Protein Alignment Dop1R1 and htr1b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001122181.1
• Gene: htr1b / 561647
• ZFINID: ZDB-GENE-081022-141
• Length: 380
• Species: Danio rerio
• Alignment Length: 415
• Identity: 116/415 - (27%)
• Similarity: 182/415 - (43%)
• Gaps: 90/415 - (21%)

  Fly    90 NGYDGTTLTSF--YNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLA 152
            :||...|...|  .|.|:.||.: :.....|:.|  |....|.:...|.::...::..|..|...
Zfish     4 SGYFKPTPAHFEVLNSSTGTNVT-LTPKTDEKQE--SFAFQVTLSSVLGLITLATILSNAFVIAT 65

  Fly   153 IYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASIL 217
            |...|.|:...|..:||||:.||.|:.|||....:..:...|..|...||.|::.|:.|.|||||
Zfish    66 ISQSRKLQTPANFLIASLAVTDLLVSVLVMPICVLYTVTREWTLGQVICDIWLSSDITCCTASIL 130

  Fly   218 NLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVP-----ISLGIHRPDQPLIF 277
            :||.|::|||..|.|.:.|.:..|:..|...:|..|::|..:|..|     :..|
Zfish   131 HLCVIALDRYWAITDAVEYAKKRTQARAAGMVATAWIIAISISLPPFFWRQVKAG---------- 185

  Fly   278 EDNGKKYPTCALDLTPT-YAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEK 341
                 :..||:::.... |.:.|:..:||.|.:::|.:|.|:|..|:|.:..
Zfish   186 -----ELTTCSVNTDHIFYTIYSTFGAFYIPTLLLIALYGRIYVEARKRILK------------- 232

  Fly   342 QRYKSIRRPKNQPKKFKVRNLHTHS-------SPYH----------------------VSD---- 373
                  :.||...|:....:|.|:|       ||.|                      |||
Zfish   233 ------QSPKKPGKRLTSAHLSTNSPASVASTSPLHCGRQDLCSDSGSLGSDNQIRVTVSDSLLE 291

  Fly   374 ---------HKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPI 429
                     .||..|:|:|:|.:::||:|||...:....|.:|...:.|...|||||.||..|||
Zfish   292 KKRISAARERKATKTLGIILGAYIVCWLPFFIYTLLIPLCSSCFSPELFDFFTWLGYVNSLINPI 356

  Fly   430 IYSIFNKEFRDAFKRILTMRNPWCC 454
            ||::.|.:|:.||.::::.|   ||
Zfish   357 IYTMSNDDFKKAFHKVISFR---CC 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	99/359 (28%)
		TM helix 1	130..156	CDD:320193	4/25 (16%)
		TM helix 2	163..189	CDD:320193	11/25 (44%)
		TM helix 3	201..231	CDD:320193	16/29 (55%)
		TM helix 4	243..265	CDD:320193	6/26 (23%)
		TM helix 5	292..321	CDD:320193	9/29 (31%)
		TM helix 6	371..401	CDD:320193	14/42 (33%)
		TM helix 7	410..435	CDD:320193	13/24 (54%)
htr1b	NP_001122181.1	7tm_GPCRs	39..369	CDD:475119	100/363 (28%)
		TM helix 1	44..68	CDD:320455	4/23 (17%)
		TM helix 2	77..99	CDD:320455	11/21 (52%)
		TM helix 3	115..137	CDD:320455	12/21 (57%)
		TM helix 4	160..176	CDD:320455	4/15 (27%)
		TM helix 5	197..220	CDD:320455	6/22 (27%)
		TM helix 6	304..326	CDD:320455	9/21 (43%)
		TM helix 7	337..362	CDD:320455	13/24 (54%)