Protein Alignment Dop1R1 and htr2ab

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_009300470.1
• Gene: htr2ab / 559806
• ZFINID: ZDB-GENE-120215-60
• Length: 458
• Species: Danio rerio
• Alignment Length: 418
• Identity: 129/418 - (30%)
• Similarity: 201/418 - (48%)
• Gaps: 60/418 - (14%)

  Fly    59 NSTLLDADHLPLQLTTAKVDLDIEIDIQL----LTNGYDGTTLTSFYNESSWTNASEMDTIVGEE 119
            |.|..:...|.:....:| |..:|..:.|    |.|..|       .|.|...|.||..:
Zfish     4 NGTAAELRSLGISAEISK-DTSMEQKVSLGNAVLNNSMD-------CNGSEERNRSEFSS----- 55

  Fly   120 PEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTF 184
               ...|....|.:.:|::|.::|.|||||.:|:..||.|:...|.||.||||.|:.:..|||..
Zfish    56 ---SDYVQKNWVALLISLVIIITVTGNILVIMAVSLERKLQNATNYFLRSLAITDMLLGILVMPV 117

  Fly   185 AGVNDLLGY-WIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVIT 248
            |.|..|.|| |......|..|:..||:.|||||::|||||:||||.|::|:.:.|..:...|.:.
Zfish   118 AMVTILYGYTWPLPRTLCPIWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRSNSLTKARVK 182

  Fly   249 IAAIWLLAAFVSF-VPISLGIHRPDQPLIFEDNGKKYPTCALDLTP-TYAVVSSCISFYFPCVVM 311
            |.|.|.::..:|. ||: ||:|         |:.|.:...:..||. .:.::.|.::|:.|.::|
Zfish   183 IIAAWTISVVISMPVPV-LGLH---------DHSKVFRNESCQLTDNNFVLIGSFVAFFVPLIIM 237

  Fly   312 IGIYCRLYCYAQKHVKSI--KAVTRP-----------GEVAEKQRY--KSIRRPKNQPKKFKVRN 361
            :..|.......|......  :.:.||           |.|:.::.:  .||.| :...:....|:
Zfish   238 VVTYFLTISALQSEATLCLDQLIVRPTWSSTIGLLPRGSVSSERLFSRSSICR-EGASRGSGRRS 301

  Fly   362 LHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFC-KTC----IGGQTFKILTWLGY 421
            :.:.|     ::.||:..:||:..:|:|.|.|||..|:.|..| ..|    :|| ...:..|:||
Zfish   302 MQSIS-----NEQKASKVLGVVFLLFVIMWCPFFVTNVMAVVCGSVCDEDLVGG-LMNVFVWVGY 360

  Fly   422 SNSAFNPIIYSIFNKEFRDAFKRILTMR 449
            .:||.||.||::|||.:|.||.|.:..|
Zfish   361 LSSAVNPFIYTLFNKTYRAAFARYMQCR 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	109/334 (33%)
		TM helix 1	130..156	CDD:320193	10/25 (40%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	18/29 (62%)
		TM helix 4	243..265	CDD:320193	7/22 (32%)
		TM helix 5	292..321	CDD:320193	6/29 (21%)
		TM helix 6	371..401	CDD:320193	11/29 (38%)
		TM helix 7	410..435	CDD:320193	10/24 (42%)
htr2ab	XP_009300470.1	7tm_GPCRs	62..381	CDD:475119	109/335 (33%)
		TM helix 1	64..88	CDD:410628	10/23 (43%)
		TM helix 2	97..119	CDD:410628	11/21 (52%)
		TM helix 3	136..158	CDD:410628	12/21 (57%)
		TM helix 4	181..197	CDD:410628	4/15 (27%)
		TM helix 5	219..242	CDD:410628	4/22 (18%)
		TM helix 6	312..334	CDD:410628	8/21 (38%)
		TM helix 7	349..374	CDD:410628	11/25 (44%)