Protein Alignment Dop1R1 and HTR7

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_062873.1
• Gene: HTR7 / 3363
• HGNCID: 5302
• Length: 479
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 115/341 - (33%)
• Similarity: 179/341 - (52%)
• Gaps: 40/341 - (11%)

  Fly   126 VSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDL 190
            |..||:|..|:::..|::|||.||.:::...:.||:..|..:.|||:|||.||..||.|..|.||
Human    79 VEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDL 143

  Fly   191 L-GYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWL 254
            : |.||||..||:.::|.||||.||||:.||.||:|||:.|..||.|......:.....|.::||
Human   144 IGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWL 208

  Fly   255 LAAFVSFVPI---SLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYC 316
            |:|.::..|:   :..::.....||.:|.|             |.:.|:.::||.|..||:.:|.
Human   209 LSASITLPPLFGWAQNVNDDKVCLISQDFG-------------YTIYSTAVAFYIPMSVMLFMYY 260

  Fly   317 RLYCYAQKHVKSIK----------AVTRPGEVAEKQRYKSIRRPKNQPK--KFKVRNLHTHSSPY 369
            ::|..|:|.....|          :|.....:.:.|  |.:....|..:  |.:.:|:....
Human   261 QIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQ--KEVEECANLSRLLKHERKNISIFK--- 320

  Fly   370 HVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAF-CKT---CIGGQTFKILTWLGYSNSAFNPII 430
              .:.|||.|:|:|:|.|.:||:|||.::....| |.|   ||.....:...||||:||..||.|
Human   321 --REQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFI 383

  Fly   431 YSIFNKEFRDAFKRIL 446
            |:.||::.|..::.:|
Human   384 YAFFNRDLRTTYRSLL 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	112/331 (34%)
		TM helix 1	130..156	CDD:320193	9/25 (36%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	17/29 (59%)
		TM helix 4	243..265	CDD:320193	6/24 (25%)
		TM helix 5	292..321	CDD:320193	9/28 (32%)
		TM helix 6	371..401	CDD:320193	13/29 (45%)
		TM helix 7	410..435	CDD:320193	10/24 (42%)
HTR7	NP_062873.1	7tmA_5-HT7	97..395	CDD:320452	108/317 (34%)
		TM helix 2	116..142	CDD:320452	13/25 (52%)
		TM helix 3	155..185	CDD:320452	17/29 (59%)
		TM helix 4	197..219	CDD:320452	6/21 (29%)
		TM helix 5	236..265	CDD:320452	11/41 (27%)
		TM helix 6	320..350	CDD:320452	13/34 (38%)
		TM helix 7	363..388	CDD:320452	10/24 (42%)