DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R1 and OR5T3

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001004747.2	Gene:	OR5T3 / 390154	HGNCID:	15297	Length:	322	Species:	Homo sapiens

Alignment Length:	367	Identity:	76/367 - (20%)
Similarity:	122/367 - (33%)	Gaps:	135/367 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 IFLSVLIF----LSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLV-----MTFAGVN 188
            :||.:|.|    .::.||:.:.:.:..:..|......||:.|:..|...:::|     :.|...|
Human    37 VFLFLLFFAIYLFTLIGNLGLVVLVIEDSWLHNPMYYFLSVLSFLDACYSTVVTPKMLVNFLAKN 101

  Fly   189 DLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAV------- 246
            ..:.:  .|   |.|.:...|...|.....|.|::.|.|:.|.:||.|...::.||.|
Human   102 KSISF--IG---CATQMLLFVTFGTTECFLLAAMAYDHYVAIYNPLLYSVSMSPRVYVPLITASY 161

  Fly   247 ---ITIAAIWLLAAF-VSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSC------ 301
               |..|.|.::|.| :||.               ..|..::..|  |:.|..|:  ||
Human   162 VAGILHATIHIVATFSLSFC---------------GSNEIRHVFC--DMPPLLAI--SCSDTHTN 207

  Fly   302 --ISFYFP--------CVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKK 356
              :.|||.        .:|:|.....|....:.|                       ..|.:.|.
Human   208 QLLLFYFVGSIEIVTILIVLISCDFILLSILKMH-----------------------SAKGRQKA 249

  Fly   357 FKVRNLH-THSSPYH--------------VSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKT 406
            |.....| |..:.||              .|||      .:|:.:|....:|
Human   250 FSTCGSHLTGVTIYHGTILVSYMRPSSSYASDH------DIIVSIFYTIVIP------------- 295

  Fly   407 CIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTM 448
                              ..||||||:.|||.:.|.|::|.:
Human   296 ------------------KLNPIIYSLRNKEVKKAVKKMLKL 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	37/151 (25%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	63/332 (19%)
OR5T3	NP_001004747.2	7tm_GPCRs	50..315	CDD:421689	70/348 (20%)
		TM helix 2	71..97	CDD:410628	5/25 (20%)
		TM helix 3	109..139	CDD:410628	8/29 (28%)
		TM helix 4	152..173	CDD:410628	5/20 (25%)
		TM helix 5	207..237	CDD:410628	6/29 (21%)
		TM helix 6	244..274	CDD:410628	7/29 (24%)
		TM helix 7	281..306	CDD:410628	11/61 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100