Protein Alignment Dop1R1 and drd2b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_922918.1
• Gene: drd2b / 378719
• ZFINID: ZDB-GENE-030910-2
• Length: 452
• Species: Danio rerio
• Alignment Length: 464
• Identity: 133/464 - (28%)
• Similarity: 207/464 - (44%)
• Gaps: 131/464 - (28%)

  Fly    97 LTSF-YNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLR 160
            ||.: ||::.:.|.:......|.|.:.    ......:.|::|||:.|.||:|||:|:..|::|:
Zfish     4 LTEYPYNDTYYDNGTGALNCTGCEAKH----QYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQ 64

  Fly   161 RIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMD 225
            ...|..:.|||:|||.||:|||.:....:::|.|.|....||.:|..|||..|||||||||||:|
Zfish    65 TTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSKIHCDIFVTLDVMMCTASILNLCAISID 129

  Fly   226 RYIHIKDPLRYG-RWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNG---KKYPT 286
            ||..:..|:.|. |:.::|...:.|:.:|:|:..:|.            ||:|..|.   :....
Zfish   130 RYTAVAMPMLYNTRYSSKRRVTVMISVVWVLSFAISC------------PLLFGLNNTATRDGSV 182

  Fly   287 CALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSI------------------KAVT 333
            |.: ..|.:.|.||.:|||.|.::.:.:|.::|...:|..|.:                  :..|
Zfish   183 CEI-ANPAFVVYSSIMSFYVPFIITLLVYVQIYVVLRKRRKRVNTKRSCQKTDADAQPPLKEKCT 246

  Fly   334 RPGEV--------------AEKQRYKSIRRPKNQ--------------PKKFKVRN------LHT 364
            .|.:|              |:.::.:.|:...:|              |:|.|:.:      |.|
Zfish   247 HPEDVKLCTVIIKTNGGVPAKNKKAQLIKEVLHQGGDVGMEMVAGTSPPEKKKLASSLVVDLLAT 311

  Fly   365 -----HSSPYH------------------------------------------------VSDH-- 374
                 |.||.|                                                :|.|
Zfish   312 PPSPNHGSPSHAEYQSNGDEKNGHAKDVQSPKETKPVETQALPNGKTRTTVTKTMSKRKMSQHKE 376

  Fly   375 -KAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGG-QTFKILTWLGYSNSAFNPIIYSIFNKE 437
             ||...:.:::|||:|||:|||..:|....|.:|:.. :.:...|||||.|||.|||||:.||.|
Zfish   377 KKATQMLAIVLGVFIICWLPFFITHILKTHCTSCVVPLEMYNAFTWLGYVNSAVNPIIYTTFNVE 441

  Fly   438 FRDAFKRIL 446
            ||.||.:||
Zfish   442 FRKAFIKIL 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	122/424 (29%)
		TM helix 1	130..156	CDD:320193	11/25 (44%)
		TM helix 2	163..189	CDD:320193	12/25 (48%)
		TM helix 3	201..231	CDD:320193	20/29 (69%)
		TM helix 4	243..265	CDD:320193	5/21 (24%)
		TM helix 5	292..321	CDD:320193	10/28 (36%)
		TM helix 6	371..401	CDD:320193	14/32 (44%)
		TM helix 7	410..435	CDD:320193	13/25 (52%)
drd2b	NP_922918.1	7tm_GPCRs	33..446	CDD:475119	122/425 (29%)
		TM helix 1	35..59	CDD:410628	11/23 (48%)
		TM helix 2	68..90	CDD:410628	12/21 (57%)
		TM helix 3	106..128	CDD:410628	15/21 (71%)
		TM helix 4	152..168	CDD:410628	4/27 (15%)
		TM helix 5	188..211	CDD:410628	8/22 (36%)
		TM helix 6	380..402	CDD:410628	9/21 (43%)
		TM helix 7	414..439	CDD:410628	13/24 (54%)