Protein Alignment Dop1R1 and drd4b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001012636.1
• Gene: drd4b / 503565
• ZFINID: ZDB-GENE-070508-3
• Length: 382
• Species: Danio rerio
• Alignment Length: 390
• Identity: 126/390 - (32%)
• Similarity: 179/390 - (45%)
• Gaps: 87/390 - (22%)

  Fly   126 VSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVM------TF 184
            |..:|.||.|.::|   :.||:||||::|.|::|:...|.|:.|||:|||.:|.||:      .|
Zfish    18 VPALVFGILLIIVI---ICGNVLVCLSVYKEKALKTTTNYFIVSLAVADLMLAVLVLPLFVYAEF 79

  Fly   185 AGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITI 249
            .|     |.|......||..:..|||..||||.||||||:||:|.:..||.|.|.......:|.:
Zfish    80 QG-----GVWSLNVSVCDGLMTMDVMLCTASIFNLCAISVDRFIAVSIPLNYNRKHVDYRQIILL 139

  Fly   250 AAIWLLAAFVSFVPISLGIH----RPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVV 310
            :|.||||..|: .|:..||:    |.......|||             .|.|.||..||:.||.:
Zfish   140 SATWLLALAVA-SPVIFGINNVPQRDPSECKLEDN-------------NYVVYSSVCSFFIPCPI 190

  Fly   311 MIGIYCRLY--------------------CYAQKHVKSIKAVTRPG-------EVAEKQRYKSIR 348
            |:.:|..::                    |.:.:|.....|:...|       .|.|:...:|..
Zfish   191 MLMLYFGMFHGLRKWEETRKAKLRNSIQACRSLQHAAVAAALPPLGALPASLPRVIERDLAQSSL 255

  Fly   349 RPKNQ--------PKKFKVRNLHT---------------HSSPYHVSDHKAAVTVGVIMGVFLIC 390
            ...:.        |.::|...:.|               ..:..:..:.||...:.|::||||.|
Zfish   256 EELDDFTQPVCPFPPEYKNSTIQTVAYSDIQYGQKTQRKKRAKINGRERKAMRVLPVVVGVFLFC 320

  Fly   391 WVPFFCVNITAAFCKTC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCC 454
            |.|||.|:.|.|.|::| |.......:|||||.|||.|||||::||.|||..|:..:    |.||
Zfish   321 WTPFFVVHTTRALCESCHISSDLMSTVTWLGYVNSALNPIIYTVFNTEFRKFFRGFV----PRCC 381

  Fly   455  454
            Zfish   382  381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	121/372 (33%)
		TM helix 1	130..156	CDD:320193	12/25 (48%)
		TM helix 2	163..189	CDD:320193	13/31 (42%)
		TM helix 3	201..231	CDD:320193	18/29 (62%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	10/48 (21%)
		TM helix 6	371..401	CDD:320193	13/29 (45%)
		TM helix 7	410..435	CDD:320193	13/24 (54%)
drd4b	NP_001012636.1	7tmA_D4_dopamine_R	20..373	CDD:320434	121/374 (32%)
		TM helix 1	20..45	CDD:320434	12/27 (44%)
		TM helix 2	52..78	CDD:320434	11/25 (44%)
		TM helix 3	91..121	CDD:320434	18/29 (62%)
		TM helix 4	133..156	CDD:320434	8/23 (35%)
		TM helix 5	172..201	CDD:320434	12/41 (29%)
		TM helix 6	301..331	CDD:320434	13/29 (45%)
		TM helix 7	341..366	CDD:320434	13/24 (54%)