Protein Alignment Dop1R1 and adrb1

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001122161.1
• Gene: adrb1 / 557194
• ZFINID: ZDB-GENE-081022-145
• Length: 390
• Species: Danio rerio
• Alignment Length: 433
• Identity: 142/433 - (32%)
• Similarity: 216/433 - (49%)
• Gaps: 79/433 - (18%)

  Fly    93 DGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTER 157
            ||....::.|:|   ..:.:|..|.|:       .:|.:||.:.:::|:.|.|||||.:||...:
Zfish     3 DGLPSVNYSNDS---KRATVDLNVSEQ-------WLVGMGILMGLIVFVIVVGNILVIVAIARNQ 57

  Fly   158 SLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAI 222
            .|:.:.|:|:.|||.|||.:..||:.|....::.|.|::|:.||:.|::.||:|.||||..||.|
Zfish    58 RLQTLTNVFIVSLACADLIMGLLVVPFGAALEVRGAWMYGSFFCEFWISLDVLCVTASIETLCVI 122

  Fly   223 SMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTC 287
            ::||||.|..|.||...:|:..|.:.:.|:|.::|.|||.||.:...:..:.....:|    |.|
Zfish   123 AIDRYIAIISPFRYQSLLTKARAKVVVCAVWAISALVSFPPILMHWSQDSEETSCYEN----PEC 183

  Fly   288 ALDLT-PTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPK 351
            ...:| ..||:.||.||||.|.:|||.:|.|:|..|::.:..|...        :.|:.:.....
Zfish   184 CDFVTNRAYAISSSIISFYIPLIVMIFVYARVYREAKQQLNKINKC--------EGRFYNNHGTN 240

  Fly   352 NQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKIL 416
            .:|.:.:...:      ..:.:.||..|:|:|||.|.:||:|||.||:...||...:..:.|..|
Zfish   241 CKPTRKRTTKI------LALKEQKALKTLGIIMGTFTLCWLPFFIVNVVRVFCAQVVDKELFVFL 299

  Fly   417 TWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVVM 481
            .||||.||||||||| ..:.:||.||||:|      ||        ||.:||.:
Zfish   300 NWLGYVNSAFNPIIY-CRSPDFRKAFKRLL------CC--------PRQADRRL----------- 338

  Fly   482 NSGRSSAELEQVSAIXPKCCLNLTGGG----------ATWLPC 514
                      .||:    |.|:...||          .||..|
Zfish   339 ----------HVSS----CDLSRCTGGFGNSMEQSMLGTWSDC 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	114/312 (37%)
		TM helix 1	130..156	CDD:320193	11/25 (44%)
		TM helix 2	163..189	CDD:320193	11/25 (44%)
		TM helix 3	201..231	CDD:320193	16/29 (55%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	16/29 (55%)
		TM helix 6	371..401	CDD:320193	15/29 (52%)
		TM helix 7	410..435	CDD:320193	15/24 (63%)
adrb1	NP_001122161.1	7tm_GPCRs	30..324	CDD:475119	114/312 (37%)
		TM helix 1	31..55	CDD:320624	11/23 (48%)
		TM helix 2	64..86	CDD:320624	11/21 (52%)
		TM helix 3	102..124	CDD:320624	11/21 (52%)
		TM helix 4	147..163	CDD:320624	6/15 (40%)
		TM helix 5	190..213	CDD:320624	12/22 (55%)
		TM helix 6	260..282	CDD:320624	12/21 (57%)
		TM helix 7	293..318	CDD:320624	15/25 (60%)