFK----------------------------- 358
               |..|:|..|     .||....|       |:||
Mosquito   448 RSPVPSKKRRSSTSTWIARRNSGTPPPVRLVRKRFKSLPHALPPPASDDIEVDEQFMQDVLYELR 512

  Fly   359 ----------------------------------------------VRNLH-------------- 363
                                                          .|..|
Mosquito   513 DREDRGSVHGSSARPGAAGLDGVPAAASRATSDRREGRDAGSNPAGPRQAHPLAAPSQTAATLKL 577

  Fly   364 ----------------------------------------------------------------- 363
                                                                             
Mosquito   578 PPPCKCPFFGEGAPGRQQYLRPAEIKIVKTSTDFGPMGGAASNGDSLVYSTISISSGSNVTTQPT 642

  Fly   364 --------------------------------------------------------THSSPYHVS 372
                                                                    |.:||..||
Mosquito   643 RSISSSLSTLPASALASPSRKGSAPKGISVVTWDQRRHQRRGSSFGGARTSLLLTPTKASPSSVS 707

  Fly   373 ----------------------------------------------------------------- 372
                                                                             
Mosquito   708 LRRSINLRHSALEGGGGGGGGSAGETMFRGAPKKNSSSPCLMQHQTGGGGGGGAVGGGNGTAVAM 772

  Fly   373 --------------------------------------------DHKAAVTVGVIMGVFLICWVP 393
                                                        :.||...:||:...|:|.|.|
Mosquito   773 MAVAAASSTVPTLATTTMAVRSHHSRNSSMISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWAP 837

  Fly   394 FFCVNITAAFCKTC---IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMR 449
            ||.:|:..:.||.|   |....|:.:|||||::|..|||.|:||||.|||||:::|..|
Mosquito   838 FFVLNLLPSVCKHCEDNIDQWVFEFVTWLGYASSLVNPIFYTIFNKAFRDAFRKVLLCR 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	130/780 (17%)
		TM helix 1	130..156	CDD:320193	12/25 (48%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	15/29 (52%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	10/29 (34%)
		TM helix 6	371..401	CDD:320193	13/138 (9%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
5-HT2B	XP_061501050.1	None