DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and HTR4

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001035263.1	Gene:	HTR4 / 3360	HGNCID:	5299	Length:	428	Species:	Homo sapiens

Alignment Length:	382	Identity:	131/382 - (34%)
Similarity:	192/382 - (50%)	Gaps:	39/382 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 EMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRI-GNLFLASLAIAD 174
            ::|..|..| |....|..||:..|||.:|.:::.||:||.:|:..:|.||:| .|.|:.|||.||
Human     3 KLDANVSSE-EGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFAD 66

  Fly   175 LFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHI-KDPLRYGR 238
            |.|:.|||.|..:..:...||:|..||....:.||:.:||||.:||.||:|||..| ..||.|..
Human    67 LLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRN 131

  Fly   239 WVTRRVAVITIAAIWLLAAFVSFVPI-----SLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVV 298
            .:|.....:.:...|::..|:||:||     ::||....:...|..|... ..|...:...||:.
Human   132 KMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNS-TYCVFMVNKPYAIT 195

  Fly   299 SSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLH 363
            .|.::||.|.::|:..|.|:|..|::|...|:.:.|.|..:|.       ||::..:
Human   196 CSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSES-------RPQSADQ-------- 245

  Fly   364 THSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNP 428
             ||:....::.|||.|:.:|||.|.:||.|||..||...|....:.||.:....||||.||..||
Human   246 -HSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNP 309

  Fly   429 IIYSIFNKEFRDAFKRIL-----TMRNPWCCAQDV--------GNIHPRNSDRFITD 472
            .:|:..||.||.||..||     ..|.|....|.|        |:.|...:| |:.|
Human   310 FLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRTD-FLFD 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	55/138 (40%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	102/292 (35%)
HTR4	NP_001035263.1	7tm_1	36..312	CDD:278431	102/292 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010