DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and LOC563567

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_005158584.1	Gene:	LOC563567 / 563567	-ID:	-	Length:	447	Species:	Danio rerio

Alignment Length:	324	Identity:	135/324 - (41%)
Similarity:	189/324 - (58%)	Gaps:	26/324 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 VVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIADLFVASLVMTFAGVNDLLGY 193
            ::|..|.:||..::.||.|||.|:...|.|| ::.|.|:.|||::|||||.|||.:..::.:.|.
Zfish    36 LLGFVLFLLIVSTLLGNTLVCAAVVKFRHLRSKVTNFFVISLAVSDLFVAVLVMPWEAISAVAGT 100

  Fly   194 WIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAF 258
            |:|| :||..|:|||:|||||||||||.||:|||..|..|.||.|.:|.|||.:.|...|.|:..
Zfish   101 WLFG-RFCGIWIAFDIMCSTASILNLCIISVDRYWAIASPFRYERKMTHRVAFMMIGVAWTLSIL 164

  Fly   259 VSFVPISLGIHRPDQPLIFED----NGKKY-PTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRL 318
            :||:|:.|..|..|..   |:    ||..| ..|..:|..|||:.||.||||.|.::||..|.|:
Zfish   165 ISFIPVQLNWHMADDD---EEGAGGNGTDYSDNCKANLNRTYAISSSLISFYIPVIIMIATYTRI 226

  Fly   319 YCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPK-KFKVRNLHTHSSPYHVSDHKAAVTVGV 382
            :..||..::.|.::.|..|.|:.....:....:|..| .||             .:.|...|:.:
Zfish   227 FRIAQTQIRRISSLERAVEHAQNHHQSNDCSNENSLKTTFK-------------KETKVLKTLSI 278

  Fly   383 IMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL 446
            |||||:.||:|||.:|....||: |:...||.|..|.|::||:.||:||: ||.:||.||..||
Zfish   279 IMGVFVFCWLPFFVLNCMVPFCQ-CVSDTTFTIFVWFGWANSSLNPVIYA-FNADFRKAFSSIL 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	66/132 (50%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	121/292 (41%)
LOC563567	XP_005158584.1	7tmA_D1-like_dopamine_R	35..336	CDD:320185	131/318 (41%)
		TM helix 1	36..62	CDD:320185	10/25 (40%)
		TM helix 2	70..97	CDD:320185	13/26 (50%)
		TM helix 3	107..137	CDD:320185	21/29 (72%)
		TM helix 4	149..169	CDD:320185	8/19 (42%)
		TM helix 5	200..230	CDD:320185	14/29 (48%)
		TM helix 6	267..297	CDD:320185	14/42 (33%)
		TM helix 7	305..330	CDD:320185	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2313
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136216
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3173
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1045889at2759
OrthoFinder	1	1.000	-	-		FOG0001416
OrthoInspector	1	1.000	-	-		otm24276
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.970