Protein Alignment Dop1R1 and HTR4

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001035263.1
• Gene: HTR4 / 3360
• HGNCID: 5299
• Length: 428
• Species: Homo sapiens
• Alignment Length: 382
• Identity: 131/382 - (34%)
• Similarity: 192/382 - (50%)
• Gaps: 39/382 - (10%)

  Fly   111 EMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRI-GNLFLASLAIAD 174
            ::|..|..| |....|..||:..|||.:|.:::.||:||.:|:..:|.||:| .|.|:.|||.||
Human     3 KLDANVSSE-EGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFAD 66

  Fly   175 LFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHI-KDPLRYGR 238
            |.|:.|||.|..:..:...||:|..||....:.||:.:||||.:||.||:|||..| ..||.|..
Human    67 LLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRN 131

  Fly   239 WVTRRVAVITIAAIWLLAAFVSFVPI-----SLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVV 298
            .:|.....:.:...|::..|:||:||     ::||....:...|..|... ..|...:...||:.
Human   132 KMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNS-TYCVFMVNKPYAIT 195

  Fly   299 SSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLH 363
            .|.::||.|.::|:..|.|:|..|::|...|:.:.|.|..:|.       ||::..:
Human   196 CSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSES-------RPQSADQ-------- 245

  Fly   364 THSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNP 428
             ||:....::.|||.|:.:|||.|.:||.|||..||...|....:.||.:....||||.||..||
Human   246 -HSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNP 309

  Fly   429 IIYSIFNKEFRDAFKRIL-----TMRNPWCCAQDV--------GNIHPRNSDRFITD 472
            .:|:..||.||.||..||     ..|.|....|.|        |:.|...:| |:.|
Human   310 FLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRTD-FLFD 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	112/318 (35%)
		TM helix 1	130..156	CDD:320193	10/25 (40%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	15/30 (50%)
		TM helix 4	243..265	CDD:320193	6/26 (23%)
		TM helix 5	292..321	CDD:320193	10/28 (36%)
		TM helix 6	371..401	CDD:320193	15/29 (52%)
		TM helix 7	410..435	CDD:320193	11/24 (46%)
HTR4	NP_001035263.1	7tmA_5-HT4	20..323	CDD:320184	113/319 (35%)
		TM helix 1	21..47	CDD:320184	10/25 (40%)
		TM helix 2	55..81	CDD:320184	13/25 (52%)
		TM helix 3	93..123	CDD:320184	14/29 (48%)
		TM helix 4	136..159	CDD:320184	6/22 (27%)
		TM helix 5	189..218	CDD:320184	10/28 (36%)
		TM helix 6	252..282	CDD:320184	15/29 (52%)
		TM helix 7	291..316	CDD:320184	11/24 (46%)