Protein Alignment Dop1R1 and HTR6

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_000862.1
• Gene: HTR6 / 3362
• HGNCID: 5301
• Length: 440
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 147/442 - (33%)
• Similarity: 209/442 - (47%)
• Gaps: 57/442 - (12%)

  Fly   131 VGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWI 195
            |...|.|:|.|:.|.|.|:...|.|:.:||...|.||.||..:||.|..:||..|.:|.|.|.|:
Human    29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWV 93

  Fly   196 FGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVS 260
            .....|..|.||||||.:|||||||.||:|||:.|..||||...:|...|:..:...|.|||..|
Human    94 LARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAS 158

  Fly   261 FVPISLGIH-----RPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYC 320
            |:|:.||.|     ||..|      |:    |.|..:..:.:|:|.::|:.|...:...|||:..
Human   159 FLPLLLGWHELGHARPPVP------GQ----CRLLASLPFVLVASGLTFFLPSGAICFTYCRILL 213

  Fly   321 YAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMG 385
            .|:|....:.::|........:..:..|.|:...:....|.|.|..|...:   ||::|:|:::|
Human   214 AARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKAL---KASLTLGILLG 275

  Fly   386 VFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRN 450
            :|.:.|:|||..||..|.| .||....|.:||||||.||..|||||.:|.::|:.|..|.|..
Human   276 MFFVTWLPFFVANIVQAVC-DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC-- 337

  Fly   451 PWCCAQDVGNIHPRNSDRFITDYAAKNVVVMNSG-RSSAELEQV--SAIXPKCCLNLTGGGATWL 512
            |.|         ||...   ...|:.::...:|| |....|:||  ..:.|....:...|..
Human   338 PRC---------PRERQ---ASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSG--- 387

  Fly   513 PCGCGGLRV--------DDDDDGALTTRYVPXDSVTAATATIVETVEAAQME 556
              |..|||:        :...|..|.||        ||.|.....::.|:.|
Human   388 --GSSGLRLTAQLLLPGEATQDPPLPTR--------AAAAVNFFNIDPAEPE 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	118/315 (37%)
		TM helix 1	130..156	CDD:320193	9/24 (38%)
		TM helix 2	163..189	CDD:320193	11/25 (44%)
		TM helix 3	201..231	CDD:320193	20/29 (69%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	7/28 (25%)
		TM helix 6	371..401	CDD:320193	12/29 (41%)
		TM helix 7	410..435	CDD:320193	14/24 (58%)
HTR6	NP_000862.1	7tmA_5-HT6	27..331	CDD:320182	118/315 (37%)
		TM helix 1	28..54	CDD:320182	9/24 (38%)
		TM helix 2	61..87	CDD:320182	11/25 (44%)
		TM helix 3	99..129	CDD:320182	20/29 (69%)
		TM helix 4	141..164	CDD:320182	8/22 (36%)
		TM helix 5	185..214	CDD:320182	7/28 (25%)
		TM helix 6	261..291	CDD:320182	12/32 (38%)
		TM helix 7	299..324	CDD:320182	14/24 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..392		10/50 (20%)