Protein Alignment Dop1R1 and Dop1R2

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 161/538 - (29%)
• Similarity: 232/538 - (43%)
• Gaps: 124/538 - (23%)

  Fly    80 DIEIDIQLLTNGYDGTTLTSFYNESSWTNASEMDTIVG------EEPEP-----LSLVSIVVVGI 133
            :|..|:....||...:|.......:|.|:|:....:|.      ..|||     |..:....||:
  Fly    47 NISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGL 111

  Fly   134 --FLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLL-GYWI 195
              ||.:..|.:|.||.||.||:..||.|....|.|:.|||:||..|..:||.|:.:.::| ..|.
  Fly   112 LAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWF 176

  Fly   196 FGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVS 260
            ||..:||.|.:.||:.|||||||||.||:|||..|.||..|...:|.:.|...|||:|:.::.:|
  Fly   177 FGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAIS 241

  Fly   261 FVPISLGIHRPDQPLIF-----EDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYC 320
            |            |.|.     .|.......|.......|.|.||.||||.|.:||:..|||:|.
  Fly   242 F------------PAIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYR 294

  Fly   321 YAQKHVKSIKAVTRPGEVAEKQRYKSIR-----RPKNQPKKF---------------KVRNLHTH 365
            .|....:|:|..|:...:|..:...::|     ..::|..:.               .:.:.|:|
  Fly   295 AAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSH 359

  Fly   366 SSPYH-----------------------------------------------VSDHKAAVTVGVI 383
            |..:|                                               ..:.|||.|:|::
  Fly   360 SHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIV 424

  Fly   384 MGVFLICWVPFFCVNITAAFCKTCIGGQTF--KILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL 446
            ||||:|||:|||.||:.:.||..||..:..  .|:||||:.||..||:||:.::::||.||.|:|
  Fly   425 MGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL 489

  Fly   447 TMRNPWCCAQDV-GNIHPRNSDRFITDYAAKNVVVMNS-GRSSAE-------LEQVSAIXPKCCL 502
            .|    ||.:.: ....|....:.....||..|....| |..|..       ..|:|:     |.
  Fly   490 CM----CCPRKIRRKYQPTMRSKSQCHVAAAMVAASTSFGYHSVNQIDRTLMXRQLSS-----CS 545

  Fly   503 NLTGGGATWLPCGCGGLR 520
            ..:||.      .|||.|
  Fly   546 TCSGGS------NCGGSR 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	125/388 (32%)
		TM helix 1	130..156	CDD:320193	12/27 (44%)
		TM helix 2	163..189	CDD:320193	11/25 (44%)
		TM helix 3	201..231	CDD:320193	19/29 (66%)
		TM helix 4	243..265	CDD:320193	7/21 (33%)
		TM helix 5	292..321	CDD:320193	15/28 (54%)
		TM helix 6	371..401	CDD:320193	17/29 (59%)
		TM helix 7	410..435	CDD:320193	11/26 (42%)
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	120/374 (32%)
		TM helix 2	143..169	CDD:320195	11/25 (44%)
		TM helix 3	182..212	CDD:320195	19/29 (66%)
		TM helix 4	224..246	CDD:320195	8/33 (24%)
		TM helix 5	266..295	CDD:320195	15/28 (54%)
		TM helix 6	297..442	CDD:320195	27/144 (19%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)