Protein Alignment Dop1R1 and HTR5A

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_076917.1
• Gene: HTR5A / 3361
• HGNCID: 5300
• Length: 357
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 122/373 - (32%)
• Similarity: 192/373 - (51%)
• Gaps: 41/373 - (10%)

  Fly    97 LTSFYNESSWTNASEMDT--IVGEE----PEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYT 155
            ||||    |.:..|.::|  .:|::    ..||..|..|::...|..|:..:.|.|:||...|..
Human     7 LTSF----SLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILR 67

  Fly   156 ERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLG-YWIFGAQFCDTWVAFDVMCSTASILNL 219
            .|:..|:.:..:||:|::|:.||:|||..:.|::|.| .|..|.:.|..|:|.||:|.||||.|:
Human    68 VRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNV 132

  Fly   220 CAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKY 284
            .||::|||..|...:.|.....:.|:.:.||..|.|:|.:|..|:..|.            |:.|
Human   133 TAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGW------------GETY 185

  Fly   285 ----PTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIK--AVTRPGEVAEKQR 343
                ..|.:...|:|||.|:..:||.|..|::.:|.::|..|:..|.|.|  :|:...|..|
Human   186 SEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVE--- 247

  Fly   344 YKSIRRPKNQPKK-FKVRNLHTHSSP-----YHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAA 402
               ::....||:. |.||:......|     ....:.:||:.||:::|||::||:|||...:.:.
Human   248 ---VKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISP 309

  Fly   403 FCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRN 450
            .|...|......|..|||||||.|||:||:.|||.:..|||...:.::
Human   310 LCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	107/324 (33%)
		TM helix 1	130..156	CDD:320193	7/25 (28%)
		TM helix 2	163..189	CDD:320193	10/25 (40%)
		TM helix 3	201..231	CDD:320193	16/29 (55%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	11/28 (39%)
		TM helix 6	371..401	CDD:320193	12/29 (41%)
		TM helix 7	410..435	CDD:320193	13/24 (54%)
HTR5A	NP_076917.1	7tmA_5-HT5	41..349	CDD:320451	108/325 (33%)
		TM helix 1	42..68	CDD:320451	7/25 (28%)
		TM helix 2	75..101	CDD:320451	10/25 (40%)
		TM helix 3	114..144	CDD:320451	16/29 (55%)
		TM helix 4	156..177	CDD:320451	7/20 (35%)
		TM helix 5	197..226	CDD:320451	11/28 (39%)
		TM helix 6	278..308	CDD:320451	12/29 (41%)
		TM helix 7	317..342	CDD:320451	13/24 (54%)