DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and si:dkey-247m21.3

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_017208337.2	Gene:	si:dkey-247m21.3 / 559089	ZFINID:	ZDB-GENE-091204-249	Length:	390	Species:	Danio rerio

Alignment Length:	426	Identity:	136/426 - (31%)
Similarity:	193/426 - (45%)	Gaps:	90/426 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 MDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIADL 175
            :|.:|.:....::| |||:|     .:|.::..||:||.:|:..:|.|| :..|.|:.|||.|||
Zfish    12 VDEVVSKHTSRITL-SIVLV-----TIIIMTALGNLLVMVALCKDRQLRKKKTNFFIVSLAFADL 70

  Fly   176 FVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHI-KDPLRYGRW 239
            .||.:||..|.:....|.|.:|..||....:.||:.:|||||:||.|::|||..| ..||.|...
Zfish    71 LVALVVMPLAAIELTTGKWNYGETFCLVRTSLDVLLTTASILHLCCIALDRYYAICCQPLVYNNK 135

  Fly   240 VTRRVAVITIAAIWLLAAFVSFVPI-----SLGIHRPDQPLIFED---NGKKYPTCALDLTPTYA 296
            :|.....:.:...|::..|:||:||     ::||..     ..|.   |..:..||...:...||
Zfish   136 MTPVRVSLMLVGCWVIPFFISFLPIMQSWNTIGIES-----FIEQRKLNSSRNSTCVFMVNQPYA 195

  Fly   297 VVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRN 361
            :|.|.::||.|.|:|:..|.|:|..|..|.:.|.::.|.|. |....|     |.|.
Zfish   196 LVCSAVAFYVPLVLMVLAYQRIYVTAMGHARRIGSLHRAGS-APTSTY-----PNND-------- 246

  Fly   362 LHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAF 426
              .|.|....::.|||.|:.||||.|.:||.|||..|:...|....:..|.:....||||.||..
Zfish   247 --QHGSSRIKNETKAAKTLAVIMGCFCLCWAPFFVTNVVDPFINYSVPWQMWTAWLWLGYINSGL 309

  Fly   427 NPIIYSIFNKEFRDAFKRILTMRNPWCCAQD----VGNIHPR----------------------- 464
            ||.:|:..|:.||.||..||      ||..:    .|...|.
Zfish   310 NPFLYAFLNRAFRRAFLMIL------CCGDERYARQGGFSPSRQCSESVNGTSISLRLSFLQSRR 368

  Fly   465 ---NSDRFITDYAAKNVVVMNSGRSSAELE-QVSAI 496
               ||:||:                |.||| |.|||
Zfish   369 YSDNSNRFL----------------SCELESQESAI 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	51/138 (37%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	104/295 (35%)
si:dkey-247m21.3	XP_017208337.2	7tmA_5-HT4	23..325	CDD:320184	114/328 (35%)
		TM helix 1	24..50	CDD:320184	11/31 (35%)
		TM helix 2	58..84	CDD:320184	13/25 (52%)
		TM helix 3	96..126	CDD:320184	14/29 (48%)
		TM helix 4	139..162	CDD:320184	6/22 (27%)
		TM helix 5	191..220	CDD:320184	12/28 (43%)
		TM helix 6	254..284	CDD:320184	15/29 (52%)
		TM helix 7	293..318	CDD:320184	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010